Consider a stay at Best Western Plus Sikeston I-55 and take advantage of free full breakfast, a corner/local shop and shopping on-site. In addition to laundry facilities and a gym, guests can connect to free WiFi in public areas, with a speed of 25+ Mbps.
Sikeston is home to Best Western Plus Sikeston I-55. The area's natural beauty can be seen at Mississippi River and Central Park, while Sikeston Depot Museum and Front Street Studio & Art Gallery are cultural highlights. Visit our Sikeston travel guide
120 S Interstate Drive, Sikeston, MO, 63801
What's nearby
Southeast Missouri State University
30 min drive - 60.2 km
City of Miner Convention Center
16 min walk - 1.4 km
Sikeston Depot Museum
5 min drive - 7.3 km
Riverfront Park
29 min drive - 59.1 km
Century Casino & Hotel Cape Girardeau
31 min drive - 60.8 km
Getting around
Cairo, IL (CIR-Cairo Regional)
30 min drive
Restaurants
Lambert's Cafe
3 min drive
Buffalo Wild Wings
6 min drive
The 110 Grill
3 min drive
Pizza Inn
3 min drive
Starbucks
7 min drive
About this property
Best Western Plus Sikeston I-55
Property highlights
Take advantage of free full breakfast, a corner/local shop and shopping on-site at Best Western Plus Sikeston I-55. Stay connected with free WiFi in public areas, with a speed of 25+ Mbps, and guests can find other amenities, such as laundry facilities and a gym.
Additional perks include:
An indoor pool
Free self-parking
Express check-out, a computer station and laundry services
A water dispenser, a 24-hour front desk and a lift
Guest reviews say great things about the helpful staff and location
Room features
All 55 rooms offer comforts such as laptop-friendly workspaces and air conditioning, as well as perks such as high-speed Internet.
Extra conveniences in all rooms include:
Rollaway/extra beds (surcharge) and free cots/infant beds
Bathrooms with baths or showers and free toiletries
How much does it cost to stay at Best Western Plus Sikeston I-55?
As of 26 Oct 2026, prices found for a 1-night stay for 2 adults at Best Western Plus Sikeston I-55 on 8 Nov 2026 start from RM326, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.
Is Best Western Plus Sikeston I-55 pet-friendly?
Yes, pets are allowed at this property. There's a fee of USD 25.00 per pet, per night. Service animals are exempt from fees. Some restrictions may apply, so please contact the property for more details.
How much is parking at Best Western Plus Sikeston I-55?
Self-parking is free at this property.
What time is check-in at Best Western Plus Sikeston I-55?
Check-in start time: 3 PM; check-in end time: anytime.
What time is check-out at Best Western Plus Sikeston I-55?
Checkout is at 11 AM.
Where is Best Western Plus Sikeston I-55 located?
Situated in Sikeston, this hotel is 0.7 mi (1.2 km) from City of Miner Convention Center and within 6 miles (10 km) of Sikeston Depot Museum and Central Park. Front Street Studio & Art Gallery is 9 mi (14.5 km) away.
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Reviews
Best Western Plus Sikeston I-55 Reviews
8.4
Very good
All reviews shown are from real guest experiences. Only travellers who have booked a stay with us can submit a review. We verify reviews according to our guidelines and publish all reviews, positive or negative.More informationOpens in a new window
The room was big enough for three adults. The pool was nice and relaxing. My husband especially liked the breakfast as they served biscuits and gravy. We would definitely book this hotel again if the need arises.
Stayed 1 night in Jul 2026
Verified review
10/10 Excellent
Tabitha
20 May 2026
Liked: Cleanliness, staff & service
Breakfast was fresh and the room was clean. It's a good place to stay. Friendly staff.
Everything was well but the actual property was a little winding getting there (but i wasarriving at night) and there is not another business next to it, just a small lake, If you like that. Overall clean, nice and quiet. Nice breakfast room!
The physical facilities are not the standard of a Best Western. The room was clean and quiet. The location was close to the rodeo grounds and easy to find. The front desk person was efficient and pleasant. The breakfast had many choices, and the attendant was helpful to the guests.
Room was clean, the bathroom had a good vent and nice lighting which we've had a problem with with other hotels. Very satisfied with our stay and breakfast was gold.