Medical Center District

San Antonio

River walk in San Antonio
Tourists River Walk San Antonio Texas
Riverboat on the San Antonio River Walk, San Antonio, Texas, United States of America.
River walk in San Antonio
SanAntonio_SouthTexasMedicalCenter_6193120_01

Popular places to visit

Things to do


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is RM358 per night from 7 Jun to 8 Jun
RM358
RM423 total
7 Jun - 8 Jun
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (3,400 reviews)
"Breakfast was good. Housekeeping staff were good. That's about it. Ice machines out of order. Television in both rooms malfunctioned and one replaced with smaller unit. Second television lost connection three times and required reset of Internet connection. Everything about the hotel seemed old and ..."

Reviewed on 6 Jun 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is RM406 per night from 13 Jun to 14 Jun
RM406
RM482 total
13 Jun - 14 Jun
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy a free local area shuttle, room service and a 24-hour fitness centre. Our guests praise the helpful ...
8.6/10 Excellent! (1,072 reviews)
"Very good"

Reviewed on 1 Jun 2026

San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
The price is RM361 per night from 25 Jun to 26 Jun
RM361
RM427 total
25 Jun - 26 Jun
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,340 reviews)
"The breakfast was exceptional. It was a full buffet style hot breakfast with 3 different meats, eggs, waffles, potatoes, oatmeal, yogurt, juices, coffee & tea. The room was spacious and clean. The shower was a dream! I would revisit this hotel again in a heartbeat!"

Reviewed on 6 Jun 2026

Drury Inn & Suites San Antonio Northwest Medical Center
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
The price is RM604 per night from 7 Jun to 8 Jun
RM604
RM715 total
7 Jun - 8 Jun
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and 2 hot tubs. Our guests praise the breakfast and the pool in their reviews. ...
9.4/10 Exceptional! (4,725 reviews)
"The front desk staff, food and beverage staff, and housekeeping were all amazing! The bar/restaurant downstairs was absolutely amazing, food, drinks and desserts were great! The complimentary breakfast was great as well. Location was perfect, we didn’t have to get our vehicle out of valet until the ..."

Reviewed on 5 Jun 2026

Drury Plaza Hotel San Antonio Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
The price is RM357 per night from 7 Jun to 8 Jun
RM357
RM423 total
7 Jun - 8 Jun
includes taxes & fees
Stay at this family-friendly hotel in San Antonio. Enjoy free Wi-Fi, room service and a 24-hour fitness centre. Our guests praise the restaurant and the helpful ...
8/10 Very Good! (6,474 reviews)
"Online photos were deceiving. Hotel was outdated, very nasty, room smelled like mildew. Was given another room only to find the FRIDGE SITTING IN THE SHOWER! My son’s room also had a smell, last night of stay water starting dripping down in the bathroom and eventually the ceiling fell down. General ..."

Reviewed on 6 Jun 2026

Riverwalk Plaza
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
The price is RM496 per night from 7 Jul to 8 Jul
RM496
RM702 total
7 Jul - 8 Jul
includes taxes & fees
Stay at this luxury hotel in San Antonio. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the clean rooms in ...
9.4/10 Exceptional! (2,800 reviews)
"The hotel rooms were very clean and nice. The hotel restaurant was okay. Parking would have been nice. And a pool would have given it an excellent rating"

Reviewed on 5 Jun 2026

Hotel Valencia Riverwalk
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

Downtown San Antonio

A scenic riverfront great entertainment and top sights from San Antonio River to Alamo – discover Downtown San Antonio, a destination also famous for its historic sites.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Alamo Quarry Market are top sights worth seeing.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Stone Ridge Market and Shops at Hardy Oak while you're in town.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.



Medical Center District