B&B in Southeast Missouri
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A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

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your current months are November, 2026 and December, 2026.

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Our top choices for Southeast Missouri bed & breakfast

A stone building with a white porch and a small garden with yellow flowers.

A cozy seating area with wicker chairs and a coffee table, a brick wall, and a window with a view of greenery.

A narrow stone pathway leading to a brick house with a dark wooden door and a window with a white frame.

A vintage upright piano with a mirror above it, a lamp, and a floral wallpaper pattern.

1. Corner George Inn Bed & Breakfast

Corner George Inn Bed & Breakfast

2.5 star property

Maeystown

9.4 out of 10, Exceptional, (156 reviews)

9.4/10

Exceptional

(156 reviews)

"Hosts were excellent, very quiet and the breakfast was wonderful"

Mark

The price is RM522

RM522

RM579 total

includes taxes & fees

12 Nov - 13 Nov

Corner George Inn Bed & Breakfast

A large, two-story house with a wrap-around porch and a central tower.

A covered patio with a picnic table, surrounded by a brick pathway and greenery.

A four-poster canopy bed with a wooden headboard, a chandelier, and a radiator on the floor.

A room with a red velvet sofa, a chandelier, a mirror, and a vanity with a sink.

2. The Conner House B&B

The Conner House B&B

3.5 star property

Prairie du Rocher

10.0 out of 10, Exceptional, (22 reviews)

10/10

Exceptional

(22 reviews)

"A pitch perfect stay"

James

The price is RM634

RM634

RM704 total

includes taxes & fees

10 Nov - 11 Nov

The Conner House B&B

A multi-story wooden building with balconies and outdoor seating, likely a lodge or hotel.

A stone fireplace with a wooden mantel, surrounded by rustic decor and a wooden ceiling.

A rustic wooden interior with a wooden bench displaying various animal carvings and a stone wall.

A cozy bedroom with a stone fireplace, a bed with a patterned bedspread, and a television on a wooden stand.

3. The Lodge at Grant's Trail

The Lodge at Grant's Trail

3.5 star property

St. Louis

9.6 out of 10, Exceptional, (542 reviews)

9.6/10

Exceptional

(542 reviews)

"It was absolutely beautiful and welcoming definitely plan on coming back."

Sherri

The price is RM767

RM767

RM890 total

includes taxes & fees

16 Nov - 17 Nov

The Lodge at Grant's Trail

A rustic lodge with a steeply pitched roof, a central entrance with a door, and a porch with multiple lights.

A rustic building with a thatched roof, surrounded by dense greenery and a gravel path leading to it.

A cozy living room with a brown leather sofa, a wooden coffee table, and a window with a view of trees.

A stone building with a patio area, string lights, and outdoor seating.

4. Makanda Inn

Makanda Inn

3.5 star property

Makanda

10.0 out of 10, Exceptional, (41 reviews)

10/10

Exceptional

(41 reviews)

"Makanda inn is a very well maintained place. The room was very comfortable, and the staff was excellent. The breakfasts were delicious."

Thomas

The price is RM1,063

RM1,063

RM1,212 total

includes taxes & fees

10 Nov - 11 Nov

Makanda Inn

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

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Belleview Hotels
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Bernie Hotels
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Black Hotels
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Bloomsdale Hotels
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Bunker Hotels
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Caravan Parks in Butler County
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Hotels with smoking rooms in Cape Girardeau
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Caravan Parks in Carter County
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De Soto Hotels
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Desloge Hotels
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Budget Hotels in Cape Girardeau County
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Pet friendly Hotels in Cape Girardeau County
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Lesterville Hotels
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Park Hills Hotels
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Qulin Hotels
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Caravan Parks in Ripley County
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Independent Hotels in Sikeston
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B&B in Ste. Genevieve County
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Ste Genevieve Hotels
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Lodges in Washington County
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Flights to Bernie
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Flights from Qulin
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Flights from Accra (ACC) to Cape Girardeau (CGI)
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Flights from Alpine (ALE) to Cape Girardeau (CGI)
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Flights from Dallas (DFW) to Poplar Bluff (POF)
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Flights from Doha (DOH) to Cape Girardeau (CGI)
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Flights from Hagerstown (HGR) to Cape Girardeau (CGI)
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Flights from Wilmington (ILM) to Cape Girardeau (CGI)
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Flights from Kuala Lumpur (KUL) to Cape Girardeau (CGI)
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Flights from Columbus (LCK) to Cape Girardeau (CGI)
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Flights from Kansas City (MCI) to Cape Girardeau (CGI)
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Flights from Port of Spain (POS) to Cape Girardeau (CGI)
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Flights from San Antonio (SAT) to Poplar Bluff (POF)
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Flights from Valdosta (VLD) to Cape Girardeau (CGI)
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Visit Bloomsdale
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Cape Rock Park
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Felix Valle House State Historic Site
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Hawn State Park
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Visit Lithium
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Marble Hill Holidays
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Visit Park Hills
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Perryville Holidays
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Visit Qulin
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St. James Catholic Church
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Car hire Advance
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Search B&B in Southeast Missouri

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Southeast Missouri bed & breakfast

1. Corner George Inn Bed & Breakfast

2. The Conner House B&B

3. The Lodge at Grant's Trail

4. Makanda Inn

Learn more about Southeast Missouri

Explore a world of travel with Expedia