Serra Mesa

San Diego


Popular places to visit

Things to do


Top hotels in Serra Mesa

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

3 out of 5
3888 Greenwood St, San Diego, CA
The price is RM551 per night from 26 Oct to 27 Oct
RM551
RM633 total
26 Oct - 27 Oct
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Popular attractions Mission Bay and Mission ...
9/10 Wonderful! (169 reviews)
"Beautiful facility. Quiet. Good breakfast"

Reviewed on 17 Oct 2025

Hampton Inn & Suites by Hilton San Diego SeaWorld
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
The price is RM1,010 per night from 29 Oct to 30 Oct
RM1,010
RM1,401 total
29 Oct - 30 Oct
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,855 reviews)
"We had a studio suite on the 38th floor and the view was amazing. It was a nice, spacious room, but the bathroom was so tiny and the bed was not very comfortable. The bellman mentioned that there are upgrades planned in the near future though..."

Reviewed on 17 Oct 2025

Manchester Grand Hyatt San Diego
Comfort Inn San Diego Airport At The Harbor

Comfort Inn San Diego Airport At The Harbor

3.5 out of 5
San Diego
The price is RM348 per night from 28 Oct to 29 Oct
RM348
RM394 total
28 Oct - 29 Oct
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, a rooftop terrace, and parking (surcharge). Our guests praise the helpful staff ...
7.8/10 Good! (1,073 reviews)
"I’ve not had breakfast yet,, checked in at 2, it’s now 8:55 pm"

Reviewed on 18 Oct 2025

Comfort Inn San Diego Airport At The Harbor
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
8.2/10 Very Good! (2,146 reviews)
"Clean"

Reviewed on 18 Oct 2025

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is RM571 per night from 26 Oct to 27 Oct
RM571
RM785 total
26 Oct - 27 Oct
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,984 reviews)
"Nice location and close to water front and cruise port."

Reviewed on 18 Oct 2025

Wyndham San Diego Bayside
Pendry San Diego

Pendry San Diego

5 out of 5
550 J Street, San Diego, CA
The price is RM1,120 per night from 9 Nov to 10 Nov
RM1,120
RM1,520 total
9 Nov - 10 Nov
includes taxes & fees
Stay at this 5-star luxury hotel in San Diego. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (1,019 reviews)
"The room was perfect, the shower soap, and lotions smelled so good I bought some to take home. Beautiful hotel and easy to walk around gaslamp without need for uber. Walkable to train and trolly also! The hotel bar was very classy and staff went above and beyond!"

Reviewed on 15 Oct 2025

Pendry San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Serra Mesa

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Mission Valley

4/5(36 area reviews)

Known for its stunning beaches and popular shops, there's plenty to explore in Mission Valley. Check out top attractions like Fashion Valley Mall and Snapdragon Stadium, and jump on the metro at Hazard Center Station or Mission Valley Center Station to see more of the city.

Mission Valley
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North Park

North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.

North Park
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Hillcrest

5/5(1 area review)

Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.

Hillcrest
Old Town San Diego State Park featuring signage

Old Town San Diego

4/5(5 area reviews)

The abundant dining options and seaside views are top of the list for many visitors to Old Town San Diego. A stop by Old Town San Diego State Park or Whaley House Museum might round out your trip.

Old Town San Diego
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Mid-City

While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.

Mid-City
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Little Italy

Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.

Little Italy