𝗧𝗢𝗣 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 Southeast Missouri from RM250 (2026) - Fully Refundable Options

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Go beyond your typical stay in Southeast Missouri

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Cottage

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Our top choices for Southeast Missouri hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A hotel room with two beds, a lamp, and a painting on the wall.

A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

1. Shepherd Mountain Inn

Ironton

Michael

RM503

RM550 total

includes taxes & fees

20 Oct - 21 Oct

A motel with a covered entrance, a flag, and a phone number.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

2. Madison Inn Lodge

Fredericktown

Bawan

RM361

RM395 total

includes taxes & fees

20 Oct - 21 Oct

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

3. Hampton Inn & Suites By Hilton Festus

Festus

Abram

RM365

RM417 total

includes taxes & fees

29 Oct - 30 Oct

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

4. Super 8 by Wyndham Farmington

Farmington

Marisa

RM243

RM278 total

includes taxes & fees

26 Oct - 27 Oct

A modern living room with a sectional sofa, a coffee table, and a dining area with chairs and a table.

An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.

A hotel room with a bed, a sofa, a desk, and a chair.

A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.

5. Holiday Inn Express & Suites Farmington by IHG

Farmington

Sheila

RM482

RM551 total

includes taxes & fees

25 Oct - 26 Oct

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A gym with cardio equipment, a bench press, and a squat rack.

A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.

6. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Kim

RM219

RM250 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

An outdoor pool area with lounge chairs and an umbrella.

7. Fort Davidson Hotel

Ironton

richard

RM510

RM557 total

includes taxes & fees

20 Oct - 21 Oct

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.

A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

8. Crown Pointe Lodge, BW Signature Collection

Farmington

CURTIS

RM413

RM472 total

includes taxes & fees

19 Nov - 20 Nov

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

9. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Roslyn

RM412

RM469 total

includes taxes & fees

25 Oct - 26 Oct

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

A modern hotel lobby with multiple seating areas, a large flat-screen TV mounted on the wall, and a visible exit sign.

A reception desk with a wooden panel design, a bicycle mounted on the wall, and a sign reading "Hilton Honors".

A hotel room with two beds, a flat-screen TV, a desk, and a window with blinds.

10. Hampton Inn Farmington

Farmington

Charlie

RM416

RM476 total

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

11. Drury Inn & Suites Jackson MO

Jackson

Lyn

RM326

RM345 total

includes taxes & fees

1 Nov - 2 Nov

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

A corner market with a refrigerated display case and a pantry area.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

12. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

ELAINE

RM396

RM447 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

13. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Darnetta

RM408

RM460 total

includes taxes & fees

25 Oct - 26 Oct

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

14. The Riverview

Cape Girardeau

Scotty

RM467

RM526 total

includes taxes & fees

21 Oct - 22 Oct

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A reception area with a counter, vending machines, and a security camera.

A kitchen counter with a coffee machine, a kettle, and storage boxes.

A hotel lobby with seating areas, a television screen, and large windows.

15. Holiday Inn Express & Suites Perryville by IHG

Perryville

Perry

RM412

RM472 total

includes taxes & fees

1 Nov - 2 Nov

A living room with a blue wall, a fireplace, a sofa, and a chair.

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

A brick building with a sign reading "Mercantile & Hotel".

A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

16. EC Reed's Mercantile and Hotel

Marble Hill

Miranda

RM429

RM467 total

includes taxes & fees

22 Oct - 23 Oct

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.

17. Super 8 by Wyndham Perryville

Perryville

Matthew

RM278

RM318 total

includes taxes & fees

8 Nov - 9 Nov

A row of single-story houses with attached garages, a paved driveway, and a clear sky.

A modern living room with a flat-screen TV, a desk with a computer, two armchairs, a coffee table, and large windows with a view.

A hotel dining area with tables and chairs, a kitchen area, and a flat-screen TV mounted on the wall.

A reception desk with a digital map of the USA, a wooden reception area, and a sign for 'MICROHOTEL BY JYNDHAMI'.

18. Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

Samantha

RM342

RM402 total

includes taxes & fees

15 Nov - 16 Nov

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

19. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

RM413

RM466 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with two beds, a nightstand, and a wall-mounted light fixture.

A modern dining area with wooden tables and chairs, a mounted television, and a coffee station with various drink options.

A compact kitchen with a microwave, a sink, and a small refrigerator.

20. Hampton Inn Poplar Bluff

Poplar Bluff

Rhonda

RM371

RM416 total

includes taxes & fees

1 Nov - 2 Nov

View all properties

Holiday Rentals in Southeast Missouri

Cabin

A park entrance with a sign for Sam A. Baker State Park and Mudlick Mountain Store and Grill.

A view through a window with a stone wall and a wooden structure in the background.

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Cabin

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

A cabin with two Adirondack chairs outside, a picnic table, and a small black structure with a window and a sign.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"The stay here gets better every time."

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

A building with a sign that reads "The Atrium Boutique Hotel".

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A two-story house with a red exterior, a front porch, and a well-maintained lawn.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

A hallway with exposed brick walls, wooden flooring, and a white door.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

A spacious living room with wooden floors, a stone fireplace, and a mounted television.

A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.

A spacious living room with a wooden ceiling, a fireplace, and a television.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cottage

A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.

A spacious living area with a kitchen island, dining table, and a television.

A single-story house with a front porch, a stone foundation, and a well-maintained lawn.

A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

A spacious living area with a dark grey sofa set, a matching ottoman, and a wooden-paneled wall.

A house with a red door, a porch with rocking chairs, and a wreath on the door.

A two-story house with a deck and a covered porch.

A room with wooden paneling, a ceiling fan, a dining table with chairs, and a sofa.

40-acre Poplar Bluff Nature Lovers Paradise!

Poplar Bluff

"Beautiful place enjoyed our stay"

Cottage

A wooden deck with a hot tub, a small table, and a bench.

A bedroom with a sloped ceiling, a bed with a white and yellow bedspread, a wooden chair, a round rug, and a wooden wall with a window.

A rustic wooden interior with a dining table, chairs, a sofa, and a cowhide rug.

A rustic interior with a stone fireplace, wooden furniture, and a cozy seating area.

Hot Tub & Creek Views: Secluded Perryville Cabin

Perryville

"Such a perfect, nostalgic cabin. You literally have to see it to believe it. We will be back"

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

A dining area with a glass table and chairs, wooden flooring, and large windows.

A red house with a wooden deck, large sliding glass doors, and a chimney.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A bedroom with a bed, nightstand, lamp, and curtains.

A kitchen with granite countertops, white cabinets, a coffee maker, a kettle, and a sink.

A backyard with a wooden fence, two metal chairs, a metal table, and a house in the background.

A living room with a sofa, coffee table, TV stand, and ceiling fan.

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

See all holiday rentals

Hotels recommended for families in Southeast Missouri

Super 8 by Wyndham Farmington

Farmington

RM243

RM278 total

includes taxes & fees

26 Oct - 27 Oct

Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

RM219

RM250 total

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with a reception desk, seating area, and large windows.

A spacious conference room with brick walls, multiple tables and chairs, a large window, and a mounted TV.

A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.

An indoor swimming pool with a clear view of the outside through large windows.

Drury Inn & Suites Poplar Bluff

Poplar Bluff

RM384

RM433 total

includes taxes & fees

25 Oct - 26 Oct

Madison Inn Lodge

Fredericktown

RM361

RM395 total

includes taxes & fees

20 Oct - 21 Oct

Crown Pointe Lodge, BW Signature Collection

Farmington

RM413

RM472 total

includes taxes & fees

19 Nov - 20 Nov

Shepherd Mountain Inn

Ironton

RM503

RM550 total

includes taxes & fees

20 Oct - 21 Oct

Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

RM396

RM447 total

includes taxes & fees

1 Nov - 2 Nov

Holiday Inn Express & Suites Farmington by IHG

Farmington

RM482

RM551 total

includes taxes & fees

25 Oct - 26 Oct

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

See properties

A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

See properties

A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

See properties

Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Hampton Inn Poplar Bluff

10/10 Excellent

"Breakfast was great. Staff was helpful."

