Photo by Bill Dillard
Southeast Missouri Business Hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Southeast Missouri Business Hotels
Our top choices for Southeast Missouri business-friendly hotels
9.4 out of 10, Exceptional, (224 reviews)
"This entire trip was inspired by Tina, a staff member. I met Tina passing through the area and she provided me with a lot of information which gave me the idea to plan a weekend trip with my wife. The lodge room we had was clean and comfortable, My wife and I had a wonderful time exploring most of the areas Tina mentioned. Thank you Tina for a wonderful inspiration for a get away. "
Jared
The price is RM639
RM675 total
includes taxes & fees
26 Feb - 27 Feb
9.6 out of 10, Exceptional, (1,012 reviews)
"Suited our purpose for overnight on a road trip "
Angela
The price is RM311
RM329 total
includes taxes & fees
9 Mar - 10 Mar
9.0 out of 10, Wonderful, (587 reviews)
"Very nice stay. The front desk lady named Tracy was terrific!"
Kevin
The price is RM360
RM410 total
includes taxes & fees
4 Mar - 5 Mar
Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (561 reviews)
"Staff was friendly and the place is clean. Our stay was in late January and the air was so very dry and the static electricity from blankets & sheets was off the charts."
Roger
The price is RM386
RM442 total
includes taxes & fees
15 Mar - 16 Mar
9.4 out of 10, Exceptional, (511 reviews)
"The room was clean and I was able to check in a bit early."
Sara
The price is RM375
RM423 total
includes taxes & fees
1 Mar - 2 Mar
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (159 reviews)
"Great hotel - super clean, fast check-in, convenient, etc.
We’ll definitely stay here again. "
Richard
The price is RM362
RM408 total
includes taxes & fees
5 Mar - 6 Mar
9.2 out of 10, Wonderful, (996 reviews)
"Great location and room "
Curtis
The price is RM366
RM413 total
includes taxes & fees
1 Mar - 2 Mar
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (710 reviews)
"Conveniently located, clean, friendly staff."
Philip
The price is RM327
RM354 total
includes taxes & fees
1 Mar - 2 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southeast Missouri Hotel Reviews
Drury Inn & Suites Cape Girardeau
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
- Belleview Hotels
- Bernie Hotels
- Black Hotels
- Bloomsdale Hotels
- Bunker Hotels
- Caravan Parks in Butler County
- Hotels with smoking rooms in Cape Girardeau
- Caravan Parks in Carter County
- De Soto Hotels
- Desloge Hotels
- Budget Hotels in Cape Girardeau County
- Pet friendly Hotels in Cape Girardeau County
- Lesterville Hotels
- Park Hills Hotels
- Qulin Hotels
- Caravan Parks in Ripley County
- Independent Hotels in Sikeston
- Sikeston Hotels
- B&B in Ste. Genevieve County
- Ste Genevieve Hotels
- Lodges in Washington County
- Flights to Bernie
- Flights from New Offenburg
- Flights from Qulin
- Flights from Tiff
- Flights from Accra (ACC) to Cape Girardeau (CGI)
- Flights from Alpine (ALE) to Cape Girardeau (CGI)
- Flights from Dallas (DFW) to Poplar Bluff (POF)
- Flights from Doha (DOH) to Cape Girardeau (CGI)
- Flights from Hagerstown (HGR) to Cape Girardeau (CGI)
- Flights from Wilmington (ILM) to Cape Girardeau (CGI)
- Flights from Kuala Lumpur (KUL) to Cape Girardeau (CGI)
- Flights from Columbus (LCK) to Cape Girardeau (CGI)
- Flights from Kansas City (MCI) to Cape Girardeau (CGI)
- Flights from Port of Spain (POS) to Cape Girardeau (CGI)
- Flights from San Antonio (SAT) to Poplar Bluff (POF)
- Flights from Valdosta (VLD) to Cape Girardeau (CGI)