Hotels in Serra Mesa, San Diego
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Our top choices for Serra Mesa hotels
Wyndham San Diego Bayside
Wyndham San Diego Bayside9.9 km from Serra Mesa
8.4 out of 10, Very good, (5,994 reviews)
"Perfect location for cruise"
blasimar
The Bristol Hotel San Diego
The Bristol Hotel San Diego9.9 km from Serra Mesa
8.6 out of 10, Excellent, (1,469 reviews)
"Newly remodeled rooms, clean and wonderful staff. "
Zoe
San Diego Mission Bay Resort
San Diego Mission Bay ResortMission Bay, 7.2 km from Serra Mesa
8.4 out of 10, Very good, (1,336 reviews)
"Great place for our family getaway! Loved the S’mores on the beach! "
Dani
Paradise Point Resort & Spa
Paradise Point Resort & SpaMission Bay, 9.9 km from Serra Mesa
8.6 out of 10, Excellent, (2,366 reviews)
"Great facility and amenities. We look forward to taking our family back again. "
Andy
Sycuan Casino Resort
Sycuan Casino Resort28.8 km from Serra Mesa
9.2 out of 10, Wonderful, (1,671 reviews)
"Very clean resort. "
Petrina
Loews Coronado Bay Resort
Loews Coronado Bay Resort19.1 km from Serra Mesa
8.8 out of 10, Excellent, (1,063 reviews)
"The staff and amenities were spectacular. "
Andrew
Hard Rock Hotel San Diego
Hard Rock Hotel San DiegoGaslamp Quarter, 10.8 km from Serra Mesa
9.0 out of 10, Wonderful, (3,225 reviews)
"Great view easy checking in fun atmosphere and good food "
Sergio
The Dana on Mission Bay
The Dana on Mission BayMission Bay, 10.1 km from Serra Mesa
9.0 out of 10, Wonderful, (3,990 reviews)
"We had a wonderful stay!"
Megan
The DEXTRO Little Italy, BW Premier Collection
The DEXTRO Little Italy, BW Premier Collection9.3 km from Serra Mesa
9.0 out of 10, Wonderful, (911 reviews)
"Great stay. Would definitely stay again."
Zoraima
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San DiegoMarina District, 10.7 km from Serra Mesa
9.0 out of 10, Wonderful, (2,882 reviews)
"Excellent stay...wonderful staff"
Michelle
Humphreys Half Moon Inn
Humphreys Half Moon Inn12.3 km from Serra Mesa
9.2 out of 10, Wonderful, (2,738 reviews)
"Great stay, highly recommend."
Ryan
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Residence Inn by Marriott San Diego Downtown/Gaslamp QuarterGaslamp Quarter, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1,246 reviews)
"Friendly staff, great location, excellent value overall "
Maryann
GreenTree Inn San Diego Mission Bay
GreenTree Inn San Diego Mission BayPacific Beach, 7.3 km from Serra Mesa
8.0 out of 10, Very good, (1,902 reviews)
"The staff was very nice and great location"
Curtis
Embassy Suites by Hilton San Diego Bay Downtown
Embassy Suites by Hilton San Diego Bay DowntownMarina District, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1,576 reviews)
"Very easy vacation, convenient breakfast as well as location."
Kathy
Hampton Inn San Diego/Mission Valley
Hampton Inn San Diego/Mission Valley6.4 km from Serra Mesa
8.6 out of 10, Excellent, (1,364 reviews)
"Great breakfast-comfortable rooms-helpful staff-great location for events"
bill
The Sofia Hotel
The Sofia Hotel10 km from Serra Mesa
8.6 out of 10, Excellent, (1,689 reviews)
"Great location and history to the hotel "
Stephanie
DoubleTree by Hilton San Diego - Del Mar
DoubleTree by Hilton San Diego - Del MarCarmel Valley, 17.4 km from Serra Mesa
8.4 out of 10, Very good, (1,972 reviews)
"We had a great stay. The room was clean, the staff friendly and helpful, and the breakfast was excellent."
Christine
Margaritaville Hotel San Diego Gaslamp Quarter
Margaritaville Hotel San Diego Gaslamp QuarterGaslamp Quarter, 10.5 km from Serra Mesa
9.0 out of 10, Wonderful, (1,198 reviews)
"Perfect location in the Gaslamp District. Rooms were large & clean with friendly staff. "
Ginger
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld9 km from Serra Mesa
7.4 out of 10, Good, (4,131 reviews)
"Get location to the airport, safe, great staff, & overall wonderful stay"
Tyler
Best Western Seven Seas
Best Western Seven Seas5.3 km from Serra Mesa
8.0 out of 10, Very good, (3,125 reviews)
"Breakfast was good and the staff was friendly and excellent. "
Thuan
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Serra Mesa
Find the best Serra Mesa areas for the activities you enjoy most. Learn more about Serra Mesa
Learn more about Serra Mesa
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Gaslamp Quarter
The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.
Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Ocean Beach
With a secluded sunbathing beach, swimming-only beach, special surf beach, volleyball beach and dog beach, San Diego’s “OB” sure takes beaches seriously.
Top Serra Mesa Hotel Reviews
San Diego Mission Bay Resort
10/10 Excellent
