A bench, a bicycle, and a lake surrounded by trees.

Four Star Hotels in Upstate South Carolina

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Upstate South Carolina 4 Star Hotels

Tonight
3 Sept - 4 Sept
Tomorrow
4 Sept - 5 Sept
This weekend
4 Sept - 6 Sept
Next weekend
11 Sept - 13 Sept

Our top choices for Upstate South Carolina 4-star hotels

A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
A bar with multiple shelves of liquor bottles and glasses hanging above.
A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.

1. Hotel Hartness

Hotel Hartness
Greenville
United States
Cornelius
RM616
RM831 total
includes taxes & fees
30 Sept - 1 Oct
Hotel Hartness
A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
A modern interior with a fireplace, plush seating, and a stone accent wall.
An outdoor dining area with multiple tables and chairs, large windows, and a view of greenery.
A modern interior with a stone fireplace, seating areas, and a unique ceiling design.

2. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
United States
David
RM1,416
RM1,604 total
includes taxes & fees
27 Sept - 28 Sept
Grand Bohemian Lodge Greenville, Autograph Collection
A hotel facade with arched windows, a fountain, and a sign for "The Westin."
A lobby with patterned flooring, a grand staircase, and elegant furniture.
A banquet hall with round tables, chandeliers, and ornate windows.
A grand lobby with a chandelier, multiple seating areas, and a checkered floor pattern.

3. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
United States
Andre
RM724
RM833 total
includes taxes & fees
13 Sept - 14 Sept
The Westin Poinsett Greenville
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.
A modern kitchen with granite countertops, double sinks, and a built-in dishwasher.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a bar area with white stools.
A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a granite countertop. There are three white bar stools and two pendant lights.

4. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
United States
Channell
RM509
RM577 total
includes taxes & fees
8 Sept - 9 Sept
Mint House Greenville Downtown by Kasa
A bar area with multiple hanging decorative lights, a counter with bar stools, and a seating area with chairs.
A banquet hall with round tables set for dining, large windows, and a stage with curtains.
A modern building with a large illuminated logo reading "TOPGOLF" on the facade.
A spacious indoor venue with rows of white chairs adorned with purple sashes, large windows, and a modern ceiling design.

5. Greenville Marriott

Greenville Marriott
Greenville
United States
John
RM481
RM545 total
includes taxes & fees
14 Sept - 15 Sept
Greenville Marriott
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.
An outdoor patio with wicker furniture, a round table, and a fountain.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.

6. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
RM967
RM1,073 total
includes taxes & fees
6 Sept - 7 Sept
The Shepherd Hotel Downtown Clemson
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.

7. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Robert
RM615
RM683 total
includes taxes & fees
7 Sept - 8 Sept
The Abernathy of Clemson
A white, two-story house with a front porch, surrounded by trees and shrubs.
A two-story building with a white exterior, a front door, and a balcony.
A dining area with round tables, black chairs, and white tablecloths.
A hallway with a wooden bench, a chair, a cabinet, and a painting on the wall.

8. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
Pendleton
United States
enrique
RM502
RM557 total
includes taxes & fees
5 Sept - 6 Sept
Liberty Hall Bed and Breakfast
A modern building with outdoor seating and a garden.
A modern living room with a sofa, coffee table, and dining table. There is a TV mounted on the wall, a coffee machine, and a bookshelf.
A modern kitchen with white cabinetry, a wooden dining table, and a black chair. There is a window with a view of greenery outside.
A row of modern, two-story buildings with a covered patio area.

9. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
United States
Anonymous traveller
RM916
RM1,340 total
includes taxes & fees
8 Sept - 9 Sept
The Station by Compo Hotels
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A bar with a large window view of mountains and a chandelier.
A swimming pool with lounge chairs and a building with balconies.
A restaurant with a stone fireplace, hanging crystal chandelier, and multiple dining tables set with white tablecloths and wine glasses.

10. Hotel Domestique

Hotel Domestique
Travelers Rest
United States
Chuck
RM1,493
RM1,642 total
includes taxes & fees
7 Sept - 8 Sept
Hotel Domestique
A spacious living room with a stone fireplace, wooden beams, and a chandelier.
A modern kitchen with dark cabinetry, a stainless steel range, and a granite countertop.
A multi-story residential building with balconies, a stone archway entrance, and a sign indicating it is part of Century Park at Taft Community.
A modern kitchen with dark wood cabinets, a black refrigerator, a microwave, and a stainless steel sink. There are two bar stools at the island, and a flat-screen TV mounted on the wall.

11. Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
Greer
United States
Amanda
Landing Apartments Greer - Sugar Creek
A wooden gazebo with a roof and a table and chairs inside, surrounded by trees and overlooking a lake.
A modern building with a prominent wooden entrance canopy, stone pillars, and a clear sky.
A spacious hotel lobby with a bar area, seating arrangements, and large windows offering views.
A modern living room with a sofa, a coffee table, and a fireplace.

12. Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
A wooden gazebo with a roof, surrounded by trees, overlooking a lake.
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A spacious living area with a high ceiling, wooden beams, a grey sofa, a brown leather chair, and a dining table with a plant.
A modern kitchen with stainless steel appliances, a granite countertop, and large windows offering a view of the outdoors.

13. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
Salem
United States
Anonymous traveller
Designer Retreat w/ Pool, Golf + Beach Access!
A swimming pool with a view of a lake and docked boats.
A wooden deck with a table and chairs, surrounded by trees.
A spacious living room with a grey sofa, a wooden coffee table, and a blue rug. There is a dining area with a wooden table and chairs.

14. Private Balcony: Lake Keowee Home w/ Pool Access

Private Balcony: Lake Keowee Home w/ Pool Access
Salem
Private Balcony: Lake Keowee Home w/ Pool Access
A bedroom with a bed, a chair, and a potted aloe plant on a table.
A modern living room with a flat-screen TV, two leather chairs, a wooden dining table, and a potted plant.
A modern kitchen with stainless steel appliances, dark wooden cabinets, a dining table with chairs, and a potted plant.
A modern kitchen with stainless steel appliances, a dining area with a table and chairs, and a TV mounted on a wooden cabinet.

15. Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, and a sink.
A marina with boats docked, a wooden pier, and a clear sky.
A multi-story hotel with a parking lot and a view of a lake.

16. Lake Keowee Condo w/ Balcony & Resort Amenities!

Lake Keowee Condo w/ Balcony & Resort Amenities!
Salem
Lake Keowee Condo w/ Balcony & Resort Amenities!
A swimming pool with a view of the lake and docked boats.
A modern kitchen with a central island, stainless steel appliances, wooden cabinets, and a window providing natural light.
A marina with boats docked, surrounded by greenery and trees.
A spacious living area with a high ceiling, a large window with a view of trees, a kitchen with a bar, and a comfortable seating area with a sofa and ottomans.

17. Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A sandy beach with a calm lake surrounded by trees.
An indoor swimming pool with clear lanes, a covered roof, and a bench area.
A multi-story hotel with a parking lot and a view of a lake.

18. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
Salem
Lake Keowee Condo: Resort Pools & Lake Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A swimming pool with a view of a lake and docked boats.
A marina with boats docked, surrounded by greenery and trees.
A spacious living room with a fireplace, a television, and a staircase leading to an upper level.

19. Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
Salem
Salem Vacation Rental w/ Lake Keowee Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A large indoor swimming pool with clear lanes, a covered roof, and seating areas along the sides.
A marina with boats docked, a lifeguard station, and a view of a lake surrounded by trees.
A sandy beach with a calm lake surrounded by trees.

20. Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
Salem
Views, Pools & Marina: Lake Keowee Condo!
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Frankie's Fun Park to Conestee Nature Preserve.

See all hotels in Upstate South Carolina
An aerial view of a park with a winding path, trees in autumn colors, and a bridge.
Photo by Visit Greenville, South Carolina

Top Upstate South Carolina Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

8/10 Good
"Nice property that is extremely well located relative to downtown Greenville. Staff and facilities were first rate but I found the decor slightly tacky."
Henry R 1-night trip
Posted 6 days ago
Grand Bohemian Lodge Greenville, Autograph Collection

Find out more about Upstate South Carolina

Take Your Pick of 4 Star Hotels in Upstate South Carolina

The get-go of any holiday starts with choosing a great spot. Upstate South Carolina has been a popular destination with guests because it offers so much to do and see. But, "location, location, location" applies to more than just what city where your plane lands. Now that you have a feel for the town, it's time you to get to know your new digs.

Accommodations as Picturesque as Upstate South Carolina

Search Expedia.com.sg for the right 4 Star Upstate South Carolina Hotel to suit your fancy. Plenty of these people wrote tips to help you select the accommodation that is the right fit for your holiday.You'll be more than glad to get back to your resort every night. Upstate South Carolina has dozens of good options in the 4-star hotel range that create the ideal getaway.

A stay at one of these lodgings ensure that whether you are just relaxing after a day of checking out Upstate South Carolina or you are ready to lie down for the night, you'll be as comfortable as possible. You won't go without a thing during your stay at one of these accommodations. Visitors have consistently given them high marks for their attentive service. It's no surprise that loads of guests recommend it.

Reserve a 4-Star Hotel in Upstate South Carolina Today!

Your trip to Upstate South Carolina should be one that you'll reminisce over for years to come, and booking a 4-star hotel will help create memories that are incredible. Make sure to make a reservation soon. With so few hotels, and plenty of people desiring to vacation in Upstate South Carolina, you may miss out on your perfect hotel.

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.
  • Search for the lowest price from RM545
What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodation generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.

Explore a world of travel with Expedia