Top 10 Serra Mesa Hotels of 2026

A residential area with houses, roads, and a hilly landscape.

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Our top choices for Serra Mesa hotels

A modern bar area with wooden ceiling beams, bar stools, and a long counter.

1. Courtyard by Marriott San Diego Central

2.6 km from Serra Mesa

Nassim

RM651 total

includes taxes & fees

4 Oct - 5 Oct

An outdoor seating area with wicker chairs and a fire pit, surrounded by palm trees and string lights.

2. DoubleTree by Hilton Hotel San Diego - Mission Valley

4.2 km from Serra Mesa

Victor

RM648 total

includes taxes & fees

27 Sept - 28 Sept

An outdoor lounge area with seating, a fire feature, and a pool in the background.

3. Town and Country San Diego

5.3 km from Serra Mesa

Sol

RM1,129 total

includes taxes & fees

18 Sept - 19 Sept

A hotel reception area with a reception desk, framed pictures on the wall, a clock, and a seating area with a table and chairs.

4. Pleasant Inn

4.8 km from Serra Mesa

Vance Lee

RM385 total

includes taxes & fees

13 Sept - 14 Sept

A hotel lobby with a 'Lobby' sign, palm trees, and a sunset sky.

5. Best Western Seven Seas

5.3 km from Serra Mesa

Jamie

RM395 total

includes taxes & fees

13 Sept - 14 Sept

A modern hotel room with a large bed, bedside tables, a desk, and a wardrobe.

6. Holiday Inn Express San Diego Airport - Old Town by IHG

7.9 km from Serra Mesa

Faleoalii Iereneo

RM659 total

includes taxes & fees

23 Sept - 24 Sept

An outdoor seating area with a fire feature, surrounded by palm trees and modern buildings.

7. Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

6.4 km from Serra Mesa

Demetrius

RM637 total

includes taxes & fees

20 Sept - 21 Sept

An outdoor patio with a stone fire pit, outdoor seating, string lights, and a tall, narrow heater.

8. Embassy Suites by Hilton San Diego La Jolla

University City, 10.3 km from Serra Mesa

Sarineh

RM946 total

includes taxes & fees

13 Sept - 14 Sept

A hotel with a central courtyard, palm trees, and a fountain.

9. Hilton Garden Inn San Diego Old Town/SeaWorld Area

Old Town San Diego, 7.4 km from Serra Mesa

Edward Palacios

RM617 total

includes taxes & fees

27 Sept - 28 Sept

A spacious lobby with modern furniture, large windows, and a high ceiling with hanging lights.

10. Legacy Resort Hotel & Spa

5.8 km from Serra Mesa

amy

RM748 total

includes taxes & fees

23 Sept - 24 Sept

An outdoor patio area with tables and chairs, string lights, and a building with balconies.

11. Fairfield Inn & Suites San Diego Old Town

Old Town San Diego, 7.8 km from Serra Mesa

David

RM672 total

includes taxes & fees

27 Sept - 28 Sept

A spacious lobby with a large seating area, a wooden ceiling, and large windows offering a view of the outdoor patio area.

12. Hampton Inn & Suites San Diego Airport Liberty Station

10.6 km from Serra Mesa

David

RM877 total

includes taxes & fees

28 Sept - 29 Sept

A spacious living room with a large arched window, a red sofa, a coffee table, and a chandelier.

13. Lamplighter Inn & Suites at SDSU

8.4 km from Serra Mesa

Bernadette

RM602 total

includes taxes & fees

7 Oct - 8 Oct

A modern lobby with a stone wall, blue sofas, a reception desk, and a staircase.

14. Kings Inn San Diego

6 km from Serra Mesa

Armando

RM379 total

includes taxes & fees

13 Oct - 14 Oct

15. Best Western San Diego/Miramar Hotel

10.1 km from Serra Mesa

Jesus

RM507 total

includes taxes & fees

13 Sept - 14 Sept

16. Holiday Inn Express Hotel & Suites San Diego-Sorrento Valley by IHG

11.7 km from Serra Mesa

Johnathan

RM593 total

includes taxes & fees

13 Sept - 14 Sept

A pathway flanked by neatly trimmed hedges and a building with a balcony.

17. California Suites Hotel

4.8 km from Serra Mesa

Mathew

RM374 total

includes taxes & fees

14 Sept - 15 Sept

A bar area with a glass ceiling, a central bar counter, and multiple stools.

18. Lafayette Hotel & Club

5.3 km from Serra Mesa

Bryanna

RM1,165 total

includes taxes & fees

30 Sept - 1 Oct

A modern building with multiple windows, outdoor seating, and a chessboard.

19. Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

8.2 km from Serra Mesa

Joshua

RM725 total

includes taxes & fees

20 Sept - 21 Sept

A resort with a large swimming pool surrounded by lounge chairs and palm trees.

20. Handlery Hotel

5.7 km from Serra Mesa

Ronald

RM554 total

includes taxes & fees

7 Oct - 8 Oct

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Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most. Learn more about Serra Mesa

A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

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A pier at sunset with people sitting and standing, waves crashing below.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

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Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

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A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

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An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

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Top Serra Mesa Hotel Reviews

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

8/10 Good

"The staff was wonderful and helpful. I did have to have my room cleaned again however they were on it with no bad attitude. Outdoor pool was great. Breakfast was great, but mostly I would come back just for the staff."

Hotel del Coronado, Curio Collection by Hilton

8/10 Good

"This was our first visit to this resort and we found it to be a very enjoyable experience. Our room was very clean as well as the whole resort. The staff was very accommodating and eateries provided good quality food. The only negative was we found the gym to be somewhat small for such a large resort. Also the pool area would fill up really quickly, so finding a chair was a bit challenging at times."

Frequently asked questions

What's it like in Serra Mesa?

Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.

How many hotels can I expect to find in the Serra Mesa area?

Expedia has 40 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.

If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?

Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.

What can I see and do in this San Diego neighbourhood?

Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Sharp Learning Resource Center and Convoy District are also worth a stop.

Hotels in Serra Mesa, San Diego

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Our top choices for Serra Mesa hotels

1. Courtyard by Marriott San Diego Central

2. DoubleTree by Hilton Hotel San Diego - Mission Valley

3. Town and Country San Diego

4. Pleasant Inn

5. Best Western Seven Seas

6. Holiday Inn Express San Diego Airport - Old Town by IHG

7. Homewood Suites by Hilton San Diego Hotel Circle/SeaWorld Area

8. Embassy Suites by Hilton San Diego La Jolla

9. Hilton Garden Inn San Diego Old Town/SeaWorld Area

10. Legacy Resort Hotel & Spa

11. Fairfield Inn & Suites San Diego Old Town

12. Hampton Inn & Suites San Diego Airport Liberty Station

13. Lamplighter Inn & Suites at SDSU

14. Kings Inn San Diego

15. Best Western San Diego/Miramar Hotel

16. Holiday Inn Express Hotel & Suites San Diego-Sorrento Valley by IHG

17. California Suites Hotel

18. Lafayette Hotel & Club

19. Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

20. Handlery Hotel

Where to stay in Serra Mesa

Downtown San Diego

Pacific Beach

Gaslamp Quarter

Mission Beach

Mission Bay

Top Serra Mesa Hotel Reviews

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Frequently asked questions

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