Photo by Bill Dillard

Southeast Missouri hotels from RM227
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Southeast Missouri
Family friendly
Apartment
Check prices for these dates
Our top choices for Southeast Missouri hotels

Echo Bluff State Park
Echo Bluff State ParkEminence
9.6 out of 10, Exceptional, (243 reviews)
The price is RM730
RM771 total
includes taxes & fees
27 Apr - 28 Apr

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,001 reviews)
The price is RM321
RM340 total
includes taxes & fees
14 May - 15 May

Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (347 reviews)
The price is RM378
RM410 total
includes taxes & fees
28 Apr - 29 Apr

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (177 reviews)
The price is RM367
RM414 total
includes taxes & fees
7 May - 8 May

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (62 reviews)
The price is RM333
RM529 total
includes taxes & fees
27 May - 28 May

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,002 reviews)
The price is RM396
RM447 total
includes taxes & fees
3 May - 4 May

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (890 reviews)
The price is RM436
RM493 total
includes taxes & fees
28 Apr - 29 Apr

Arcadia Academy
Arcadia AcademyArcadia
9.8 out of 10, Exceptional, (12 reviews)
The price is RM540
RM586 total
includes taxes & fees
27 Apr - 28 Apr

Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (609 reviews)
The price is RM435
RM473 total
includes taxes & fees
24 May - 25 May

EC Reed's Mercantile and Hotel
EC Reed's Mercantile and HotelMarble Hill
9.6 out of 10, Exceptional, (87 reviews)
The price is RM371
RM403 total
includes taxes & fees
27 Apr - 28 Apr

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (1,001 reviews)
The price is RM381
RM430 total
includes taxes & fees
3 May - 4 May

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.6 out of 10, Exceptional, (1,005 reviews)
The price is RM440
RM506 total
includes taxes & fees
1 May - 2 May

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (580 reviews)
The price is RM400
RM458 total
includes taxes & fees
30 Apr - 1 May

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (72 reviews)
The price is RM436
RM494 total
includes taxes & fees
7 May - 8 May

Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (122 reviews)
The price is RM387
RM440 total
includes taxes & fees
4 May - 5 May

Shepherd Mountain Inn
Shepherd Mountain InnIronton
9.4 out of 10, Exceptional, (311 reviews)
The price is RM428
RM468 total
includes taxes & fees
27 Apr - 28 Apr

Lake Wappapello
Lake WappapelloWilliamsville
10.0 out of 10, Exceptional, (2 reviews)
The price is RM337
RM355 total
includes taxes & fees
27 Apr - 28 Apr

Super 8 by Wyndham Perryville
Super 8 by Wyndham PerryvillePerryville
8.4 out of 10, Very good, (984 reviews)
The price is RM263
RM301 total
includes taxes & fees
7 May - 8 May

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (824 reviews)
The price is RM371
RM415 total
includes taxes & fees
3 May - 4 May

Fort Davidson Hotel
Fort Davidson HotelIronton
9.2 out of 10, Wonderful, (176 reviews)
The price is RM496
RM541 total
includes taxes & fees
27 Apr - 28 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (62 reviews)
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Central United States attractions
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Photo by Bill Dillard
Open Photo by Bill Dillard
More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is RM241 per night from 7 May to 8 May
RM241
RM262 total
7 May - 8 May
includes taxes & fees
8/10 Very Good! (1,005 reviews)

4 Star Hotels
2 properties
Explore a world of travel with Expedia
- Belleview Hotels
- Bernie Hotels
- Black Hotels
- Bloomsdale Hotels
- Bunker Hotels
- Caravan Parks in Butler County
- Hotels with smoking rooms in Cape Girardeau
- Caravan Parks in Carter County
- De Soto Hotels
- Desloge Hotels
- Budget Hotels in Cape Girardeau County
- Pet friendly Hotels in Cape Girardeau County
- Lesterville Hotels
- Park Hills Hotels
- Qulin Hotels
- Caravan Parks in Ripley County
- Independent Hotels in Sikeston
- Sikeston Hotels
- B&B in Ste. Genevieve County
- Ste Genevieve Hotels
- Lodges in Washington County
- Flights to Bernie
- Flights from New Offenburg
- Flights from Qulin
- Flights from Tiff
- Flights from Accra (ACC) to Cape Girardeau (CGI)
- Flights from Alpine (ALE) to Cape Girardeau (CGI)
- Flights from Dallas (DFW) to Poplar Bluff (POF)
- Flights from Doha (DOH) to Cape Girardeau (CGI)
- Flights from Hagerstown (HGR) to Cape Girardeau (CGI)
- Flights from Wilmington (ILM) to Cape Girardeau (CGI)
- Flights from Kuala Lumpur (KUL) to Cape Girardeau (CGI)
- Flights from Columbus (LCK) to Cape Girardeau (CGI)
- Flights from Kansas City (MCI) to Cape Girardeau (CGI)
- Flights from Port of Spain (POS) to Cape Girardeau (CGI)
- Flights from San Antonio (SAT) to Poplar Bluff (POF)
- Flights from Valdosta (VLD) to Cape Girardeau (CGI)
















































































































