𝗧𝗢𝗣 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 Southeast Missouri from RM255 (2026) - Fully Refundable Options

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Go beyond your typical stay in Southeast Missouri

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Cottage

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Our top choices for Southeast Missouri hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A hotel room with two beds, a lamp, and a painting on the wall.

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.

1. Shepherd Mountain Inn

Ironton

Michael

RM502

RM548 total

includes taxes & fees

16 Sept - 17 Sept

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

2. Drury Inn & Suites Sikeston, MO

Sikeston

Scott Andrew

RM452

RM519 total

includes taxes & fees

4 Oct - 5 Oct

A motel with a covered entrance, a flag, and a phone number.

A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

3. Madison Inn Lodge

Fredericktown

Bawan

RM356

RM389 total

includes taxes & fees

26 Sept - 27 Sept

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

4. Fort Davidson Hotel

Ironton

richard

RM509

RM556 total

includes taxes & fees

16 Sept - 17 Sept

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

5. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

RM407

RM459 total

includes taxes & fees

27 Sept - 28 Sept

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

6. Hampton Inn Poplar Bluff

Poplar Bluff

Theresa

RM381

RM427 total

includes taxes & fees

4 Oct - 5 Oct

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.

A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.

7. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

ELAINE

RM411

RM468 total

includes taxes & fees

20 Sept - 21 Sept

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A reception desk with a bicycle light, potted plants, and a 'Connect & Print' sign.

A corner market with a refrigerated display case and a pantry area.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

8. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Arsenia

RM412

RM465 total

includes taxes & fees

4 Oct - 5 Oct

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

A hotel room with two beds, a nightstand, a lamp, and a chair.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

An outdoor patio with tables and chairs, a stone wall, and large windows.

9. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Elaine

RM377

RM408 total

includes taxes & fees

17 Sept - 18 Sept

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

10. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

RM412

RM464 total

includes taxes & fees

20 Sept - 21 Sept

A rustic log cabin with a stone foundation, surrounded by trees and a wooden fence.

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

A view through a window with a stone wall and a wooden structure in the background.

A compact kitchen with wooden cabinets, a dishwasher, a refrigerator, and a coffee maker.

11. Sam A Baker State Park

Patterson

Charlie

RM715

RM758 total

includes taxes & fees

16 Sept - 17 Sept

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A hotel room with two beds, a brick wall, and a wooden headboard.

12. Drury Inn & Suites Jackson MO

Jackson

William

RM326

RM345 total

includes taxes & fees

21 Sept - 22 Sept

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

13. Super 8 by Wyndham Farmington

Farmington

Marisa

RM242

RM264 total

includes taxes & fees

28 Sept - 29 Sept

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

14. Hampton Inn Sikeston

Sikeston

Jeffrey

RM414

RM469 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

15. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Raidas

RM293

RM331 total

includes taxes & fees

27 Sept - 28 Sept

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

16. Crown Pointe Lodge, BW Signature Collection

Farmington

Susan

RM446

RM486 total

includes taxes & fees

21 Sept - 22 Sept

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A kitchenette with a coffee machine, a kettle, and storage shelves.

A buffet with various food items, including omelets and baked goods, served in metal containers.

An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.

17. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

michael

RM427

RM484 total

includes taxes & fees

11 Oct - 12 Oct

A red wooden mill with a small bridge over a flowing river, surrounded by lush greenery.

A row of yellow buildings with white railings and a covered front porch.

A dining area with a round table and chairs, large windows with curtains, and a whiteboard on the wall.

A playground with a slide, climbing structures, and a small shelter.

18. Honeysuckle Inn - Mountain View

Mountain View

Joanne

RM403

RM437 total

includes taxes & fees

2 Oct - 3 Oct

A narrow corridor with a bar area on the right, featuring a counter and hanging lights.

A large boulder in a natural setting with autumn-colored trees in the background.

A room with a wooden floor, a bed, a desk with a coffee maker, a mirror, and a sliding door leading to a bathroom.

19. Black River Motel and Restaurant

Lesterville

Douglas

RM473

RM500 total

includes taxes & fees

16 Sept - 17 Sept

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

20. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

RM411

RM465 total

includes taxes & fees

27 Sept - 28 Sept

View all properties

Holiday Rentals in Southeast Missouri

Cabin

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"I really enjoyed my time at the stay !"

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

A two-story house with a red exterior, a front porch, and a well-maintained lawn.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Cabin

A wooden deck with a railing leading to a building with a metal roof and a brown door.

A calm lake with a wooden dock and a forested island in the distance.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.

A spacious living room with wooden floors, a stone fireplace, and a mounted television.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A building with a sign that reads "The Atrium Boutique Hotel".

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Cottage

A wooden deck leading to a house with a wooden door and a small porch area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

A spacious living area with a dark grey sofa set, a matching ottoman, and a wooden-paneled wall.

A house with a red door, a porch with rocking chairs, and a wreath on the door.

