Southeast Missouri hotels from RM260
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Our top choices for Southeast Missouri hotels
1. Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.6 out of 10, Exceptional, (1,007 reviews)
"Nice hotel with evening dinner and buffet breakfast."
Sally
The price is RM455
RM523 total
includes taxes & fees
26 Jul - 27 Jul
2. Shepherd Mountain Inn
Shepherd Mountain InnIronton
9.2 out of 10, Wonderful, (323 reviews)
"This was the perfect little place for my husband and I to stay for our little vacation. Very quiet, close to many state parks and beautiful scenery. The staff was friendly, the room was clean and organized, and the breakfast was very good. We will definitely stay there again next time we are in the area."
Katie
The price is RM502
RM548 total
includes taxes & fees
1 Aug - 2 Aug
3. Madison Inn Lodge
Madison Inn LodgeFredericktown
7.6 out of 10, Good, (305 reviews)
"Rooms were clean! Beds were comfortable, and the staff were very accommodating."
Ashley
The price is RM358
RM392 total
includes taxes & fees
25 Jul - 26 Jul
4. Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (940 reviews)
"I absolutely love staying at Fairfield, that's my go to place. The staff is extremely nice, and amazing, the rooms are clean the bed us comfortable."
Tequilla
The price is RM414
RM468 total
includes taxes & fees
9 Aug - 10 Aug
5. Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (606 reviews)
"Breakfast was good nice beds very nice stay"
scott
The price is RM363
RM416 total
includes taxes & fees
16 Aug - 17 Aug
6. Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,008 reviews)
"Room is was very comfortable I food was good pool and hot tub was super clean and fun also good food and nice service even the guests are very friendly."
Jahniya
The price is RM410
RM462 total
includes taxes & fees
2 Aug - 3 Aug
7. Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (903 reviews)
"Great overnight restful stay"
Philip
The price is RM383
RM429 total
includes taxes & fees
9 Aug - 10 Aug
8. Arcadia Academy
Arcadia AcademyArcadia
9.6 out of 10, Exceptional, (14 reviews)
"We enjoyed ourselves we've been to plenty of places but we had a great excellent time people the room the food and it was great we will be backĀ”!!!"
John
9. Fort Davidson Hotel
Fort Davidson HotelIronton
9.2 out of 10, Wonderful, (184 reviews)
"We really enjoyed our stay. It was located near everything we wanted to do in that area. It is not a new location, but it was a good value. We would stay there again."
John
The price is RM492
RM537 total
includes taxes & fees
16 Aug - 17 Aug
10. Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (652 reviews)
"It was a beautiful room and definitely wanted to stay longer"
Ronny
The price is RM501
RM546 total
includes taxes & fees
3 Aug - 4 Aug
11. Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,003 reviews)
"This hotel was so clean and comfy! The breakfast was awesome too!"
Jamie
The price is RM328
RM346 total
includes taxes & fees
2 Aug - 3 Aug
12. Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (209 reviews)
"The staff at breakfast was wonderful!"
Heather
The price is RM379
RM428 total
includes taxes & fees
2 Aug - 3 Aug
13. Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (593 reviews)
"Staff were great at Check in, room was clean, breakfast was good."
Brandi
The price is RM433
RM491 total
includes taxes & fees
13 Aug - 14 Aug
14. Black River Motel and Restaurant
Black River Motel and RestaurantLesterville
8.6 out of 10, Excellent, (43 reviews)
"Staff was very helpful and friendly"
Douglas
The price is RM528
RM559 total
includes taxes & fees
26 Jul - 27 Jul
15. Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHGSikeston
8.6 out of 10, Excellent, (483 reviews)
"Nice!"
theresa
The price is RM375
RM424 total
includes taxes & fees
26 Jul - 27 Jul
16. Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (152 reviews)
"This is a great place to stay for families. The lobby is filled with board games, books, has a pool table, corn hole, and lots of different sitting areas. The hotel was clean and the staff was very nice. We came up for a ball tournament and will stay again!"
Rebecca
The price is RM366
RM417 total
includes taxes & fees
2 Aug - 3 Aug
17. EC Reed's Mercantile and Hotel
EC Reed's Mercantile and HotelMarble Hill
9.6 out of 10, Exceptional, (102 reviews)
"Nice place to stay"
JANEEN
The price is RM421
RM459 total
includes taxes & fees
22 Jul - 23 Jul
18. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (805 reviews)
"Hotel was very clean and staff was very helpful. Would definitely stay there again!"
George
The price is RM379
RM411 total
includes taxes & fees
2 Aug - 3 Aug
19. Super 8 by Wyndham Farmington
Super 8 by Wyndham FarmingtonFarmington
8.0 out of 10, Very good, (662 reviews)
"Will stay here when I return"
Sarah
The price is RM254
RM277 total
includes taxes & fees
17 Aug - 18 Aug
20. Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
8.0 out of 10, Very good, (1,005 reviews)
"Great place"
Kellie
The price is RM239
RM260 total
includes taxes & fees
18 Aug - 19 Aug
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (86 reviews)
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Stay near popular Southeast Missouri attractions
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouriāwineries, a scenic riverfront and sights from Sam A. Baker State Park to Walnut Hollow Lake.
Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
10/10 Excellent
More cheap stays in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is RM239 per night from 18 Aug to 19 Aug
RM239
RM260 total
18 Aug - 19 Aug
includes taxes & fees
8/10 Very good! (1,005 reviews)
4 Star Hotels
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