Medical Center District

San Antonio

Photo by Linda Cronan
Photo by Linda Cronan

Popular places to visit

USAA Corporate Office Headquarters

USAA Corporate Office Headquarters is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Stroll along the riverfront or attend a sporting event in this family-friendly area.

USAA Corporate Office Headquarters

South Texas Medical Center

If South Texas Medical Center is what brings you to town, hopefully you'll have a chance to explore more of San Antonio.

South Texas Medical Center

University of Texas Health and Science Center at San Antonio

If University of Texas Health and Science Center at San Antonio is what brings you to town, hopefully you'll have a chance to explore more of San Antonio.

University of Texas Health and Science Center at San Antonio

University Hospital - University Health System

If University Hospital - University Health System is what brings you to town, hopefully you'll have a chance to explore more of San Antonio.

University Hospital - University Health System

CHRISTUS Santa Rosa Hospital - Medical Center

If CHRISTUS Santa Rosa Hospital - Medical Center is what brings you to town, hopefully you'll have a chance to explore more of San Antonio.

CHRISTUS Santa Rosa Hospital - Medical Center

Methodist Healthcare

If Methodist Healthcare is what brings you to town, hopefully you'll have a chance to explore more of San Antonio.

Methodist Healthcare

Things to do

San Antonio: San Antonio Zoo Any Day Ticket

San Antonio: San Antonio Zoo Any Day Ticket

RM124
per adult
94% of travellers recommend
San Antonio: San Antonio Zoo Any Day Ticket
SEA LIFE San Antonio

SEA LIFE San Antonio

RM105
per adult
78% of travellers recommend
SEA LIFE San Antonio
San Antonio Old Town Trolley Hop-on Hop-Off Tour

San Antonio Old Town Trolley Hop-on Hop-Off Tour

RM218
per adult
96% of travellers recommend
San Antonio Old Town Trolley Hop-on Hop-Off Tour
San Antonio: Witte Museum Admission Ticket

San Antonio: Witte Museum Admission Ticket

RM71
per adult
74% of travellers recommend
San Antonio: Witte Museum Admission Ticket
San Antonio: Discovery Tour at Natural Bridge Caverns

San Antonio: Discovery Tour at Natural Bridge Caverns

RM151
per adult
92% of travellers recommend
San Antonio: Discovery Tour at Natural Bridge Caverns
Hop on Board the Ghost Bus

The Haunted Ghost Bus Tour in San Antonio

RM223
per adult
94% of travellers recommend
The Haunted Ghost Bus Tour in San Antonio
See all activities in San Antonio

Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is RM374 per night from 15 Oct to 16 Oct
RM374
RM443 total
15 Oct - 16 Oct
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (2,992 reviews)
"This was my go to hotel since the many stays my husband had in the hospitals the past few years. Recently, however, it appears a change in clientele has made my solo stays a little uncomfortable. This property is also in need of a little update."

Reviewed on 8 Oct 2025

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410, San Antonio, TX
The price is RM376 per night from 13 Oct to 14 Oct
RM376
RM447 total
13 Oct - 14 Oct
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,006 reviews)
"Water in the pool was super cool. But it was a nice pool."

Reviewed on 5 Oct 2025

San Antonio Marriott Northwest Medical Center
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

2.5 out of 5
7203 Wurzbach Road, San Antonio, TX
The price is RM372 per night from 26 Oct to 27 Oct
RM372
RM434 total
26 Oct - 27 Oct
includes taxes & fees
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,007 reviews)
"Friendly helpful staff. Awesome experience!!"

Reviewed on 3 Oct 2025

Fairfield Inn & Suites by Marriott San Antonio Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr, San Antonio, TX
The price is RM376 per night from 22 Oct to 23 Oct
RM376
RM444 total
22 Oct - 23 Oct
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,002 reviews)
"Great front desk service, very clean and spacious room, would definitely book again."

Reviewed on 3 Oct 2025

Courtyard by Marriott Medical Center San Antonio
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St, San Antonio, TX
The price is RM535 per night from 30 Oct to 31 Oct
RM535
RM747 total
30 Oct - 31 Oct
includes taxes & fees
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the bar and the helpful ...
9.4/10 Exceptional! (2,035 reviews)
Beyond expectations
"From the fast and friendly valet crew to the helpful and welcoming desk clerks and mangers, this place is truly the best. The bar and restaurant provide beautiful meals, snacks, and drinks all day! I can’t wait to go back"

Reviewed on 10 Oct 2025

Hotel Valencia Riverwalk
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street, San Antonio, TX
The price is RM507 per night from 29 Oct to 30 Oct
RM507
RM599 total
29 Oct - 30 Oct
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.2/10 Wonderful! (3,833 reviews)
"Clean room, friendly staff, free drinks and breakfast."

Reviewed on 10 Oct 2025

Drury Plaza Hotel San Antonio Riverwalk
See all 4,660 properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

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Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Convocation Center are top sights worth seeing.

Northwest Side
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Midtown

Unique features of Midtown include the river views and bars. Make a stop by The DoSeum or San Antonio Zoo and Aquarium while you're exploring the area.

Midtown
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La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

La Cantera District
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Tobin Hill

Tobin Hill might not have many top sights, but Alamo and San Antonio Museum of Art are two attractions nearby that you can check out.

Tobin Hill
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Uptown

If you're spending some time in Uptown, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

Uptown
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Alamo Heights

You'll enjoy the museums and coffee shops in Alamo Heights. You might want to make time for a stop at San Antonio River or Toilet Seat Museum.

Alamo Heights

Medical Center District