Photo by Bill Dillard

Southeast Missouri hotels from RM213
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Check prices for these dates
Our top choices for Southeast Missouri hotels

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.8 out of 10, Excellent, (481 reviews)
The price is RM316
RM360 total
includes taxes & fees
5 Feb - 6 Feb

Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MOPoplar Bluff
8.0 out of 10, Very good, (1,000 reviews)
The price is RM224
RM236 total
includes taxes & fees
8 Feb - 9 Feb

Best Western Plus Sikeston I-55
Best Western Plus Sikeston I-55Sikeston
8.4 out of 10, Very good, (1,003 reviews)
The price is RM321
RM366 total
includes taxes & fees
15 Feb - 16 Feb

Super 8 By Wyndham Marston
Super 8 By Wyndham MarstonMarston
8.0 out of 10, Very good, (45 reviews)
The price is RM255
RM291 total
includes taxes & fees
5 Feb - 6 Feb

Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (337 reviews)
The price is RM378
RM409 total
includes taxes & fees
5 Feb - 6 Feb

New Orleans Inn Portageville
New Orleans Inn PortagevillePortageville
8.0 out of 10, Very good, (738 reviews)

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
The price is RM376
RM424 total
includes taxes & fees
22 Feb - 23 Feb

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,008 reviews)
The price is RM314
RM332 total
includes taxes & fees
9 Feb - 10 Feb

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)Sikeston
8.4 out of 10, Very good, (734 reviews)
The price is RM230
RM262 total
includes taxes & fees
5 Feb - 6 Feb

Super 8 by Wyndham Potosi
Super 8 by Wyndham PotosiPotosi
7.0 out of 10, Good, (383 reviews)
The price is RM217
RM237 total
includes taxes & fees
5 Feb - 6 Feb

The Riverstone Hotel
The Riverstone HotelCharleston
6.8 out of 10, (408 reviews)
The price is RM275
RM305 total
includes taxes & fees
5 Feb - 6 Feb

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.2 out of 10, Wonderful, (55 reviews)
The price is RM397
RM449 total
includes taxes & fees
12 Feb - 13 Feb

Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (108 reviews)
The price is RM351
RM400 total
includes taxes & fees
11 Feb - 12 Feb

Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (474 reviews)
The price is RM385
RM435 total
includes taxes & fees
22 Feb - 23 Feb

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (698 reviews)
The price is RM331
RM358 total
includes taxes & fees
8 Feb - 9 Feb

The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (496 reviews)
The price is RM381
RM430 total
includes taxes & fees
9 Feb - 10 Feb

Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHGSikeston
8.6 out of 10, Excellent, (447 reviews)
The price is RM393
RM445 total
includes taxes & fees
13 Feb - 14 Feb

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,000 reviews)
The price is RM354
RM407 total
includes taxes & fees
9 Feb - 10 Feb

Quality Inn Farmington
Quality Inn FarmingtonFarmington
7.6 out of 10, Good, (868 reviews)
The price is RM203
RM243 total
includes taxes & fees
22 Feb - 23 Feb

Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MOCharleston
6.8 out of 10, (622 reviews)
The price is RM244
RM271 total
includes taxes & fees
3 Mar - 4 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Cottage

40-acre Poplar Bluff Nature Lovers Paradise!
40-acre Poplar Bluff Nature Lovers Paradise!Poplar Bluff
10.0 out of 10, Exceptional, (3 reviews)
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Stay near popular Central United States attractions
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West
10/10 Excellent
More cheap stays in Southeast Missouri

Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
The price is RM224 per night from 8 Feb to 9 Feb
RM224
RM236 total
8 Feb - 9 Feb
includes taxes & fees
7.8/10 Good! (1,002 reviews)

4 Star Hotels
2 properties
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