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Southeast Missouri hotels from RM255

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Check prices for these dates

Tonight
15 Sept - 16 Sept
Tomorrow
16 Sept - 17 Sept
This weekend
18 Sept - 20 Sept
Next weekend
25 Sept - 27 Sept

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Our top choices for Southeast Missouri hotels

1. Shepherd Mountain Inn

Shepherd Mountain Inn
Ironton
United States
Michael
RM502
RM548 total
includes taxes & fees
16 Sept - 17 Sept
Shepherd Mountain Inn

2. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston
United States
Scott Andrew
RM452
RM519 total
includes taxes & fees
4 Oct - 5 Oct
Drury Inn & Suites Sikeston, MO

3. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
RM356
RM389 total
includes taxes & fees
26 Sept - 27 Sept
Madison Inn Lodge

4. Fort Davidson Hotel

Fort Davidson Hotel
Ironton
United States
richard
RM509
RM556 total
includes taxes & fees
16 Sept - 17 Sept
Fort Davidson Hotel

5. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Sandra
RM407
RM459 total
includes taxes & fees
27 Sept - 28 Sept
Drury Plaza Hotel Cape Girardeau Conference Center

6. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Theresa
RM381
RM427 total
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn Poplar Bluff

7. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
United States
ELAINE
RM411
RM468 total
includes taxes & fees
20 Sept - 21 Sept
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

8. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
Poplar Bluff
United States
Arsenia
RM412
RM465 total
includes taxes & fees
4 Oct - 5 Oct
Fairfield Inn & Suites by Marriott Poplar Bluff

9. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
United States
Elaine
RM377
RM408 total
includes taxes & fees
17 Sept - 18 Sept
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
United States
Carlos
RM412
RM464 total
includes taxes & fees
20 Sept - 21 Sept
Fairfield Inn & Suites by Marriott Cape Girardeau

11. Sam A Baker State Park

Sam A Baker State Park
Patterson
United States
Charlie
RM715
RM758 total
includes taxes & fees
16 Sept - 17 Sept
Sam A Baker State Park

12. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
William
RM326
RM345 total
includes taxes & fees
21 Sept - 22 Sept
Drury Inn & Suites Jackson MO

13. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
Farmington
United States
Marisa
RM242
RM264 total
includes taxes & fees
28 Sept - 29 Sept
Super 8 by Wyndham Farmington

14. Hampton Inn Sikeston

Hampton Inn Sikeston
Sikeston
United States
Jeffrey
RM414
RM469 total
includes taxes & fees
11 Oct - 12 Oct
Hampton Inn Sikeston

15. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
Canada
Raidas
RM293
RM331 total
includes taxes & fees
27 Sept - 28 Sept
Pear Tree Inn Cape Girardeau West

16. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
Susan
RM446
RM486 total
includes taxes & fees
21 Sept - 22 Sept
Crown Pointe Lodge, BW Signature Collection

17. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
Sikeston
United States
michael
RM427
RM484 total
includes taxes & fees
11 Oct - 12 Oct
Holiday Inn Express & Suites Sikeston Southwest by IHG

18. Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
Mountain View
United States
Joanne
RM403
RM437 total
includes taxes & fees
2 Oct - 3 Oct
Honeysuckle Inn - Mountain View

19. Black River Motel and Restaurant

Black River Motel and Restaurant
Lesterville
United States
Douglas
RM473
RM500 total
includes taxes & fees
16 Sept - 17 Sept
Black River Motel and Restaurant

20. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
RM411
RM465 total
includes taxes & fees
27 Sept - 28 Sept
Fairfield Inn & Suites by Marriott Sikeston
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Holiday Rentals in Southeast Missouri

Cabin

Sam A Baker State Park

Sam A Baker State Park
Patterson
"Pet friendly, great staff. "
Sam A Baker State Park
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village
"I really enjoyed my time at the stay !"
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Cottage

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Ironton
"Stroller, pack n play and high chair. This was amazing "
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Cabin

Lake Wappapello

Lake Wappapello
Williamsville
"Pet friendly. Family-friendly "
Lake Wappapello
Holiday Home

Tiny Houses of French Village

Tiny Houses of French Village
French Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Tiny Houses of French Village
Aparthotel

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
Perryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor itemsโ€ฆall was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
The Atrium - A Boutique Hotel
Aparthotel

Urban Lofts

Urban Lofts
Perryville
"Beautiful place and staff was amazing!"
Urban Lofts
Cottage

Walk to Current River: Ozarks Adventure Home!

