Photo by Bill Dillard

Southeast Missouri hotels from RM249

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3 Dec - 4 Dec
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4 Dec - 5 Dec
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5 Dec - 7 Dec
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12 Dec - 14 Dec

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Top 10 trending Southeast Missouri hotels

Front of property
The Farmstead Hotel

The Farmstead Hotel

2.5 star property
Caruthersville
8.8 out of 10, Excellent, (460)
"Clean rooms and really comfortable beds!"
United States
Andrea
The price is RM353
RM401 total
includes taxes & fees
28 Dec - 29 Dec
The Farmstead Hotel
Exterior
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
Perryville
9.2 out of 10, Wonderful, (536)
"Clean room and pleasant staff"
United States
David
The price is RM360
RM413 total
includes taxes & fees
7 Dec - 8 Dec
Holiday Inn Express & Suites Perryville by IHG
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3.0 star property
Jackson
9.6 out of 10, Exceptional, (1013)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is RM342
RM362 total
includes taxes & fees
1 Jan - 2 Jan 2026
Drury Inn & Suites Jackson MO
Meeting facility
Baymont by Wyndham Festus

Baymont by Wyndham Festus

3.0 star property
Festus
6.8 out of 10, (918)
"Room was clean and comfortable for an overnight stay"
United States
Jack
The price is RM316
RM361 total
includes taxes & fees
8 Dec - 9 Dec
Baymont by Wyndham Festus
Lobby
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
"Great stay"
United States
Heather
The price is RM289
RM326 total
includes taxes & fees
8 Dec - 9 Dec
Pear Tree Inn Cape Girardeau West
Exterior
Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington

2.0 star property
Farmington
8.0 out of 10, Very good, (610)
"Clean, friendly staff, quiet"
United States
Stacy
The price is RM228
RM260 total
includes taxes & fees
4 Dec - 5 Dec
Super 8 by Wyndham Farmington
Lobby
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3.0 star property
Hayti
9.4 out of 10, Exceptional, (1007)
"Great stay. Clean room, and Drury Inns always seem to have the most comfortable beds."
United States
Ted
The price is RM388
RM443 total
includes taxes & fees
13 Dec - 14 Dec
Drury Inn & Suites Hayti Caruthersville
Free buffet breakfast
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

2.5 star property
Festus
9.4 out of 10, Exceptional, (698)
"Great place to stay!"
United States
Tracy
The price is RM492
RM562 total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Breakfast, lunch, dinner served; Italian cuisine
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (695)
"Amazing place"
United States
Mladen
The price is RM410
RM463 total
includes taxes & fees
7 Dec - 8 Dec
Holiday Inn Poplar Bluff by IHG
Exterior
Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville

2.0 star property
Perryville
8.4 out of 10, Very good, (935)
"The room was spotless, and the staff was extremely patient. Each one was very helpful. It was easy to get a good night's sleep - the building was very quiet."
United States
Cynthia
The price is RM260
RM298 total
includes taxes & fees
22 Dec - 23 Dec
Super 8 by Wyndham Perryville
In-room safe, desk, blackout curtains, iron/ironing board
Super 8 by Wyndham Potosi

Super 8 by Wyndham Potosi

2.0 star property
Potosi
7.0 out of 10, Good, (378)
"The room was very good for the price."
United States
Benjamin
The price is RM228
RM249 total
includes taxes & fees
4 Dec - 5 Dec
Super 8 by Wyndham Potosi
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 star property
Sikeston
9.0 out of 10, Wonderful, (437)
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
The price is RM393
RM445 total
includes taxes & fees
14 Dec - 15 Dec
Hampton Inn Sikeston
Front of property
Echo Bluff State Park

Echo Bluff State Park

2.5 star property
Eminence
9.6 out of 10, Exceptional, (216)
"Beautiful location…excellent service and facilities / grounds were clean and well kept."
United States
William
The price is RM657
RM695 total
includes taxes & fees
4 Dec - 5 Dec
Echo Bluff State Park
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
Jackson
8.8 out of 10, Excellent, (658)
"Great place "
United States
GUY
The price is RM347
RM376 total
includes taxes & fees
4 Dec - 5 Dec
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1009)
"I liked how comfortable the beds and pillows were."
United States
Christine
The price is RM289
RM326 total
includes taxes & fees
7 Dec - 8 Dec
Pear Tree Inn Cape Girardeau Near the Medical Center
Business centre
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property
Farmington
8.0 out of 10, Very good, (1002)
"Room was clean and big. Breakfast was awesome!"
United States
Ashley
The price is RM224
RM255 total
includes taxes & fees
31 Dec - 1 Jan 2026
Baymont Inn and Suites by Wyndham Farmington, MO
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1000)
"Great place and staff, very accommodating!"
United States
Megan
The price is RM371
RM419 total
includes taxes & fees
15 Dec - 16 Dec
Drury Plaza Hotel Cape Girardeau Conference Center
Business centre
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1008)
"I do love this hotel chain. Another great visit!"
United States
Mark
The price is RM371
RM419 total
includes taxes & fees
7 Dec - 8 Dec
Drury Inn & Suites Cape Girardeau
Lobby sitting area
The Riverview

The Riverview

4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (464)
"Place was nice and safe"
United States
ryan
The price is RM397
RM448 total
includes taxes & fees
4 Dec - 5 Dec
The Riverview
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Showing deals for:12 Dec - 14 Dec

Image gallery for Fairfield Inn & Suites by Marriott Cape Girardeau

Lobby

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
Cape Girardeau
9.4/10Exceptional (138 reviews)
15% off
Price is RM435
RM981 total
includes taxes & fees
Fairfield Inn & Suites by Marriott Cape Girardeau
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Stay near popular Central United States attractions

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
See properties
A huge granite boulder located in Elephant Rocks State Park
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

4.8/5 (52 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to Walnut Hollow Lake.

See all hotels in Southeast Missouri
Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"The room was clean, the staff were friendly, and they gave out free cookies in the evening, not just breakfast in the morning."
Erik 1-night trip
Posted 2 days ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
The price is RM224 per night from 31 Dec to 1 Jan
RM224
RM255 total
31 Dec - 1 Jan 2026
includes taxes & fees
8/10 Very Good! (1,005 reviews)

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