
Hotels in Serra Mesa, San Diego
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Serra Mesa hotels

Sycuan Casino Resort
Sycuan Casino Resort
Sheraton San Diego Resort
Sheraton San Diego Resort
Ramada by Wyndham San Diego Poway Miramar
Ramada by Wyndham San Diego Poway Miramar
San Diego Mission Bay Resort
San Diego Mission Bay Resort
Pleasant Inn
Pleasant Inn
Bahia Resort Hotel
Bahia Resort Hotel
Hilton Garden Inn San Diego Old Town/SeaWorld Area
Hilton Garden Inn San Diego Old Town/SeaWorld Area
Best Western Americana Inn
Best Western Americana Inn
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld
Bay Club Hotel & Marina
Bay Club Hotel & Marina
GreenTree Inn San Diego Mission Bay
GreenTree Inn San Diego Mission Bay
Comfort Inn San Diego Old Town
Comfort Inn San Diego Old Town
Paradise Point Resort & Spa
Paradise Point Resort & Spa
Ocean Beach Hotel
Ocean Beach Hotel
Holiday Inn Express San Diego Airport - Old Town by IHG
Holiday Inn Express San Diego Airport - Old Town by IHG
The Beau Hotel Gaslamp Quarter San Diego
The Beau Hotel Gaslamp Quarter San Diego
Best Western San Diego/Miramar Hotel
Best Western San Diego/Miramar Hotel
Kings Inn San Diego
Kings Inn San Diego
Best Western Plus Hacienda Hotel Old Town
Best Western Plus Hacienda Hotel Old TownWhere to stay in Serra Mesa

Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter
The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach
With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.
Top Serra Mesa Hotel Reviews

























































































