Southeast Missouri hotels from RM250
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11 Sept - 13 SeptOur top choices for Southeast Missouri hotels
1. Madison Inn Lodge
Madison Inn LodgeFredericktown
Bawan
RM354
RM386 total
includes taxes & fees
5 Oct - 6 Oct
2. Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
Victor K
RM332
RM351 total
includes taxes & fees
21 Sept - 22 Sept
3. Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
Arsenia
RM409
RM462 total
includes taxes & fees
4 Oct - 5 Oct
4. Shepherd Mountain Inn
Shepherd Mountain InnIronton
Katie
RM498
RM544 total
includes taxes & fees
5 Oct - 6 Oct
5. Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
Sheila
RM378
RM423 total
includes taxes & fees
4 Oct - 5 Oct
6. Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
Sandra
RM404
RM456 total
includes taxes & fees
4 Oct - 5 Oct
7. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
crystal
RM375
RM405 total
includes taxes & fees
16 Sept - 17 Sept
8. Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHGSikeston
Melissa
RM425
RM481 total
includes taxes & fees
13 Sept - 14 Sept
9. Fort Davidson Hotel
Fort Davidson HotelIronton
richard
RM485
RM530 total
includes taxes & fees
4 Oct - 5 Oct
10. Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
Allen
RM409
RM463 total
includes taxes & fees
13 Sept - 14 Sept
11. Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
Susan
RM426
RM464 total
includes taxes & fees
10 Sept - 11 Sept
12. Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
Scott Andrew
RM380
RM437 total
includes taxes & fees
14 Sept - 15 Sept
13. EC Reed's Mercantile and Hotel
EC Reed's Mercantile and HotelMarble Hill
JANEEN
RM340
RM370 total
includes taxes & fees
6 Sept - 7 Sept
14. Hampton Inn Sikeston
Hampton Inn SikestonSikeston
Jeffrey
RM424
RM480 total
includes taxes & fees
13 Sept - 14 Sept
15. Super 8 by Wyndham Farmington
Super 8 by Wyndham FarmingtonFarmington
David
RM241
RM262 total
includes taxes & fees
13 Sept - 14 Sept
16. Holiday Inn Poplar Bluff by IHG
Holiday Inn Poplar Bluff by IHGPoplar Bluff
Stephanie
RM340
RM384 total
includes taxes & fees
13 Sept - 14 Sept
17. Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
JOAQUIN
RM400
RM434 total
includes taxes & fees
2 Oct - 3 Oct
18. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
ELAINE
RM409
RM465 total
includes taxes & fees
6 Sept - 7 Sept
19. Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
Raidas
RM291
RM328 total
includes taxes & fees
4 Oct - 5 Oct
20. Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
Chevonne
RM409
RM461 total
includes taxes & fees
4 Oct - 5 Oct
Holiday Rentals in Southeast Missouri
Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
"I really enjoyed my time at the stay !"
Cottage
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
'turtle Rock' - Ironton Cabin w/ Furnished Patio!Ironton
"Stroller, pack n play and high chair. This was amazing "
Holiday Home
Tiny Houses of French Village
Tiny Houses of French VillageFrench Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Aparthotel
The Atrium - A Boutique Hotel
The Atrium - A Boutique HotelPerryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor itemsโฆall was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
Cottage
Walk to Current River: Ozarks Adventure Home!
Walk to Current River: Ozarks Adventure Home!Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Cottage
Cozy Belgrade Cottage w/ Wood-burning Stove!
Cozy Belgrade Cottage w/ Wood-burning Stove!Belgrade
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Stay near popular Southeast Missouri attractions
Photo by Pat Long
Elephant Rocks State Park
9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Southeast Missouri State University
8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
Current River State Park
9.2/10 (20 reviews)
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Century Casino & Hotel Cape Girardeau
8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.
Century Casino Caruthersville
7.0/10 (57 reviews)
Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouriโwineries, a scenic riverfront and sights from K Bridge Recreation Area to Clearwater Lake.
See all hotels in Southeast Missouri
Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Pear Tree Inn Cape Girardeau West
10/10 Excellent
"Clean room friendly staff"
Best Western Plus Sikeston I-55
10/10 Excellent
"We were greeted with a warm smile from a really nice gentleman that checked us in. He chatted with us the entire time we checked in. He gave us ideas where to eat and Lamberts won. The hotel and room was very clean. Breakfast was great. They serve something hot everyday like biscuits and gravy, eggs, sausage and some days bacon. Highly recommend this hotel."
Drury Inn & Suites Sikeston, MO
10/10 Excellent
"Very nice and clean property."
Comfort Inn Festus - St Louis South
8/10 Good
"room was clean and the front staff was nice. place served it's purpose (stayed for only 2 nights). Not much amenitites."
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
10/10 Excellent
"Room was clean. Bed was a very comfortable best pillows Weโve had the whole trip . close to several different places to eat."
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
10/10 Excellent
"This location is a must stay any time I am traveling in the area. The staff are helpful. There are lots of dinning options near by. I can always count on a peaceful night sleep at this location."
Days Inn and Suites by Wyndham Sikeston
10/10 Excellent
"Front desk was welcoming and nice. Room was cleaned, beds were comfy. Very spacious. Quiet as well."
More cheap stays in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
RM230
RM250 total
13 Sept - 14 Sept
includes taxes & fees
8/10 Very good! (1,002 reviews)
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
RM268
RM306 total
5 Oct - 6 Oct
includes taxes & fees
7.2/10 Good! (1,000 reviews)
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
RM291
RM328 total
4 Oct - 5 Oct
includes taxes & fees
9.2/10 Wonderful! (1,002 reviews)
Comfort Inn Festus - St Louis South
1303 Veterans Blvd Festus MO
RM288
RM337 total
27 Sept - 28 Sept
includes taxes & fees
7.8/10 Good! (999 reviews)
The Farmstead Hotel
778 E 3rd St Caruthersville MO
RM384
RM437 total
5 Oct - 6 Oct
includes taxes & fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
RM409
RM465 total
6 Sept - 7 Sept
includes taxes & fees
9.4/10 Exceptional! (1,001 reviews)
4 Star Hotels
2 properties
3 Star Hotels
68 properties
2 Star Hotels
90 properties
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