Walk to Current River: Ozarks Adventure Home!
Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Walk to Current River: Ozarks Adventure Home!
Cottage

40-acre Poplar Bluff Nature Lovers Paradise!

40-acre Poplar Bluff Nature Lovers Paradise!
Poplar Bluff
"Beautiful place enjoyed our stay"
40-acre Poplar Bluff Nature Lovers Paradise!
Cottage

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cozy Belgrade Cottage w/ Wood-burning Stove!
Belgrade
Cozy Belgrade Cottage w/ Wood-burning Stove!
Cottage

Cottage w/ Yard, Walk to Historic Attractions

Cottage w/ Yard, Walk to Historic Attractions
Ste Genevieve
"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "
Cottage w/ Yard, Walk to Historic Attractions
See all holiday rentals
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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
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A river flowing through a forested area with a sandy beach.

Big Spring

9.8/10 (19 reviews)
Enjoy an outing to Big Spring during your stay in Van Buren. Wander the forests and riverfront while you're in the area.
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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.
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Century Casino Caruthersville

7.0/10 (57 reviews)
Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouriโ€”wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"Clean room, nice comfortable beds. It was very quiet and we felt very safe. The only drawback was the toilet was too low."
Judy 1-night trip
Posted 13 hours ago
Pear Tree Inn Cape Girardeau West
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent
"Clean, good location, comfortable beds"
Elaine 1-night trip
Posted 14 hours ago
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"We've stayed here twice & each time the property is well maintained, clean & the staff are very friendly. Would definitely recommend to anyone!"
Tracy 1-night trip
Posted 14 hours ago
Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

8/10 Good
"The room did not have an extra roll of toilet paper and also the hairdryer did not work. That was the only two things that was not. I was not happy with."
Cabrina 1-night trip
Posted 1 day ago
Days Inn and Suites by Wyndham Sikeston
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Great experience- food, cleanliness, friendly staff"
Patti 1-night trip
Posted 2 days ago
Drury Plaza Hotel Cape Girardeau Conference Center
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"This was the perfect stress free getaway. 10 minutes from a gas station and some fast food. 20 minutes from at least 2 cute towns and 3 wineries. It felt quiet without feeling isolated. The cabin was perfectly appointed with everything we needed, including firewood, starters, and lighters. We hope to go back!"
Lisa 2-night trip
Posted 3 days ago
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"Excellent breakfast,friendly staff and clean rooms"
Serapia 1-night trip
Posted 3 days ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

8/10 Good
"Clean and nice. Late check in but staff was very helpful and quick. Bedding was nice, mattress was more firm than I like but not uncomfortable."
Amanda 1-night trip
Posted 4 days ago
Holiday Inn Express & Suites Perryville by IHG
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

10/10 Excellent
"The receptionist was very courteous. Helped answer all my questions. We loved the room. And we had a great breakfast before we left."
David 1-night trip
Posted 6 days ago
Fairfield Inn & Suites by Marriott Cape Girardeau

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
RM234
RM255 total
28 Sept - 29 Sept
includes taxes & fees
Baymont Inn and Suites by Wyndham Farmington, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
RM270
RM308 total
17 Sept - 18 Sept
includes taxes & fees
7.2/10 Good! (1,002 reviews)
Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO
RM293
RM331 total
27 Sept - 28 Sept
includes taxes & fees
9.2/10 Wonderful! (1,007 reviews)
Pear Tree Inn Cape Girardeau West
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO
RM313
RM366 total
11 Oct - 12 Oct
includes taxes & fees
7.8/10 Good! (1,005 reviews)
Comfort Inn Festus - St Louis South
The Farmstead Hotel

The Farmstead Hotel

778 E 3rd St Caruthersville MO
RM387
RM440 total
5 Oct - 6 Oct
includes taxes & fees
The Farmstead Hotel
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO
RM411
RM468 total
20 Sept - 21 Sept
includes taxes & fees
9.4/10 Exceptional! (1,002 reviews)
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

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