A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

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November 2026

December 2026

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Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

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Belleview Hotels
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Bernie Hotels
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Black Hotels
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Bloomsdale Hotels
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Bunker Hotels
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Caravan Parks in Butler County
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Hotels with smoking rooms in Cape Girardeau
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Caravan Parks in Carter County
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De Soto Hotels
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Desloge Hotels
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Budget Hotels in Cape Girardeau County
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Pet friendly Hotels in Cape Girardeau County
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Lesterville Hotels
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Park Hills Hotels
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Qulin Hotels
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Caravan Parks in Ripley County
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Independent Hotels in Sikeston
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Sikeston Hotels
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B&B in Ste. Genevieve County
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Ste Genevieve Hotels
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Lodges in Washington County
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Flights to Bernie
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Flights from New Offenburg
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Flights from Qulin
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Flights from Tiff
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Flights from Accra (ACC) to Cape Girardeau (CGI)
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Flights from Alpine (ALE) to Cape Girardeau (CGI)
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Flights from Dallas (DFW) to Poplar Bluff (POF)
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Flights from Doha (DOH) to Cape Girardeau (CGI)
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Flights from Hagerstown (HGR) to Cape Girardeau (CGI)
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Flights from Wilmington (ILM) to Cape Girardeau (CGI)
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Flights from Kuala Lumpur (KUL) to Cape Girardeau (CGI)
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Flights from Columbus (LCK) to Cape Girardeau (CGI)
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Flights from Kansas City (MCI) to Cape Girardeau (CGI)
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Flights from Port of Spain (POS) to Cape Girardeau (CGI)
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Flights from San Antonio (SAT) to Poplar Bluff (POF)
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Flights from Valdosta (VLD) to Cape Girardeau (CGI)
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Visit Bloomsdale
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Cape Rock Park
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Felix Valle House State Historic Site
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Hawn State Park
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Visit Lithium
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Marble Hill Holidays
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Visit Park Hills
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Perryville Holidays
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Visit Qulin
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St. James Catholic Church
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Car hire Advance
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Search Villas in Southeast Missouri

Change your mind

Treat yourself

Be picky

Find holiday rentals that suit your style

Check prices for these dates

Learn more about Southeast Missouri

Explore a world of travel with Expedia