Photo by Bill Dillard

Southeast Missouri hotels from RM226
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Our top choices for Southeast Missouri hotels

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,009 reviews)
The price is RM316
RM334 total
includes taxes & fees
15 Mar - 16 Mar

The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (524 reviews)
The price is RM380
RM429 total
includes taxes & fees
15 Mar - 16 Mar

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (63 reviews)
The price is RM399
RM451 total
includes taxes & fees
19 Mar - 20 Mar

Echo Bluff State Park
Echo Bluff State ParkEminence
9.4 out of 10, Exceptional, (227 reviews)
The price is RM726
RM768 total
includes taxes & fees
10 Mar - 11 Mar

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (719 reviews)
The price is RM332
RM360 total
includes taxes & fees
12 Mar - 13 Mar

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (1,003 reviews)
The price is RM371
RM419 total
includes taxes & fees
15 Mar - 16 Mar

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,007 reviews)
The price is RM391
RM441 total
includes taxes & fees
29 Mar - 30 Mar

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,017 reviews)
The price is RM395
RM445 total
includes taxes & fees
15 Mar - 16 Mar

Century Casino & Hotel Caruthersville
Century Casino & Hotel CaruthersvilleCaruthersville
8.6 out of 10, Excellent, (127 reviews)
The price is RM480
RM546 total
includes taxes & fees
10 Mar - 11 Mar

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.6 out of 10, Excellent, (507 reviews)
The price is RM300
RM341 total
includes taxes & fees
10 Mar - 11 Mar

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,014 reviews)
The price is RM371
RM427 total
includes taxes & fees
15 Mar - 16 Mar

Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (592 reviews)
The price is RM366
RM416 total
includes taxes & fees
16 Mar - 17 Mar

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (164 reviews)
The price is RM399
RM451 total
includes taxes & fees
19 Mar - 20 Mar

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (56 reviews)
The price is RM371
RM569 total
includes taxes & fees
16 Mar - 17 Mar

Days Inn & Suites By Wyndham Festus
Days Inn & Suites By Wyndham FestusFestus
The price is RM373
RM427 total
includes taxes & fees
15 Mar - 16 Mar

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (876 reviews)
The price is RM434
RM491 total
includes taxes & fees
15 Mar - 16 Mar

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (563 reviews)
The price is RM407
RM466 total
includes taxes & fees
5 Apr - 6 Apr

Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (114 reviews)
The price is RM385
RM438 total
includes taxes & fees
15 Mar - 16 Mar

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (805 reviews)
The price is RM369
RM413 total
includes taxes & fees
15 Mar - 16 Mar

Super 8 by Wyndham Perryville
Super 8 by Wyndham PerryvillePerryville
8.4 out of 10, Very good, (962 reviews)
The price is RM272
RM311 total
includes taxes & fees
5 Apr - 6 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (56 reviews)
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Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Photo by Bill Dillard
Open Photo by Bill Dillard
More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is RM231 per night from 16 Mar to 17 Mar
RM231
RM262 total
16 Mar - 17 Mar
includes taxes & fees
8/10 Very Good! (1,010 reviews)

4 Star Hotels
2 properties
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