Top 10 Hotels Near Mayo Clinic in Rochester for 2026

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Our top choices for Mayo Clinic hotels

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

A modern restaurant with a counter, seating area, and a TV screen.

A modern lounge area with a sofa, chairs, and tables.

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

2.6 km from Mayo Clinic

Vickie

RM498

RM573 total

includes taxes & fees

24 Oct - 25 Oct

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

2. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park, 1.8 km from Mayo Clinic

Jon

RM491

RM566 total

includes taxes & fees

8 Oct - 9 Oct

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

A modern pool table in a spacious, well-lit room with large windows and a bar area.

A modern interior with a large dining table, sofas, and a kitchen area.

3. The Berkman

Folwell, 1.4 km from Mayo Clinic

Suzette

RM733

RM853 total

includes taxes & fees

2 Oct - 3 Oct

A coffee shop interior with a wooden counter, menu boards, and seating area.

An outdoor seating area with tables and chairs, a neon sign, and flower arrangements.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

4. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 0.4 km from Mayo Clinic

Hafsa

RM558

RM643 total

includes taxes & fees

2 Oct - 3 Oct

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern hotel with a flat roof, multiple windows, and a covered outdoor seating area.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

A modern lounge area with seating, a fireplace, and a bar area.

5. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.4 km from Mayo Clinic

Chee

RM562

RM647 total

includes taxes & fees

11 Oct - 12 Oct

A modern living room with a flat-screen TV, a fireplace, comfortable seating, and a large window with a city view.

A modern hotel entrance with a glass facade, illuminated signage, and a covered walkway.

A modern hotel lobby with a curved staircase, seating areas, and large windows.

A spacious lobby with modern furniture, a spiral staircase, and large windows offering views of the outdoors.

6. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 0.3 km from Mayo Clinic

Raymond

RM732

RM842 total

includes taxes & fees

17 Oct - 18 Oct

A modern indoor patio with a fire feature, seating, and large windows.

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

A reception area with a curved reception desk, wooden shelving, and a green moss wall with the text "I ♥ EVEN".

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

Brooke

RM497

RM627 total

includes taxes & fees

2 Oct - 3 Oct

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A hotel room with a kitchenette, a bed, a sofa, a small table, and a window with curtains.

A gym with various exercise equipment, including treadmills, stationary bikes, and weight machines.

A modern kitchen with a central island, bar stools, and pendant lighting. A living area with a sofa, ottoman, and a view of the outdoors is visible.

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 1 km from Mayo Clinic

Sheri

RM436

RM510 total

includes taxes & fees

25 Oct - 26 Oct

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

Two armchairs with striped pillows, a small round table, a clock, and a phone on a counter.

A hotel lobby with a reception desk, seating area, and a large window.

A hotel room with a large round table, two sofas, a TV, and a bed.

9. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.6 km from Mayo Clinic

Sean

RM473

RM544 total

includes taxes & fees

2 Oct - 3 Oct

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

An indoor swimming pool with clear pool rules posted on the wall, a lifeguard chair, and a pool lift sign.

A modern hotel lobby with a stone wall fireplace, comfortable seating, and a chandelier.

A gym with exercise equipment, a clock, and a window with blinds.

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

Lin

RM464

RM535 total

includes taxes & fees

24 Oct - 25 Oct

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A hotel room with a bed, a sofa, a desk, a TV, and a wall art piece.

A modern living room with a sofa, a round coffee table, and a side table. There are large windows with a view of the outside.

A hotel room with a sofa, armchairs, a small kitchenette, a flat-screen TV, and a large window.

11. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 1.4 km from Mayo Clinic

MATTHEW

RM499

RM575 total

includes taxes & fees

2 Oct - 3 Oct

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern bar area with seating and a counter.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

12. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 0.5 km from Mayo Clinic

Kathy

RM481

RM553 total

includes taxes & fees

17 Oct - 18 Oct

A self-service breakfast station with a waffle maker, coffee machines, and a variety of condiments.

A reception area with a wooden reception desk, a red doormat, and framed awards on the wall.

A compact laundry area with a washing machine, dryer, and a water fountain.

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

13. Econo Lodge Mayo Clinic Area

3.1 km from Mayo Clinic

Ashley

RM287

RM331 total

includes taxes & fees

25 Oct - 26 Oct

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A pool area with a table and chairs, a lifeguard chair, and a pool lift.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

14. Hampton Inn Rochester-South

2.9 km from Mayo Clinic

dennis

RM431

RM496 total

includes taxes & fees

4 Oct - 5 Oct

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

A spa area with a hot tub, exercise equipment, and a seating area with chairs and a table.

An outdoor patio area with brick walls, a large arched window, and outdoor seating.

A hotel room with a kitchenette, a dining area with striped chairs, a sofa, a TV, and a window with curtains.

15. Aspen Suites

1.2 km from Mayo Clinic

Dana

RM578

RM698 total

includes taxes & fees

2 Oct - 3 Oct

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A long, narrow hotel corridor with a carpeted floor, light fixtures along the walls, and a ceiling with recessed lighting.

A paved garden area with two benches, a potted plant with yellow flowers, and a variety of greenery.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

16. Brentwood Inn & Suites

Downtown Rochester, 0.3 km from Mayo Clinic

Daniel

RM382

RM440 total

includes taxes & fees

2 Oct - 3 Oct

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

A compact kitchen with a microwave, refrigerator, and coffee maker. A small bar stool is near the counter.

