Medical Center District

San Antonio

A cityscape with a prominent tower, a large body of water, and a sunset.
A canal with colorful umbrellas and trees along the banks.
A riverside café with colorful umbrellas and tables.
A tranquil waterway flanked by lush greenery and stone pathways.
A canal with a boat, surrounded by lush greenery and a stone bridge.

Stay near popular Medical Center District attractions

Things to do


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is RM363 per night from 10 Aug to 11 Aug
RM363
RM429 total
10 Aug - 11 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very good! (3,560 reviews)
"Great breakfast. Wonderful service at front desk."

Reviewed on 9 Aug 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
The price is RM364 per night from 15 Aug to 16 Aug
RM364
RM430 total
15 Aug - 16 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (1,003 reviews)
"Very expensive no amenities police were on site when I arrived and when I left I was leaving an abusive relationship and staff member was not sympathetic to my situation"

Reviewed on 7 Aug 2026

Courtyard by Marriott Medical Center San Antonio
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
Fully refundableReserve now, pay when you stay
The price is RM368 per night from 13 Aug to 14 Aug
RM368
RM435 total
13 Aug - 14 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,406 reviews)
"very nice! staff was so helpful, everything was clean!"

Reviewed on 8 Aug 2026

Drury Inn & Suites San Antonio Northwest Medical Center
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is RM429 per night from 8 Sept to 9 Sept
RM429
RM509 total
8 Sept - 9 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy room service, a 24-hour fitness centre and Wi-Fi (surcharge). Our guests praise the helpful staff ...
San Antonio Marriott Northwest Medical Center
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
The price is RM524 per night from 12 Aug to 13 Aug
RM524
RM619 total
12 Aug - 13 Aug
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and 2 hot tubs. Our guests praise the breakfast and the pool in their reviews. ...
9.4/10 Exceptional! (5,063 reviews)
"It being on the river"

Reviewed on 9 Aug 2026

Drury Plaza Hotel San Antonio Riverwalk
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3 out of 5
303 Blum Street San Antonio TX
The price is RM291 per night from 7 Sept to 8 Sept
RM291
RM425 total
7 Sept - 8 Sept
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, a fitness centre and parking (surcharge). Our guests praise the breakfast and the ...
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

Downtown San Antonio

A scenic riverfront great entertainment and top sights from Alamo to Alamodome – discover Downtown San Antonio, a destination also famous for its historic sites.

Uptown

If you're spending some time in Uptown, Alamo Quarry Market and San Antonio Zoo and Aquarium are top sights worth seeing.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Crystal Ice Palace are top sights worth seeing.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.



Medical Center District