South Carolina Midlands hotels from RM274
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in South Carolina Midlands
Apart hotel
Family friendly
Check prices for these dates
Our top choices for South Carolina Midlands hotels
Holiday Inn Express & Suites Latta by IHG
Holiday Inn Express & Suites Latta by IHGLatta
9.4 out of 10, Exceptional, (612 reviews)
"Clean , comfortable bed , good breakfast and right off the highway"
Diana
The price is RM448
RM488 total
includes taxes & fees
12 Jul - 13 Jul
Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott SanteeSantee
9.8 out of 10, Exceptional, (1,004 reviews)
"Nice hotel stay, excellent staff and accommodations."
Carl
The price is RM546
RM606 total
includes taxes & fees
14 Jul - 15 Jul
Hampton Inn & Suites Lexington Columbia
Hampton Inn & Suites Lexington ColumbiaLexington
9.8 out of 10, Exceptional, (672 reviews)
"Excellent place!"
Luis Ortiz
The price is RM504
RM560 total
includes taxes & fees
24 Jul - 25 Jul
Aiken Midtown Hotel
Aiken Midtown HotelAiken
8.6 out of 10, Excellent, (386 reviews)
"everything was great, the place was nice and clean and perfect located."
Evelio
The price is RM387
RM433 total
includes taxes & fees
19 Jul - 20 Jul
Carriage House Inn
Carriage House InnAiken
9.6 out of 10, Exceptional, (516 reviews)
"Stayed 3 nights really loved the breakfast, accommodations, and location."
Melissa
The price is RM446
RM499 total
includes taxes & fees
6 Jul - 7 Jul
Hampton Inn Santee-I-95
Hampton Inn Santee-I-95Santee
9.6 out of 10, Exceptional, (1,003 reviews)
"Nice breakfast, rooms spacious, convenient location"
Gloria
The price is RM515
RM572 total
includes taxes & fees
4 Aug - 5 Aug
Best Western Plus Santee Inn
Best Western Plus Santee InnSantee
8.8 out of 10, Excellent, (1,003 reviews)
"We loved our one night stay, it’s was quiet and warming."
Lisett
The price is RM456
RM506 total
includes taxes & fees
8 Jul - 9 Jul
Tru By Hilton Santee
Tru By Hilton SanteeSantee
9.2 out of 10, Wonderful, (871 reviews)
"The room was very clean and the staff were extremely friendly"
Jeffrey
The price is RM432
RM479 total
includes taxes & fees
19 Jul - 20 Jul
Springhill Suites by Marriott Columbia near Fort Jackson
Springhill Suites by Marriott Columbia near Fort JacksonColumbia
9.4 out of 10, Exceptional, (744 reviews)
"Friendly and respectful staff members, the rooms are clean and fresh, especially the bathroom. The beds are very comfortable and relaxing."
Sandra
The price is RM391
RM437 total
includes taxes & fees
19 Jul - 20 Jul
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHGFlorence
8.6 out of 10, Excellent, (1,000 reviews)
"Very clean. Good breakfast buffet. Safe place to stay."
Jeffrey
The price is RM566
RM650 total
includes taxes & fees
19 Jul - 20 Jul
Tru By Hilton Columbia Greystone
Tru By Hilton Columbia GreystoneColumbia
9.2 out of 10, Wonderful, (1,014 reviews)
"Great stay"
Monique
The price is RM408
RM465 total
includes taxes & fees
24 Jul - 25 Jul
Lexington Expo Hotel by IHG
Lexington Expo Hotel by IHGLexington
9.0 out of 10, Wonderful, (1,000 reviews)
"Great room with plenty of space and parking"
Matthew
The price is RM411
RM456 total
includes taxes & fees
19 Jul - 20 Jul
Hampton Inn & Suites Columbia Killian Road
Hampton Inn & Suites Columbia Killian RoadColumbia
9.2 out of 10, Wonderful, (1,071 reviews)
"Rooms were great, location was great and the breakfast was delicious!"