17. Quality Inn & Suites Mayo Clinic Area

2.6 km from Mayo Clinic

Edward

RM312

RM363 total

includes taxes & fees

18 Oct - 19 Oct

A spacious outdoor dining area with modern furniture and large windows offering views of the city.

A reception desk with a modern design, featuring a wooden panel and a wall adorned with framed botanical artwork.

A modern hotel room with a large bed, a sofa, a small table, a desk, and a wardrobe.

A modern interior with a wooden ceiling, a large black shelving unit, and a refrigerator stocked with beverages.

18. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 0.4 km from Mayo Clinic

thomas

RM436

RM502 total

includes taxes & fees

24 Oct - 25 Oct

An outdoor patio area with yellow umbrellas, wicker furniture, and a sign for Centerstone Plaza Hotel.

A garden with a water feature, rocks, and yellow umbrellas.

A modern reception area with a wooden reception desk, glass pendant lights, and a long hallway with seating.

A restaurant interior with wooden tables, chairs, and a stone wall.

19. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest, 0.6 km from Mayo Clinic

Carrie

RM439

RM506 total

includes taxes & fees

2 Oct - 3 Oct

A modern hotel lobby with multiple seating areas, including a central dining table with chairs, a bar area, and a seating section with cushioned chairs.

A modern lounge area with a curved sofa, a round table, and a seating area with chairs.

A modern hotel room with a large bed, two bedside tables, and built-in lighting.

A hotel reception desk with a modern design, a clock, and a digital screen.

20. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Kutzky Park, 1.1 km from Mayo Clinic

Jackie

RM473

RM545 total

includes taxes & fees

4 Oct - 5 Oct

View all properties

Compare popular hotels close to Mayo Clinic

Property	Property class	Guest rating
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,005 reviews	View
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.6 Exceptional 740 reviews	View
The Berkman	9.6 Exceptional 443 reviews	View
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6 Exceptional 562 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 311 reviews	View

Top Mayo Clinic Hotel Reviews

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent

"Returned patron while having appointments at Mayo. Clean and Convenient lodging with amnesties"

Hotel Indigo Rochester – Mayo Clinic Area by IHG

8/10 Good

"Rooms were very clean and easy to manage. find the hotel was difficult"

Hilton Garden Inn Rochester Downtown, MN

8/10 Good

"The beds were great! The staff very friendly. We stayed for just one night so didn't use many of the amenities. We were disappointed that there was a charge for breakfast...a simple continental breakfast was $12! Whereas the other hotels where we had stayed on previous visits to Rochester had free breakfast! They also had free parking whereas we had to pay for parking at a nearby parking ramp at this hotel."

Brentwood Inn & Suites

8/10 Good

"Walking distance to Mayo—very handy amidst construction."

Kahler Grand Hotel

10/10 Excellent

"Love the 40’s vibes that this modern hotel has."

AmericInn by Wyndham Rochester Near Mayo Clinic

8/10 Good

"Great price, my child enjoyed the pool area, room was comfortable, staff was great!"

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent

"Na"

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent

"We had a great night of sleep after a long day at Mayo. The bed was comfortable. Hotel was clean and staff was helpful and very friendly. The breakfast was good with many options."

Kahler Inn and Suites - Mayo Clinic Area

8/10 Good

"Staff at check in,close to mayo"

Frequently asked questions

What's the area like around Mayo Clinic?

Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, take a look at the 152 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Mayo Clinic?

Adjacent to Mayo Clinic, Kahler Grand Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers 2 restaurants and an indoor pool. Other good options close by include Kahler Inn and Suites - Mayo Clinic Area and Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area.

How many hotels should I expect to find near Mayo Clinic?

Expedia has 152 hotels and other accommodation options within a mile from Mayo Clinic.

If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?

Yes, most hotel bookings are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best deals near Mayo Clinic.

What can I see and do near Mayo Clinic?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Plummer House and Assisi Heights. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

Hotels near Mayo Clinic

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Our top choices for Mayo Clinic hotels

1. Home2 Suites by Hilton Rochester Mayo Clinic Area

2. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

3. The Berkman

4. TownePlace Suites by Marriott Rochester Mayo Clinic Area

5. Residence Inn by Marriott Rochester Mayo Clinic Area South

6. Hilton Rochester Mayo Clinic Area

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

9. Candlewood Suites Rochester Mayo Clinic Area by IHG

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

11. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

12. Hyatt House Rochester/Mayo Clinic Area

13. Econo Lodge Mayo Clinic Area

14. Hampton Inn Rochester-South

15. Aspen Suites

16. Brentwood Inn & Suites

17. Quality Inn & Suites Mayo Clinic Area

18. Hotel Indigo Rochester – Mayo Clinic Area by IHG

19. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

20. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Compare popular hotels close to Mayo Clinic

Top Mayo Clinic Hotel Reviews

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hilton Garden Inn Rochester Downtown, MN

Brentwood Inn & Suites

Kahler Grand Hotel

AmericInn by Wyndham Rochester Near Mayo Clinic

Hyatt House Rochester/Mayo Clinic Area

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Kahler Inn and Suites - Mayo Clinic Area

Frequently asked questions

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