Top 10 Hotels Near Mayo Clinic Hospital - Saint Marys Campus in Rochester for 2026

An aerial view of a campus with multiple buildings, parking lots, and surrounding greenery.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Mayo Clinic Hospital - Saint Marys Campus hotels

An outdoor patio area with a concrete floor, wooden fence, and string lights.

A breakfast bar with a wooden counter, a coffee machine, and a refrigerator.

A Fairfield Inn & Suites hotel with a modern design, featuring a prominent entrance and a parking area.

1. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park, 0.9 km from Mayo Clinic Hospital - Saint Marys Campus

Jon

RM451

RM519 total

includes taxes & fees

3 Sept - 4 Sept

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

A modern restaurant with a counter, seating area, and a TV screen.

A modern lounge area with a sofa, chairs, and tables.

An indoor swimming pool with wooden ceiling beams, yellow chairs, and tables along the sides.

2. Home2 Suites by Hilton Rochester Mayo Clinic Area

2.3 km from Mayo Clinic Hospital - Saint Marys Campus

Vickie

RM493

RM568 total

includes taxes & fees

4 Sept - 5 Sept

A modern living room with a flat-screen TV, a fireplace, comfortable seating, and a large window with a city view.

A modern hotel lobby with a curved staircase, seating areas, and large windows.

A modern hotel entrance with a glass facade, illuminated signage, and a covered walkway.

A modern indoor swimming pool with seating areas and a city view.

3. Hilton Rochester Mayo Clinic Area

Downtown Rochester, 1.7 km from Mayo Clinic Hospital - Saint Marys Campus

Jennifer

RM692

RM797 total

includes taxes & fees

4 Sept - 5 Sept

A coffee shop interior with a wooden counter, menu boards, and seating area.

An outdoor seating area with tables and chairs, a neon sign, and flower arrangements.

A hotel room with a bed, bedside table, and a window with curtains.

A hotel exterior with a 'Townplace Suites' sign, outdoor seating area, and 'OPEN' signage.

4. TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park, 1 km from Mayo Clinic Hospital - Saint Marys Campus

Jorge

RM513

RM590 total

includes taxes & fees

29 Aug - 30 Aug

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

A modern lounge area with seating, a fireplace, and a bar area.

A modern reception area with a brick-patterned wall, two reception desks, a flat-screen TV, and seating arrangements including a sofa and chairs.

An outdoor patio area with wicker furniture, a central fire feature, and a stone building in the background.

5. Residence Inn by Marriott Rochester Mayo Clinic Area South

2.3 km from Mayo Clinic Hospital - Saint Marys Campus

Richard

RM553

RM637 total

includes taxes & fees

4 Sept - 5 Sept

A spacious living area with a modern staircase, leather sofas, and contemporary lighting.

A rooftop pool area with lounge chairs and umbrellas, surrounded by a modern building with a brick facade.

An outdoor seating area with blue sofas and wicker chairs, a wooden table, and green ottomans on a tiled patio.

A modern pool table in a spacious, well-lit room with large windows and a bar area.

6. The Berkman

Folwell, 0.1 km from Mayo Clinic Hospital - Saint Marys Campus

William

RM827

RM961 total

includes taxes & fees

1 Sept - 2 Sept

A modern indoor patio with a fire feature, seating, and large windows.

A modern hotel lobby with a large glass wall, a green wall mural, and a seating area with sofas and chairs.

A modern interior with a seating area, a bookshelf, and a window with a view of trees.

A modern living room with a fireplace, large windows, and a flat-screen TV mounted on the wall.

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park, 0.4 km from Mayo Clinic Hospital - Saint Marys Campus

paul

RM408

RM524 total

includes taxes & fees

29 Aug - 30 Aug

A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

A hotel room with a kitchenette, a bed, a sofa, a small table, and a window with curtains.

A gym with various exercise equipment, including treadmills, stationary bikes, and weight machines.

A modern kitchen with a central island, bar stools, and pendant lighting. A living area with a sofa, ottoman, and a view of the outdoors is visible.

