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Our top choices for Southeast Missouri hotels

A motel with a covered entrance, a flag, and a phone number.

1. Madison Inn Lodge

Fredericktown

Bawan

RM377 total

includes taxes & fees

2 Nov - 3 Nov

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

2. Shepherd Mountain Inn

Ironton

Jonathan

RM547 total

includes taxes & fees

2 Nov - 3 Nov

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

3. Hampton Inn & Suites By Hilton Festus

Festus

Misty

RM525 total

includes taxes & fees

15 Nov - 16 Nov

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

4. Super 8 by Wyndham Farmington

Farmington

Marisa

RM276 total

includes taxes & fees

8 Nov - 9 Nov

A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.

5. Holiday Inn Express & Suites Farmington by IHG

Farmington

Sheila

RM521 total

includes taxes & fees

29 Nov - 30 Nov

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

6. Hampton Inn Farmington

Farmington

Charlie

RM466 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

7. Fort Davidson Hotel

Ironton

richard

RM554 total

includes taxes & fees

31 Oct - 1 Nov

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

8. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Kim

RM253 total

includes taxes & fees

9 Nov - 10 Nov

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

9. Crown Pointe Lodge, BW Signature Collection

Farmington

CURTIS

RM466 total

includes taxes & fees

31 Oct - 1 Nov

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

10. Drury Inn & Suites Jackson MO

Jackson

Lyn

RM343 total

includes taxes & fees

8 Nov - 9 Nov

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

11. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Roslyn

RM466 total

includes taxes & fees

8 Nov - 9 Nov

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

12. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

J

RM351 total

includes taxes & fees

8 Nov - 9 Nov

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

13. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Chris

RM458 total

includes taxes & fees

1 Nov - 2 Nov

A living room with a blue wall, a fireplace, a sofa, and a chair.

14. EC Reed's Mercantile and Hotel

Marble Hill

Jan

RM465 total

includes taxes & fees

4 Nov - 5 Nov

A modern hotel with a stone facade, multiple windows, outdoor seating, and a visible sign for the Holiday Inn Express & Suites.

15. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Festus

Terry

RM464 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

16. Super 8 by Wyndham Perryville

Perryville

Matthew

RM320 total

includes taxes & fees

15 Nov - 16 Nov

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

17. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

ELAINE

RM444 total

includes taxes & fees

29 Nov - 30 Nov

A row of single-story houses with attached garages, a paved driveway, and a clear sky.

18. Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

Samantha

RM413 total

includes taxes & fees

22 Nov - 23 Nov

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

19. The Riverview

Cape Girardeau

Renee

RM523 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a reception desk, seating area, and large windows.

20. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Dean

RM413 total

includes taxes & fees

13 Nov - 14 Nov

View all properties

Compare top hotels in Southeast Missouri

Madison Inn Lodge 2.5 star property Fredericktown View	Shepherd Mountain Inn 2.5 star property Ironton View	Hampton Inn & Suites By Hilton Festus Festus View	Super 8 by Wyndham Farmington 2.0 star property Farmington View	Holiday Inn Express & Suites Farmington by IHG 2.5 star property Farmington View
7.6 Good 314 reviews	9.2 Wonderful 337 reviews	9.4 Exceptional 21 reviews	8.0 Very good 690 reviews	8.6 Excellent 442 reviews
The price is RM345 RM377 total includes taxes & fees 2 Nov - 3 Nov	The price is RM501 RM547 total includes taxes & fees 2 Nov - 3 Nov	The price is RM459 RM525 total includes taxes & fees 15 Nov - 16 Nov	The price is RM242 RM276 total includes taxes & fees 8 Nov - 9 Nov	The price is RM451 RM521 total includes taxes & fees 29 Nov - 30 Nov
Yes, Breakfast included Yes, Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included No Pool No Spa No Pet-friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa Yes, Pet-friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa No Pet-friendly Yes, WiFi included Yes, Parking	Yes, Breakfast included Yes, Pool No Spa No Pet-friendly Yes, WiFi included Yes, Parking

Holiday Rentals in Southeast Missouri

Cabin

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"Recomend this location"

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A log cabin with a glass door leading to an outdoor patio, a grill, and a table with chairs.

Peaceful 2-cabin Property: 1 Mi to Current River!

Van Buren

"We had the best time. We had plenty of room for our families that were in town for a wedding. The rental had everything we needed."

Cottage

A bedroom with a bed, nightstand, lamp, and curtains.

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

See all holiday rentals

Hotels recommended for families in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

RM253 total

includes taxes & fees

9 Nov - 10 Nov

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

See properties

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri