Photo by Bill Dillard

Southeast Missouri Hotels with parking

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Check availability on Southeast Missouri Hotels with parking

Our top choices for Southeast Missouri hotels with parking

Indoor pool, outdoor pool
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1003)
"Clean room, great location and friendly staff"
United States
Mark
The price is RM368
RM423 total
includes taxes & fees
22 Dec - 23 Dec
Drury Inn & Suites Sikeston, MO
Premium bedding, down duvets, pillow-top beds, in-room safe
The Farmstead Hotel

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.8 out of 10, Excellent, (463)
"Nice place "
United States
Debbie
The price is RM350
RM398 total
includes taxes & fees
18 Dec - 19 Dec
The Farmstead Hotel
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1004)
"Great place and staff, very accommodating!"
United States
Megan
The price is RM368
RM415 total
includes taxes & fees
23 Dec - 24 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby lounge
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (855)
"Very clean, great check in"
United States
Teresa
The price is RM426
RM481 total
includes taxes & fees
16 Jan - 17 Jan 2026
Fairfield Inn & Suites by Marriott Poplar Bluff
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1001)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is RM389
RM439 total
includes taxes & fees
22 Dec - 23 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Breakfast, lunch, dinner served; Italian cuisine
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (702)
"Amazing place"
United States
Mladen
The price is RM414
RM468 total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Poplar Bluff by IHG
Lobby
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (964)
"Nice room helpful staff. "
United States
Deborah
The price is RM385
RM435 total
includes taxes & fees
20 Dec - 21 Dec
Drury Inn & Suites Poplar Bluff
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1003)
"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "
United States
joseph
The price is RM293
RM333 total
includes taxes & fees
21 Dec - 22 Dec
Best Western Plus Sikeston
Front of property
Echo Bluff State Park

Echo Bluff State Park

Echo Bluff State Park
2.5 star property
Eminence
9.6 out of 10, Exceptional, (217)
"The cabin was beautiful, comfy, & private! The park was FANTASTIC for hiking & scenery! We hope to return and maybe bring family or friends. The staff were all friendly too! :)"
United States
Joanne
The price is RM651
RM688 total
includes taxes & fees
17 Dec - 18 Dec
Echo Bluff State Park
Reception
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is RM413
RM462 total
includes taxes & fees
10 Jan - 11 Jan 2026
Hampton Inn Poplar Bluff
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southeast Missouri Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Beds were great. Very clean all around. Very nice breakfast with glutten free bread for my wife. "
Jim 1-night trip
Posted 8 days ago
Drury Plaza Hotel Cape Girardeau Conference Center

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