A spacious dining area with a stone wall, wooden furniture, and a fireplace.

A room with wooden paneling, a ceiling fan, a dining table with chairs, and a sofa.

40-acre Poplar Bluff Nature Lovers Paradise!

Poplar Bluff

"Beautiful place enjoyed our stay"

Cottage

A cozy living room with wooden ceilings, a ceiling fan, two sofas, a coffee table, a rug, and a bookshelf with books and games.

A red house with a wooden deck and stone steps leading to a porch.

A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

A red house with a wooden deck, large sliding glass doors, and a chimney.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A bedroom with a bed, nightstand, lamp, and curtains.

A backyard with a wooden fence, two metal chairs, a metal table, and a house in the background.

A single-story house with a front porch, a small front yard, and a red roof.

A kitchen with granite countertops, white cabinets, a coffee maker, a kettle, and a sink.

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

See all holiday rentals

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

See properties

A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

See properties

A river flowing through a forested area with a sandy beach.

Big Spring

9.8/10 (19 reviews)

Enjoy an outing to Big Spring during your stay in Van Buren. Wander the forests and riverfront while you're in the area.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

See properties

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Clean room, nice comfortable beds. It was very quiet and we felt very safe. The only drawback was the toilet was too low."

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"Clean, good location, comfortable beds"

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"We've stayed here twice & each time the property is well maintained, clean & the staff are very friendly. Would definitely recommend to anyone!"

Days Inn and Suites by Wyndham Sikeston

8/10 Good

"The room did not have an extra roll of toilet paper and also the hairdryer did not work. That was the only two things that was not. I was not happy with."

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Great experience- food, cleanliness, friendly staff"

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"This was the perfect stress free getaway. 10 minutes from a gas station and some fast food. 20 minutes from at least 2 cute towns and 3 wineries. It felt quiet without feeling isolated. The cabin was perfectly appointed with everything we needed, including firewood, starters, and lighters. We hope to go back!"

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Excellent breakfast,friendly staff and clean rooms"

Holiday Inn Express & Suites Perryville by IHG

8/10 Good

"Clean and nice. Late check in but staff was very helpful and quick. Bedding was nice, mattress was more firm than I like but not uncomfortable."

Fairfield Inn & Suites by Marriott Cape Girardeau

10/10 Excellent

"The receptionist was very courteous. Helped answer all my questions. We loved the room. And we had a great breakfast before we left."

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

RM234

RM255 total

28 Sept - 29 Sept

includes taxes & fees

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

RM270

RM308 total

17 Sept - 18 Sept

includes taxes & fees

7.2/10 Good! (1,002 reviews)

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

RM293

RM331 total

27 Sept - 28 Sept

includes taxes & fees

9.2/10 Wonderful! (1,007 reviews)

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

RM313

RM366 total

11 Oct - 12 Oct

includes taxes & fees

7.8/10 Good! (1,005 reviews)

The Farmstead Hotel

778 E 3rd St Caruthersville MO

RM387

RM440 total

5 Oct - 6 Oct

includes taxes & fees

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

RM411

RM468 total

20 Sept - 21 Sept

includes taxes & fees

9.4/10 Exceptional! (1,002 reviews)

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Car hire Advance

Southeast Missouri hotels from RM255

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Shepherd Mountain Inn

2. Drury Inn & Suites Sikeston, MO

3. Madison Inn Lodge

4. Fort Davidson Hotel

5. Drury Plaza Hotel Cape Girardeau Conference Center

6. Hampton Inn Poplar Bluff

7. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

8. Fairfield Inn & Suites by Marriott Poplar Bluff

9. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10. Fairfield Inn & Suites by Marriott Cape Girardeau

11. Sam A Baker State Park

12. Drury Inn & Suites Jackson MO

13. Super 8 by Wyndham Farmington

14. Hampton Inn Sikeston

15. Pear Tree Inn Cape Girardeau West

16. Crown Pointe Lodge, BW Signature Collection

17. Holiday Inn Express & Suites Sikeston Southwest by IHG

18. Honeysuckle Inn - Mountain View

19. Black River Motel and Restaurant

20. Fairfield Inn & Suites by Marriott Sikeston

Holiday Rentals in Southeast Missouri

Sam A Baker State Park

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Lake Wappapello

Tiny Houses of French Village

The Atrium - A Boutique Hotel

Urban Lofts

Walk to Current River: Ozarks Adventure Home!

40-acre Poplar Bluff Nature Lovers Paradise!

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cottage w/ Yard, Walk to Historic Attractions

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Big Spring

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Drury Inn & Suites Sikeston, MO

Days Inn and Suites by Wyndham Sikeston

Drury Plaza Hotel Cape Girardeau Conference Center

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express & Suites Perryville by IHG

Fairfield Inn & Suites by Marriott Cape Girardeau

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau West

Comfort Inn Festus - St Louis South

The Farmstead Hotel

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

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