Tiffany
The price is RM472
RM529 total
includes taxes & fees
2 Aug - 3 Aug
Park Inn by Radisson Florence, SC
Park Inn by Radisson Florence, SCFlorence
9.0 out of 10, Wonderful, (2,316 reviews)
"Awesome stay."
Pierre
The price is RM363
RM406 total
includes taxes & fees
26 Jul - 27 Jul
Hampton Inn Newberry-Opera House
Hampton Inn Newberry-Opera HouseNewberry
8.8 out of 10, Excellent, (844 reviews)
"Hotel is starting to show its age and needs updating in the rooms. Staff is always very friendly and helpful and the hotel location is perfect. Great hotel for the price."
Randy
The price is RM444
RM493 total
includes taxes & fees
19 Jul - 20 Jul
TRU BY Hilton North Augusta
TRU BY Hilton North AugustaNorth Augusta
9.6 out of 10, Exceptional, (273 reviews)
"Nice and clean spot!"
April
The price is RM514
RM576 total
includes taxes & fees
4 Aug - 5 Aug
Best Western Plus Lexington Inn
Best Western Plus Lexington InnDowntown Lexington
9.2 out of 10, Wonderful, (1,002 reviews)
"First time staying and was impressed"
Dennis
The price is RM407
RM452 total
includes taxes & fees
12 Jul - 13 Jul
Comfort Inn & Suites Florence Center Area
Comfort Inn & Suites Florence Center AreaFlorence
9.0 out of 10, Wonderful, (1,315 reviews)
"Clean room and breakfast was great"
Dana
The price is RM475
RM532 total
includes taxes & fees
28 Jul - 29 Jul
Howard Johnson by Wyndham Florence
Howard Johnson by Wyndham FlorenceFlorence
8.6 out of 10, Excellent, (2,680 reviews)
"Friendly staff, great room and lovely grounds"
John
The price is RM275
RM308 total
includes taxes & fees
6 Jul - 7 Jul
Holiday Inn Express & Suites Newberry by IHG
Holiday Inn Express & Suites Newberry by IHGNewberry
9.0 out of 10, Wonderful, (700 reviews)
"Always a great stay, very clean and the breakfast is awesome."
Aubrey
The price is RM418
RM451 total
includes taxes & fees
20 Jul - 21 Jul
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in South Carolina Midlands
Holiday Home
9.2 out of 10, Wonderful, (24 reviews)
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular South Carolina Midlands attractions
Learn more about South Carolina Midlands
With Revolutionary War sites, a charming capital city and lots of kayaking opportunities, this southern region is sure to delight.
Top South Carolina Midlands Hotel Reviews
Quality Inn & Suites Florence Civic Center
10/10 Excellent
More cheap stays in South Carolina Midlands
Motel 6 Fort Mill, SC - Charlotte
3541 Foothills Way Fort Mill SC
The price is RM244 per night from 6 Jul to 7 Jul
RM244
RM279 total
6 Jul - 7 Jul
includes taxes & fees
6.4/10 (1,063 reviews)
4 Star Hotels
13 properties
Explore a world of travel with Expedia
- Bishopville Hotels
- Chapin Hotels
- Columbia Hotels
- Beach Resorts in South Carolina
- Gay friendly Hotels in South Carolina
- Hotels with Balcony in South Carolina
- Hotels with Spa in South Carolina
- South Carolina Hotels
- Downtown Columbia Hotels
- Hotels near Dreher Island State Park
- Elgin Hotels
- Fort Lawn Hotels
- Gaston Hotels
- Lancaster Hotels
- Lugoff Hotels
- Prosperity Hotels
- Richburg Hotels
- Cottages in Richland County
- Ridgeway Hotels
- Hotels near Shaw Air Force Base
- Caravan Parks in South Carolina
