Photo by JG Morris
Southeast Missouri Spa Hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Southeast Missouri Hotels with Spa
Our top choices for Southeast Missouri hotels with a spa
1. Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (1,009 reviews)
"Everything was great about the stay!"
Denise
The price is RM363
RM406 total
includes taxes & fees
6 Dec - 7 Dec
2. Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (1,001 reviews)
"Clean, great food, excellent staff."
Dean
The price is RM366
RM413 total
includes taxes & fees
13 Nov - 14 Nov
3. Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (977 reviews)
"Everything was great- breakfast, cleanliness, price— will stay there again"
ELAINE
The price is RM392
RM443 total
includes taxes & fees
7 Dec - 8 Dec
4. Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,002 reviews)
"Great stay! Hot tub was enjoyable and the staff was super friendly!"
Chris
The price is RM405
RM457 total
includes taxes & fees
11 Nov - 12 Nov
5. Hampton Inn By Hilton Dexter
Hampton Inn By Hilton DexterDexter
9.6 out of 10, Exceptional, (82 reviews)
"This place is Brand new and really great!"
Bryan
The price is RM396
RM449 total
includes taxes & fees
15 Nov - 16 Nov
6. EC Reed's Mercantile and Hotel
EC Reed's Mercantile and HotelMarble Hill
9.4 out of 10, Exceptional, (118 reviews)
"Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!"
Jan
The price is RM426
RM463 total
includes taxes & fees
6 Dec - 7 Dec
7. Holiday Inn Poplar Bluff by IHG
Holiday Inn Poplar Bluff by IHGPoplar Bluff
8.8 out of 10, Excellent, (805 reviews)
"Always an enjoyable stay"
Nathan
The price is RM321
RM363 total
includes taxes & fees
5 Dec - 6 Dec
8. The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (702 reviews)
"Every time I stay here I truly enjoy my stay
Clean rooms and staff is very attentive
Will stay here again"
Irvin
The price is RM463
RM522 total
includes taxes & fees
11 Nov - 12 Nov
9. Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MOPoplar Bluff
8.0 out of 10, Very good, (1,001 reviews)
"Rooms were large and clean. Bathroom was large with a nice shower. Parking was convenient Would definitely stay again."
Jim
The price is RM288
RM322 total
includes taxes & fees
1 Dec - 2 Dec
10. Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (118 reviews)
"Friendly staff, great breakfast, nice amenities"
Roslyn
The price is RM410
RM467 total
includes taxes & fees
15 Nov - 16 Nov
11. Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (199 reviews)
"Had a great stay friendly staff very clean facilities!"
Shannon
The price is RM346
RM394 total
includes taxes & fees
12 Nov - 13 Nov
12. Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.6 out of 10, Exceptional, (1,000 reviews)
"Awesome place will be staying in more of them"
Tim
The price is RM381
RM438 total
includes taxes & fees
6 Dec - 7 Dec
13. Shepherd Mountain Inn
Shepherd Mountain InnIronton
9.2 out of 10, Wonderful, (338 reviews)
"Clean room, wifi easy to connect to, parking right in front."
Jonathan
The price is RM501
RM547 total
includes taxes & fees
9 Nov - 10 Nov
14. Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau DowntownCape Girardeau
9.6 out of 10, Exceptional, (557 reviews)
"The staff was very friendly and rooms were great!"
Jacqueline
The price is RM472
RM534 total
includes taxes & fees
15 Nov - 16 Nov
15. Hampton Inn & Suites By Hilton Festus
Hampton Inn & Suites By Hilton FestusFestus
9.4 out of 10, Exceptional, (22 reviews)
"This was a wonderful hotel and had a wonderful stay. Room was clean and staff was wonderful."
Misty
The price is RM453
RM518 total
includes taxes & fees
15 Nov - 16 Nov
16. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
Rebecca
The price is RM385
RM438 total
includes taxes & fees
6 Dec - 7 Dec
17. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (891 reviews)
"Breakfast was good."
J
The price is RM325
RM351 total
includes taxes & fees
8 Nov - 9 Nov
18. Hampton Inn Cape Girardeau I 55 East
Hampton Inn Cape Girardeau I 55 EastCape Girardeau
9.6 out of 10, Exceptional, (858 reviews)
"Everything was lovely. Great room, breakfast, pool, and staff."
Vonnie
The price is RM395
RM446 total
includes taxes & fees
6 Dec - 7 Dec
19. Sam A Baker State Park
Sam A Baker State ParkPatterson
9.0 out of 10, Wonderful, (6 reviews)
"Pet friendly, great staff. "
Charlie
The price is RM548
RM581 total
includes taxes & fees
8 Nov - 9 Nov
20. Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (240 reviews)
"Great hotel…!!"
Carlos
The price is RM410
RM462 total
includes taxes & fees
22 Nov - 23 Nov
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southeast Missouri Hotel Reviews
Drury Inn & Suites Jackson MO
10/10 Excellent
Drury Inn & Suites Cape Girardeau
10/10 Excellent
Explore a world of travel with Expedia
- Belleview Hotels
- Bernie Hotels
- Black Hotels
- Bloomsdale Hotels
- Bunker Hotels
- Caravan Parks in Butler County
- Hotels with smoking rooms in Cape Girardeau
- Caravan Parks in Carter County
- De Soto Hotels
- Desloge Hotels
- Budget Hotels in Cape Girardeau County
- Pet friendly Hotels in Cape Girardeau County
- Lesterville Hotels
- Park Hills Hotels
- Qulin Hotels
- Caravan Parks in Ripley County
- Independent Hotels in Sikeston
- Sikeston Hotels
- B&B in Ste. Genevieve County
- Ste Genevieve Hotels
- Lodges in Washington County
- Flights to Bernie
- Flights from New Offenburg
- Flights from Qulin
- Flights from Tiff
- Flights from Accra (ACC) to Cape Girardeau (CGI)
- Flights from Alpine (ALE) to Cape Girardeau (CGI)
- Flights from Dallas (DFW) to Poplar Bluff (POF)
- Flights from Doha (DOH) to Cape Girardeau (CGI)
- Flights from Hagerstown (HGR) to Cape Girardeau (CGI)
- Flights from Wilmington (ILM) to Cape Girardeau (CGI)
- Flights from Kuala Lumpur (KUL) to Cape Girardeau (CGI)
- Flights from Columbus (LCK) to Cape Girardeau (CGI)
- Flights from Kansas City (MCI) to Cape Girardeau (CGI)
- Flights from Port of Spain (POS) to Cape Girardeau (CGI)
- Flights from San Antonio (SAT) to Poplar Bluff (POF)
- Flights from Valdosta (VLD) to Cape Girardeau (CGI)