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park, 0.4 km from Mayo Clinic Hospital - Saint Marys Campus

Marissa

RM416

RM487 total

includes taxes & fees

5 Sept - 6 Sept

An indoor swimming pool with a glass ceiling, lounge chairs, and a neon sign for the hotel.

A hotel room with a desk, chair, sofa, and a small table.

A hotel room with a dining area featuring a round table and blue chairs, a kitchen area with a microwave and cabinets, and a large mirror above the sink.

A hotel entrance with a curved roof, a sign reading "The Hotel", and a Christmas tree in front.

9. The Towers At Kahler Grand Hotel

Downtown Rochester, 1.4 km from Mayo Clinic Hospital - Saint Marys Campus

Chris

RM1,450

RM1,670 total

includes taxes & fees

6 Sept - 7 Sept

An outdoor patio with a brick floor, stone fireplace, and wooden pergola.

An indoor swimming pool with clear pool rules posted on the wall, a lifeguard chair, and a pool lift sign.

A conference room with multiple tables and chairs, ceiling fans, and artwork on the walls.

A gym with exercise equipment, a clock, and a window with blinds.

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Kutzky Park, 0.2 km from Mayo Clinic Hospital - Saint Marys Campus

Lin

RM394

RM454 total

includes taxes & fees

4 Sept - 5 Sept

A Courtyard Marriott hotel with multiple floors, a brick facade, and illuminated signage.

A hotel room with a sofa, armchairs, a small kitchenette, a flat-screen TV, and a large window.

A hotel room with a bed, a sofa, a desk, a TV, and a wall art piece.

A conference room with a long table, multiple chairs, and decorative wall art.

11. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Kutzky Park, 0.2 km from Mayo Clinic Hospital - Saint Marys Campus

MATTHEW

RM418

RM481 total

includes taxes & fees

12 Sept - 13 Sept

A hotel with a stone facade, multiple windows, and a sign reading "CANDLEWOOD SUITES".

A hotel room with a large round table, two sofas, a TV, and a bed.

A hotel gym with treadmills, elliptical machines, and weight benches.

A modern kitchen with a dark countertop, black cabinets, a microwave, and a refrigerator. There are two pendant lights above the counter.

12. Candlewood Suites Rochester Mayo Clinic Area by IHG

2.9 km from Mayo Clinic Hospital - Saint Marys Campus

Sean

RM468

RM539 total

includes taxes & fees

28 Aug - 29 Aug

A bedroom with a large bed, a TV on a dresser, and a view of the city through large windows.

A multi-story building with the sign 'Broadway Plaza' indicating a commercial or hotel property.

A modern kitchen with wooden cabinets, a granite countertop, and a stainless steel stove.

13. Broadway Plaza, Trademark Collection by Wyndham

Downtown Rochester, 1.7 km from Mayo Clinic Hospital - Saint Marys Campus

Camille

RM683

RM786 total

includes taxes & fees

4 Sept - 5 Sept

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

A coffee station with four coffee dispensers, a stack of disposable cups, and a tray with various coffee-related items.

A modern lounge area with seating arrangements, a reception desk, and a patterned wall.

A hotel room with a bed, a desk, a chair, a TV, and a bathroom visible through an open door.

14. Hampton Inn Rochester-South

3.1 km from Mayo Clinic Hospital - Saint Marys Campus

Lynne

RM381

RM438 total

includes taxes & fees

30 Aug - 31 Aug

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern bar area with seating and a counter.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

A modern indoor pool area with lounge chairs and a pool.

15. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester, 1.6 km from Mayo Clinic Hospital - Saint Marys Campus

Bridgett

RM582

RM670 total

includes taxes & fees

18 Sept - 19 Sept

A hotel entrance with a stone facade, a glass door, and a metal roof structure.

A spa area with a hot tub, exercise equipment, and a seating area with chairs and a table.

A hotel lobby with striped armchairs, a sofa, a fireplace, and a clock on the wall.

An outdoor patio area with brick walls, a large arched window, and outdoor seating.

