Photo by Bill Dillard

Southeast Missouri hotels from RM226
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Our top choices for Southeast Missouri hotels

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,007 reviews)
The price is RM314
RM332 total
includes taxes & fees
16 Mar - 17 Mar

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (717 reviews)
The price is RM331
RM358 total
includes taxes & fees
10 Mar - 11 Mar

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (60 reviews)
The price is RM397
RM449 total
includes taxes & fees
12 Mar - 13 Mar

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,003 reviews)
The price is RM375
RM423 total
includes taxes & fees
15 Mar - 16 Mar

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.6 out of 10, Excellent, (502 reviews)
The price is RM269
RM306 total
includes taxes & fees
12 Mar - 13 Mar

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (998 reviews)
The price is RM371
RM419 total
includes taxes & fees
8 Mar - 9 Mar

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (875 reviews)
The price is RM434
RM490 total
includes taxes & fees
8 Mar - 9 Mar

The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (516 reviews)
The price is RM378
RM427 total
includes taxes & fees
10 Mar - 11 Mar

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,010 reviews)
The price is RM395
RM445 total
includes taxes & fees
9 Mar - 10 Mar

Fort Davidson Hotel
Fort Davidson HotelIronton
9.2 out of 10, Wonderful, (175 reviews)
The price is RM471
RM515 total
includes taxes & fees
6 Mar - 7 Mar

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,008 reviews)
The price is RM369
RM424 total
includes taxes & fees
10 Mar - 11 Mar

Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (113 reviews)
The price is RM383
RM436 total
includes taxes & fees
11 Mar - 12 Mar

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (162 reviews)
The price is RM399
RM450 total
includes taxes & fees
19 Mar - 20 Mar

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (562 reviews)
The price is RM438
RM501 total
includes taxes & fees
8 Mar - 9 Mar

Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (493 reviews)
The price is RM373
RM423 total
includes taxes & fees
29 Mar - 30 Mar

Echo Bluff State Park
Echo Bluff State ParkEminence
9.4 out of 10, Exceptional, (226 reviews)
The price is RM644
RM681 total
includes taxes & fees
5 Mar - 6 Mar

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (804 reviews)
The price is RM367
RM411 total
includes taxes & fees
15 Mar - 16 Mar

Arcadia Academy
Arcadia AcademyArcadia
9.8 out of 10, Exceptional, (11 reviews)
The price is RM535
RM580 total
includes taxes & fees
9 Mar - 10 Mar

Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (340 reviews)

Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau DowntownCape Girardeau
9.6 out of 10, Exceptional, (490 reviews)
The price is RM493
RM559 total
includes taxes & fees
13 Mar - 14 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (56 reviews)
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Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Clearwater Lake.

Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Cape Girardeau
10/10 Excellent
More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is RM226 per night from 10 Mar to 11 Mar
RM226
RM258 total
10 Mar - 11 Mar
includes taxes & fees
8/10 Very Good! (1,006 reviews)

4 Star Hotels
2 properties
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