Photo by Jessica Richter

Southeast Missouri Vacation Rentals

    Plan, book, stay with confidence
    bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    today icon
    Change your mind
    Book hotels with free cancellation

Vacation Rentals in Southeast Missouri

Exterior
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
3.5 star property
9.4 out of 10, Exceptional, (126)
"When we walked in the lodge it was spotless. Very homey and clean. The staff was so kind. We will definitely be back."
The price is RM 673
per night
9 Jun - 10 Jun
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
Don't see what you're looking for?
See all available properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other types of properties in Southeast Missouri you may be interested in

Lobby
Pear Tree Inn Cape Girardeau West
2.5 star property
9.0 out of 10, Wonderful, (1000)
"We never heard another person. Staff was wonderful."
The price is RM 308
per night
2 Jun - 3 Jun
Pear Tree Inn Cape Girardeau West
BBQ/picnic Area
Auburn Place Hotel And Suites
2.5 star property
8.8 out of 10, Excellent, (1001)
"Staff and premises were top knotch.i had family come vist and swim for a bit and they were welcoming to my guest.The manager and staff complimented eachother.very good work= physicaly and socially..room was clean smelled good nothing out of place.. I DIDNT WANT TO LEAVE!! LOL THANK YOU FOLKS FOR A WONDERFUL VACATION NIGHT STAY!! THE BEST "
The price is RM 317
per night
29 May - 30 May
Auburn Place Hotel And Suites
Blackout curtains, free WiFi, bed sheets
Motel 6 Poplar Bluff, MO
2.0 star property
8.0 out of 10, Very good, (1000)
"This hotel is definitely not as bad as everyone says. Definitely the best food selection as for vending machines. The only bad thing would have to be the smell of the rooms. It’s an odd smell but not like dead animal odd smell"
The price is RM 370
per night
27 May - 28 May
Motel 6 Poplar Bluff, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Search for holiday rentals in Southeast Missouri on Expedia.co.uk! You can easily find your home rentals, villas, holiday apartments in Southeast Missouri using one of the methods below:

  • View our selection of featured holiday rentals in Southeast Missouri
  • Use the map to find apartments and other holiday homes in the Southeast Missouri neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Southeast Missouri while they last

Look no further and take a look at our great range of rental properties in Southeast Missouri!

Recent reviews of Southeast Missouri properties
Expedia verified reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

5/5 Excellent
"Very nice and clean hotel"
A verified traveller stayed at Drury Inn & Suites Cape Girardeau
Posted 1 day ago
Drury Inn & Suites Cape Girardeau