16. Aspen Suites

0.2 km from Mayo Clinic Hospital - Saint Marys Campus

CASEY

RM572

RM692 total

includes taxes & fees

29 Aug - 30 Aug

A room with a fireplace, two leather armchairs, a sofa, and a large window providing a view of the outdoors.

A hotel room with a bed, a sink, a microwave, and a window with curtains.

A paved garden area with two benches, a potted plant with yellow flowers, and a variety of greenery.

A reception area with a curved counter, ceiling lights, and a potted plant.

17. Brentwood Inn & Suites

Downtown Rochester, 1.3 km from Mayo Clinic Hospital - Saint Marys Campus

Bryan

RM505

RM581 total

includes taxes & fees

26 Aug - 27 Aug

A modern lobby with a reception desk, a green sofa, and a black spherical table.

An outdoor dining area with wooden beams, tables, and chairs.

A modern hotel with a prominent 'Hotel Indigo' sign, a 'Crave Drink' restaurant, and a well-lit facade.

A modern bar area with a central island, bar stools, and hanging spherical light fixtures.

18. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester, 1.7 km from Mayo Clinic Hospital - Saint Marys Campus

Kyle

RM376

RM432 total

includes taxes & fees

12 Sept - 13 Sept

A spacious hotel lobby with multiple seating areas, including sofas and round tables, and a large dining area with yellow chairs.

A spacious lobby with a large seating area, a fireplace, and large windows providing natural light.

A grocery store with refrigerated and frozen sections, shelves stocked with snacks, and a variety of beverages.

A reception area with two counters, a patterned wall, and a wooden floor.

19. Hilton Garden Inn Rochester Downtown, MN

Downtown Rochester, 1.6 km from Mayo Clinic Hospital - Saint Marys Campus

Eileen

RM460

RM530 total

includes taxes & fees

5 Sept - 6 Sept

A hotel breakfast area with a self-serve station, including a waffle maker, toaster, and various food items.

A hotel lobby with a patterned carpet, two beige armchairs, a small table, a clock, a fire extinguisher, and a staircase.

A hotel room with a large bed, bedside tables, a mirror, and a patterned carpet.

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

20. Quality Inn & Suites Mayo Clinic Area

2.9 km from Mayo Clinic Hospital - Saint Marys Campus

Cassandra

RM309

RM360 total

includes taxes & fees

5 Sept - 6 Sept

View all properties

Compare popular hotels close to Mayo Clinic Hospital - Saint Marys Campus

Property	Property class	Guest rating
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys	9.4 Exceptional 736 reviews	View
Home2 Suites by Hilton Rochester Mayo Clinic Area	9.6 Exceptional 1,007 reviews	View
Hilton Rochester Mayo Clinic Area	9.6 Exceptional 641 reviews	View
TownePlace Suites by Marriott Rochester Mayo Clinic Area	9.6 Exceptional 553 reviews	View
Residence Inn by Marriott Rochester Mayo Clinic Area South	9.6 Exceptional 301 reviews	View

Top Mayo Clinic Hospital - Saint Marys Campus Hotel Reviews

Aspen Select

10/10 Excellent

"Nice older hotel right across the street from the Mayo Clinics St. Mary's hospital. Reasonably priced, includes parking and breakfast! I will stay there again on my next trip to Rochester."

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent

"This is my first time staying at Hotel Indigo. The staff was amazing. I had to keep adding nights and they were so accommodating. The room was just right. It was clean , well stocked and easy access to the Mayo Clinic. I really liked the front desk people. Super friendly and helpful. Love the attached restaurant!"

Med City Inn & Suites - Mayo Clinic Area

8/10 Good

"From the outside the hotel looks outdated. The rooms were good outdated but clean. A mile away from downtown area. Attached to Dave’s barbecue which was good. Grocery and laundry nearby and on the bus route. Hotel staff helpful with a coffee and a breakfast served every morning I would definitely book again."