- Country Houses in South Carolina
- Lodges in South Carolina
- Resorts in South Carolina
- Villas in South Carolina
- Springdale Hotels
- Sumter Hotels
- West Columbia Hotels
- Flights to South Carolina
- Flights to Blythewood
- Flights to Columbia
- Flights to South Carolina Midlands
- Flights from South Carolina
- Flights from Elgin
- Flights from Columbia
- Flights from Allentown (ABE) to Columbia (CAE)
- Flights from Pittsburgh (AGC) to Columbia (CAE)
- Flights from Apartado (APO) to Columbia (CAE)
- Flights from Huaraz (ATA) to Columbia (CAE)
- Flights from Atlanta (ATL) to Columbia (CAE)
- Flights from Oranjestad (AUA) to Columbia (CAE)
- Flights from Alexandroupolis (AXD) to Columbia (CAE)
- Flights from Boca Raton (BCT) to Columbia (CAE)
- Flights from Bristol (BRS) to Columbia (CAE)
- Flights from Bou Saada (BUJ) to Columbia (CAE)
- Flights from Canberra (CBR) to Columbia (CAE)
- Flights from Paris (CDG) to Columbia (CAE)
- Flights from Dangriga (DGA) to Columbia (CAE)
- Flights from Durango (DRO) to Columbia (CAE)
- Flights from Dakar (DSS) to Columbia (CAE)
- Flights from Edinburgh (EDI) to Columbia (CAE)
- Flights from Eugene (EUG) to Columbia (CAE)
- Flights from Fort Lauderdale (FLL) to Columbia (CAE)
- Flights from Glasgow (GLA) to Columbia (CAE)
- Flights from Goiania (GYN) to Columbia (CAE)
- Flights from Hot Springs (HOT) to Columbia (CAE)
- Flights from Harare (HRE) to Columbia (CAE)
- Flights from Niagara Falls (IAG) to Columbia (CAE)
- Flights from Ibiza (IBZ) to Columbia (CAE)
- Flights from Ipoh (IPH) to Columbia (CAE)
- Flights from Kathmandu (KTM) to Columbia (CAE)
- Flights from Kuala Lumpur (KUL) to Columbia (CAE)
- Flights from Kwajalein (KWA) to Columbia (CAE)
- Flights from Los Angeles (LAX) to Columbia (CAE)
- Flights from New York (LGA) to Columbia (CAE)
- Flights from Lopez Island (LPS) to Columbia (CAE)
- Flights from Luoyang (LYA) to Columbia (CAE)
- Flights from Manchester (MAN) to Columbia (CAE)
- Flights from Orlando (MCO) to Columbia (CAE)
- Flights from Mexico City (MEX) to Columbia (CAE)
- Flights from Kayenta (MVM) to Columbia (CAE)
- Flights from Osh (OSS) to Columbia (CAE)
- Flights from Piedras Negras (PDS) to Columbia (CAE)
- Flights from Polokwane (PTG) to Columbia (CAE)
- Flights from Rajahmundry (RJA) to Columbia (CAE)
- Flights from Reno (RNO) to Columbia (CAE)
- Flights from Sacramento (SAC) to Columbia (CAE)
- Flights from San Diego (SAN) to Columbia (CAE)
- Flights from Louisville (SDF) to Columbia (CAE)
- Flights from Singapore (SIN) to Columbia (CAE)
- Flights from Split (SPU) to Columbia (CAE)
- Flights from St. Cloud (STC) to Columbia (CAE)
- Flights from Moscow (SVO) to Columbia (CAE)
- Flights from Daegu (TAE) to Columbia (CAE)
- Flights from Kangiqsualujjuaq (XGR) to Columbia (CAE)
- Flights from Grande Prairie (YQU) to Columbia (CAE)
- Columbia Canal and Riverfront Park
- Columbia Holidays
- Eau Claire Holidays
- Hampton-Preston Mansion and Gardens
- Harbison State Forest
- Hilton Field
- Visit Irmo
- Mann-Simons Cottage
- Palmetto Health Richland Hospital
- Sesquicentennial State Park
- South Carolina Holidays
- Visit South Carolina
- Village at Sandhill Mall