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Great stay! Hot tub was enjoyable and the staff was super friendly!"

Baymont Inn and Suites by Wyndham Farmington, MO

8/10 Good

"Room was clean, but humid. Breakfast was standard continental. Staff was nice. Good place to stay on a road trip or for work."

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Great service."

Drury Inn & Suites Hayti Caruthersville

8/10 Good

"Group of patrons were extremely loud at both dinner and breakfast was nnoi enjoyable n"

Hampton Inn Sikeston

8/10 Good

"Check in clerk was excellent. Room was clean but the bathroom shower made mold in the corners and bathroom floor needed cleaning. Everything else was fine."

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"A++++!"

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"We have stayed here frequently. Great place to stay."

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"We have stayed at the Pear Tree several times and never disappointed!! Great staff, clean rooms, generous breakfast. A special thanks to Lydia who took extra care to make our last stay remarkable. Thank you."

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

RM219

RM250 total

15 Nov - 16 Nov

includes taxes & fees

8/10 Very good! (1,009 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

RM271

RM308 total

2 Nov - 3 Nov

includes taxes & fees

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

RM290

RM325 total

2 Nov - 3 Nov

includes taxes & fees

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

RM294

RM331 total

25 Oct - 26 Oct

includes taxes & fees

9.2/10 Wonderful! (1,004 reviews)

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

RM294

RM343 total

19 Nov - 20 Nov

includes taxes & fees

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

RM371

RM416 total

1 Nov - 2 Nov

includes taxes & fees

9.4/10 Exceptional! (991 reviews)

Explore a world of travel with Expedia

Car hire Advance

Southeast Missouri hotels from RM250

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Shepherd Mountain Inn

2. Madison Inn Lodge

3. Hampton Inn & Suites By Hilton Festus

4. Super 8 by Wyndham Farmington

5. Holiday Inn Express & Suites Farmington by IHG

6. Baymont Inn and Suites by Wyndham Farmington, MO

7. Fort Davidson Hotel

8. Crown Pointe Lodge, BW Signature Collection

9. Fairfield Inn & Suites by Marriott Sikeston

10. Hampton Inn Farmington

11. Drury Inn & Suites Jackson MO

12. Fairfield Inn & Suites by Marriott Poplar Bluff

13. Drury Plaza Hotel Cape Girardeau Conference Center

14. The Riverview

15. Holiday Inn Express & Suites Perryville by IHG

16. EC Reed's Mercantile and Hotel

17. Super 8 by Wyndham Perryville

18. Microtel Inn & Suites by Wyndham Sainte Genevieve

19. Fairfield Inn & Suites by Marriott Cape Girardeau

20. Hampton Inn Poplar Bluff

Holiday Rentals in Southeast Missouri

Sam A Baker State Park

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

The Atrium - A Boutique Hotel

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Urban Lofts

Tiny Houses of French Village

Walk to Dtwn: Ironton Home in Historic District

Walk to Current River: Ozarks Adventure Home!

40-acre Poplar Bluff Nature Lovers Paradise!

Hot Tub & Creek Views: Secluded Perryville Cabin

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cottage w/ Yard, Walk to Historic Attractions

Hotels recommended for families in Southeast Missouri

Super 8 by Wyndham Farmington

Baymont Inn and Suites by Wyndham Farmington, MO

Drury Inn & Suites Poplar Bluff

Madison Inn Lodge

Crown Pointe Lodge, BW Signature Collection

Shepherd Mountain Inn

Fairfield Inn & Suites by Marriott Poplar Bluff

Holiday Inn Express & Suites Farmington by IHG

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Hampton Inn Poplar Bluff

Drury Plaza Hotel Cape Girardeau Conference Center

Baymont Inn and Suites by Wyndham Farmington, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Hayti Caruthersville

Hampton Inn Sikeston

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Pear Tree Inn Cape Girardeau West

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Days Inn and Suites by Wyndham Sikeston

Motel 6 Poplar Bluff, MO

Pear Tree Inn Cape Girardeau West

Comfort Inn Festus - St Louis South

Hampton Inn Poplar Bluff

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