Brentwood Inn & Suites

10/10 Excellent

"The hotel is not super modern and it does not have super swank amenities, but the room was spotless, the staff were lovely, the breakfast was ample and easy for grab ‘n’ go, and the air conditioner in my room kept me nice and ICY cold during a horrendous heatwave. The property is in easy walking distance of the Domatilla Building (if you are a walker). I would definitely recommend this hotel. It’s very charming."

TownePlace Suites by Marriott Rochester Mayo Clinic Area

10/10 Excellent

"Great staff"

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

8/10 Good

"the pool deck was very slippery."

The Berkman

10/10 Excellent

"This was a very nice hotel located in downtown. It’s directly across from Mayo. The concierge checked each guest in and very helpful. This nice touch made the experience extra special."

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

10/10 Excellent

"Great experience start to finish"

Aspen Suites

10/10 Excellent

"Over the past 3 years we stayed at many Mayo Clinic area hotels but Aspen Suites was special. Each and every reception desk person was super helpful and friendly. The room with its comfy bed and couch and recliner was spacious and clean. I loved the roomy and inviting shower stall where I didn’t have to climb into a small bathtub to take a shower. The desk came with an internet connection and the kitchen was equipped for a long term stay with a full sized refrigerator. The food offerings were above every other hotel. I will come back here on my next visit to Rochester."

Frequently asked questions

What's the area like around Mayo Clinic Hospital - Saint Marys Campus?

Mayo Clinic Hospital - Saint Marys Campus is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, take a look at the 126 hotels and other accommodation options you'll find within a mile.

Where is the best place to stay near Mayo Clinic Hospital - Saint Marys Campus?

Adjacent to Mayo Clinic Hospital - Saint Marys Campus, EVEN Hotel Rochester - Mayo Clinic Area by IHG is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an indoor pool. Other good options within a short distance include Kahler Grand Hotel and Med City Inn & Suites - Mayo Clinic Area.

How many hotels are there close to Mayo Clinic Hospital - Saint Marys Campus?

Expedia has 126 hotels and other accommodation options within a mile from Mayo Clinic Hospital - Saint Marys Campus.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Hospital - Saint Marys Campus, will I receive a refund?

Yes! The majority of room reservations are fully refundable if cancelled before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within 24 hours of your booking. Put your dates in and click on "Search", then filter by "fully refundable" to view the best options available near Mayo Clinic Hospital - Saint Marys Campus.

What can I see and do near Mayo Clinic Hospital - Saint Marys Campus?

You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Sights like Plummer House and Assisi Heights highlight some of the local culture. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

Hotels near Mayo Clinic Hospital - Saint Marys Campus

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mayo Clinic Hospital - Saint Marys Campus hotels

1. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

2. Home2 Suites by Hilton Rochester Mayo Clinic Area

3. Hilton Rochester Mayo Clinic Area

4. TownePlace Suites by Marriott Rochester Mayo Clinic Area

5. Residence Inn by Marriott Rochester Mayo Clinic Area South

6. The Berkman

7. EVEN Hotel Rochester - Mayo Clinic Area by IHG

8. Staybridge Suites Rochester - Mayo Clinic Area by IHG

9. The Towers At Kahler Grand Hotel

10. Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

11. Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

12. Candlewood Suites Rochester Mayo Clinic Area by IHG

13. Broadway Plaza, Trademark Collection by Wyndham

14. Hampton Inn Rochester-South

15. Hyatt House Rochester/Mayo Clinic Area

16. Aspen Suites

17. Brentwood Inn & Suites

18. Hotel Indigo Rochester – Mayo Clinic Area by IHG

19. Hilton Garden Inn Rochester Downtown, MN

20. Quality Inn & Suites Mayo Clinic Area

Compare popular hotels close to Mayo Clinic Hospital - Saint Marys Campus

Top Mayo Clinic Hospital - Saint Marys Campus Hotel Reviews

Aspen Select

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Med City Inn & Suites - Mayo Clinic Area

Brentwood Inn & Suites

TownePlace Suites by Marriott Rochester Mayo Clinic Area

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

The Berkman

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Aspen Suites

Frequently asked questions

Explore a world of travel with Expedia