
Southeast Missouri hotels from RM242
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Southeast Missouri
Family friendly
Check prices for these dates
Our top choices for Southeast Missouri hotels

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,011 reviews)
The price is RM360
RM380 total
includes taxes & fees
25 Jun - 26 Jun

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (195 reviews)
The price is RM372
RM419 total
includes taxes & fees
25 Jun - 26 Jun

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,002 reviews)
The price is RM401
RM453 total
includes taxes & fees
21 Jun - 22 Jun

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (1,006 reviews)
The price is RM441
RM498 total
includes taxes & fees
7 Jun - 8 Jun

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.6 out of 10, Excellent, (557 reviews)
The price is RM381
RM433 total
includes taxes & fees
7 Jun - 8 Jun

Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (132 reviews)
The price is RM359
RM408 total
includes taxes & fees
5 Jul - 6 Jul

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (75 reviews)
The price is RM436
RM641 total
includes taxes & fees
28 Jun - 29 Jun

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (911 reviews)
The price is RM457
RM517 total
includes taxes & fees
20 Jun - 21 Jun

The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (589 reviews)
The price is RM529
RM597 total
includes taxes & fees
17 Jun - 18 Jun

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHGFestus
9.4 out of 10, Exceptional, (730 reviews)
The price is RM485
RM555 total
includes taxes & fees
14 Jun - 15 Jun

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.6 out of 10, Exceptional, (1,006 reviews)
The price is RM445
RM512 total
includes taxes & fees
21 Jun - 22 Jun

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (84 reviews)
The price is RM440
RM498 total
includes taxes & fees
25 Jun - 26 Jun

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (862 reviews)
The price is RM411
RM460 total
includes taxes & fees
1 Jul - 2 Jul

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis SouthFestus
8.0 out of 10, Very good, (992 reviews)
The price is RM338
RM386 total
includes taxes & fees
17 Jun - 18 Jun

Super 8 by Wyndham Perryville
Super 8 by Wyndham PerryvillePerryville
8.4 out of 10, Very good, (1,001 reviews)
The price is RM283
RM324 total
includes taxes & fees
14 Jun - 15 Jun

Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (629 reviews)
The price is RM440
RM479 total
includes taxes & fees
4 Jul - 5 Jul

Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
8.0 out of 10, Very good, (1,001 reviews)
The price is RM238
RM259 total
includes taxes & fees
21 Jun - 22 Jun

Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau DowntownCape Girardeau
9.6 out of 10, Exceptional, (514 reviews)
The price is RM502
RM569 total
includes taxes & fees
28 Jun - 29 Jun

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (777 reviews)
The price is RM370
RM401 total
includes taxes & fees
17 Jun - 18 Jun

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (592 reviews)
The price is RM405
RM464 total
includes taxes & fees
9 Jun - 10 Jun
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (75 reviews)
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Southeast Missouri attractions
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Clearwater Lake.

Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Hayti Caruthersville
10/10 Excellent
More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is RM238 per night from 21 Jun to 22 Jun
RM238
RM259 total
21 Jun - 22 Jun
includes taxes & fees
8/10 Very Good! (1,001 reviews)

4 Star Hotels
2 properties
Explore a world of travel with Expedia
- Belleview Hotels
- Bernie Hotels
- Black Hotels
- Bloomsdale Hotels
- Bunker Hotels
- Caravan Parks in Butler County
- Hotels with smoking rooms in Cape Girardeau
- Caravan Parks in Carter County
- De Soto Hotels
- Desloge Hotels
- Budget Hotels in Cape Girardeau County
- Pet friendly Hotels in Cape Girardeau County
- Lesterville Hotels
- Park Hills Hotels
- Qulin Hotels
- Caravan Parks in Ripley County
- Independent Hotels in Sikeston
- Sikeston Hotels
- B&B in Ste. Genevieve County
- Ste Genevieve Hotels
- Lodges in Washington County
- Flights to Bernie
- Flights from New Offenburg
- Flights from Qulin
- Flights from Tiff
- Flights from Accra (ACC) to Cape Girardeau (CGI)
- Flights from Alpine (ALE) to Cape Girardeau (CGI)
- Flights from Dallas (DFW) to Poplar Bluff (POF)
- Flights from Doha (DOH) to Cape Girardeau (CGI)
- Flights from Hagerstown (HGR) to Cape Girardeau (CGI)
- Flights from Wilmington (ILM) to Cape Girardeau (CGI)
- Flights from Kuala Lumpur (KUL) to Cape Girardeau (CGI)
- Flights from Columbus (LCK) to Cape Girardeau (CGI)
- Flights from Kansas City (MCI) to Cape Girardeau (CGI)
- Flights from Port of Spain (POS) to Cape Girardeau (CGI)
- Flights from San Antonio (SAT) to Poplar Bluff (POF)
- Flights from Valdosta (VLD) to Cape Girardeau (CGI)






































































































