Hotels in South Central Houston, Houston

Start date: Check-in selected.
To Date
End date: Check-out

    Change your mind

    Book hotels with free cancellation

    Treat yourself

    Sign in to save 10% or more on thousands of hotels

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Top 10 Hotels in South Central Houston, Houston

Hilton Houston Plaza/Medical Center
4.5 star property
8.4 out of 10, Very good, (1645)
"Amazing stay "
United States
JeVandon
The price is RM429
RM506 total
includes taxes & fees
16 Nov - 17 Nov
Hilton Houston Plaza/Medical Center
InterContinental Houston by IHG
4.0 star property
9.2 out of 10, Wonderful, (1015)
"I love this property everytime i stay here"
United States
Rukmi
The price is RM672
RM871 total
includes taxes & fees
16 Nov - 17 Nov
InterContinental Houston by IHG
Downtowner Inns - Houston Downtown
2.0 star property
8.2 out of 10, Very good, (10)
"Clean room"
United States
Merissa
The price is RM361
RM423 total
includes taxes & fees
20 Oct - 21 Oct
Downtowner Inns - Houston Downtown
Hotel Zaza Houston Museum District
4.5 star property
9.0 out of 10, Wonderful, (1800)
"Best place I have stayed in decades."
United States
Preston
Hotel Zaza Houston Museum District
DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
8.4 out of 10, Very good, (437)
"The hotel was a nice place for my family in a very difficult time."
United States
Sandi
The price is RM630
RM737 total
includes taxes & fees
20 Oct - 21 Oct
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Americas Best Value Inn Medical Center Downtown
2.0 star property
8.0 out of 10, Very good, (1009)
"Friendly staff"
United States
Somaya
The price is RM351
RM410 total
includes taxes & fees
20 Oct - 21 Oct
Americas Best Value Inn Medical Center Downtown
The Westin Houston Medical Center/Museum District
4.0 star property
9.0 out of 10, Wonderful, (1013)
"Great place to stay. "
United States
Keenan
The price is RM671
RM835 total
includes taxes & fees
26 Oct - 27 Oct
The Westin Houston Medical Center/Museum District
Houston Marriott Medical Center/Museum District
4.0 star property
9.0 out of 10, Wonderful, (1005)
"Property was very clean and safe was very friendly."
United States
Carolyn
The price is RM795
RM1,061 total
includes taxes & fees
2 Nov - 3 Nov
Houston Marriott Medical Center/Museum District
Wanderstay Houston Hostel
2.0 star property
8.2 out of 10, Very good, (185)
"This is an amazing place to stay."
United States
Darius
The price is RM254
RM297 total
includes taxes & fees
21 Oct - 22 Oct
Wanderstay Houston Hostel
Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
5.8 out of 10, (1010)
"the place if very clean, beds are comfortable, A/C works great and quiet and the staff (Maria, Sasha) were great people. I would definitely recommend staying here again. "
United States
juan
The price is RM316
RM371 total
includes taxes & fees
20 Oct - 21 Oct
Extended Stay America Suites Houston Med Ctr Braeswood Bl
La Maison in Midtown an urban B&B
3.5 star property
9.8 out of 10, Exceptional, (523)
"Breakfast delicious Customer service excellent"
United States
Emily
The price is RM756
RM885 total
includes taxes & fees
26 Oct - 27 Oct
La Maison in Midtown an urban B&B
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
9.6 out of 10, Exceptional, (193)
"I absolutely loved my stay here!!"
United States
Daniella
The price is RM875
RM1,087 total
includes taxes & fees
20 Oct - 21 Oct
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
Wanderstay Boutique Hotel
2.0 star property
10.0 out of 10, Exceptional, (51)
"Great Stay and the Staff was wonderful"
United States
Mark
The price is RM548
RM641 total
includes taxes & fees
2 Nov - 3 Nov
Wanderstay Boutique Hotel
Hilton University of Houston
3.5 star property
8.8 out of 10, Excellent, (870)
"Nice place to stay"
United States
Alexandra
The price is RM655
RM766 total
includes taxes & fees
25 Oct - 26 Oct
Hilton University of Houston
Spacious Houston 3bed3 Bath Family Townhome
2.0 star property
9.0 out of 10, Wonderful, (2)
"This rental was beautiful very clean and spacious. The location is very convenient if you are visiting the downtown area and for local shopping. The host was prompt with communicating when needed. It is a three story rental so the only issue was how tiring the stairs could be since the elevator was not available to use. I would definitely recommend and book with this host and rental property again. "
United States
Candance
The price is RM552
RM1,607 total
includes taxes & fees
23 Oct - 24 Oct
Spacious Houston 3bed3 Bath Family Townhome
Rodeway Inn & Suites Houston near Medical Center
2.0 star property
6.0 out of 10, (495)
"Very economical. Great price for one night stay."
United States
AUGUSTIN
The price is RM224
RM263 total
includes taxes & fees
31 Oct - 1 Nov
Rodeway Inn & Suites Houston near Medical Center
Southmore Boulevard Motel
2.0 star property
5.4 out of 10, (222)
"A classical Motel like in a Movie. The staff was really kind and helpful."
United Kingdom
Lisa-Maria
The price is RM228
RM267 total
includes taxes & fees
20 Oct - 21 Oct
Southmore Boulevard Motel
Luxurious 3 Bed3 Bath Near Downtown Houston
2.0 star property
10.0 out of 10, Exceptional, (1)
"This was made for a perfect family vacation… super clean kid friendly with an awesome view of Houston for the adults on rooftop "
United States
Ebony
The price is RM466
RM1,507 total
includes taxes & fees
3 Nov - 4 Nov
Luxurious 3 Bed3 Bath Near Downtown Houston
Newly Built Modern 3 Bedroom Houston Home
2.0 star property
10.0 out of 10, Exceptional, (2)
"The pictures do not do this property justice. The three story home has 3 beautiful bedrooms, each with luxurious bathrooms. The main bedroom and the living room has a small patio and then there's a rooftop seating area that is an excellent spot for gazing at the Houston night skyline. The quiet area is gated off a not too busy street in a beautiful neighborhood. We did have a couple of issues upon our arrival but the hosts were on top of it and had it resolved the next day. They have great...
United States
robin
Newly Built Modern 3 Bedroom Houston Home
Modern Cozy Home with King Bed
3.5 star property
9.4 out of 10, Exceptional, (21)
"Very spacious and close to just about everything. The view is amazing too"
United States
Brenden
The price is RM570
RM1,470 total
includes taxes & fees
20 Oct - 21 Oct
Modern Cozy Home with King Bed
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Where to stay in South Central Houston

Find the best South Central Houston areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Main Street Square Station.

Top South Central Houston Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

What's it like in South Central Houston?
Travellers are sure to enjoy a stay in Houston's South Central Houston neighbourhood. Looking for sights you might find in a travel guide about South Central Houston? Consider a visit to Houston Zoo while you're in the neighbourhood.
What's the best accommodation in South Central Houston?
Based on Expedia customer reviews, Wanderstay Boutique Hotel is the highest ranked property in South Central Houston. This hotel offers free parking and free WiFi. Other top choices in the neighbourhood include La Maison in Midtown an urban B&B and MyCrib Houston Hostel.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1153 hotels and other accommodation options in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best deals available in South Central Houston.
What is there to do around this Houston neighbourhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden and Bagby Dog Park. Houston Zoo and Continental Club are some other stops worth a visit in the neighbourhood. Toyota Center and Daikin Park are some popular places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station or Ensemble/HCC Station.