Photo by Hazem Abdul

Hotels in South Main, Houston

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Property class

Top 10 Hotels in South Main, Houston

Hyatt Regency Houston/Galleria

4.0 star property
8.8 out of 10, Excellent, (1006)
"Great accommodation and service highly recommend"
The price is RM574
RM677 total
includes taxes & fees
1 Aug - 2 Aug
Hyatt Regency Houston/Galleria

Hilton Garden Inn Houston/Bush Intercontinental Airport

3.0 star property
8.2 out of 10, Very good, (1010)
"priced right, well located, staff was wonderful and the bar was great!"
The price is RM405
RM476 total
includes taxes & fees
18 Jul - 19 Jul
Hilton Garden Inn Houston/Bush Intercontinental Airport

Blossom Hotel Houston

4.0 star property
9.2 out of 10, Wonderful, (3401)
"Amazing stay"
The price is RM591
RM691 total
includes taxes & fees
21 Jul - 22 Jul
Blossom Hotel Houston

Comfort Suites near Texas Medical Center - NRG Stadium

2.5 star property
8.6 out of 10, Excellent, (944)
"Great location close to nrg stadium rooms were good and breakfast was great"
The price is RM340
RM398 total
includes taxes & fees
2 Aug - 3 Aug
Comfort Suites near Texas Medical Center - NRG Stadium

Wyndham Houston near NRG Park/Medical Center

3.5 star property
7.2 out of 10, Good, (1117)
"Very conveniently located for concerts."
The price is RM400
RM468 total
includes taxes & fees
21 Jul - 22 Jul
Wyndham Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

3.0 star property
6.6 out of 10, (923)
"This property is only good for convenience, breakfast is just store bought muffins and box cereal. Rooms are dirty with a sketchy connecting door, has an odd odor too."
The price is RM336
RM393 total
includes taxes & fees
15 Jul - 16 Jul
Wingate Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
6.4 out of 10, (1006)
"Vanessa and everyone at front desk was extremely accommodating & gracious. The BEST out of the whole stay. Thank yall so much "
The price is RM249
RM292 total
includes taxes & fees
13 Aug - 14 Aug
Quality Inn & Suites NRG Park - Medical Center

Candlewood Suites Houston Medical Center by IHG

2.5 star property
7.4 out of 10, Good, (782)
"Convenient to where I wanted to be staff was nice too"
The price is RM286
RM334 total
includes taxes & fees
20 Jul - 21 Jul
Candlewood Suites Houston Medical Center by IHG

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

3.0 star property
8.2 out of 10, Very good, (603)
"We enjoyed our stay."
The price is RM325
RM380 total
includes taxes & fees
16 Jul - 17 Jul
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

Palace Inn Blue Edgebrook

2.5 star property
9.4 out of 10, Exceptional, (123)
"Really great hospitality"
The price is RM327
RM394 total
includes taxes & fees
15 Jul - 16 Jul
Palace Inn Blue Edgebrook

Moxy Houston Downtown

3.0 star property
9.0 out of 10, Wonderful, (505)
"Cool place!!"
The price is RM514
RM612 total
includes taxes & fees
18 Jul - 19 Jul
Moxy Houston Downtown

Sheraton North Houston at George Bush Intercontinental

3.5 star property
8.0 out of 10, Very good, (1001)
"Very clean and the staff was awesome "
The price is RM431
RM504 total
includes taxes & fees
8 Aug - 9 Aug
Sheraton North Houston at George Bush Intercontinental

Hyatt Place Houston Medical Center

3.0 star property
9.2 out of 10, Wonderful, (1797)
"The staff is exceptional and the location of the hotel was exactly what we were looking for. "
The price is RM493
RM580 total
includes taxes & fees
18 Jul - 19 Jul
Hyatt Place Houston Medical Center

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

3.0 star property
8.8 out of 10, Excellent, (1447)
"Thank you, great hotel and enjoyable stayed😍"
The price is RM373
RM438 total
includes taxes & fees
9 Aug - 10 Aug
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Bluestar Inn

2.5 star property
9.0 out of 10, Wonderful, (252)
"Nice place at a good rate "
The price is RM255
RM298 total
includes taxes & fees
15 Jul - 16 Jul
Bluestar Inn

Americas Best Value Inn & Suites NE Houston Downtown I-610

2.0 star property
8.6 out of 10, Excellent, (594)
"Always clean and close to downtown. "
The price is RM310
RM363 total
includes taxes & fees
15 Jul - 16 Jul
Americas Best Value Inn & Suites NE Houston Downtown I-610

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

3.0 star property
8.8 out of 10, Excellent, (1020)
"Great place to stay "
The price is RM358
RM411 total
includes taxes & fees
15 Jul - 16 Jul
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Haven Inn & Suites Downtown Houston

2.5 star property
9.4 out of 10, Exceptional, (1005)
"Nice place to stay"
Haven Inn & Suites Downtown Houston

Best Western Plus Hobby Airport Inn & Suites

2.5 star property
8.8 out of 10, Excellent, (1186)
"I will definitely stay here again"
The price is RM325
RM380 total
includes taxes & fees
22 Jul - 23 Jul
Best Western Plus Hobby Airport Inn & Suites

Days Inn & Suites by Wyndham Downtown/University of Houston

2.0 star property
8.0 out of 10, Very good, (673)
"Better breakfast, needs more towels, needs assigned parking "
The price is RM249
RM292 total
includes taxes & fees
17 Jul - 18 Jul
Days Inn & Suites by Wyndham Downtown/University of Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
Downtown Houston map

Downtown Houston

3 out of top 10 points of interest in this area

Gourmet restaurants acclaimed theatres and top sights from Toyota Center to Daikin Park – discover Downtown Houston, a destination also famous for its sports teams.

The Galleria map

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center map

Texas Medical Center

1 out of top 10 points of interest in this area

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose map

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.

Houston Central Business District map

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Main Street Square Station.

Frequently asked questions

What is South Main like?

You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.

Where is the best hotel for a stay in South Main?

Based on Expedia customer reviews, Comfort Suites near Texas Medical Center - NRG Stadium is the highest ranked property in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.

How many hotels should I expect to find in South Main?

If you're searching for places to stay in Houston, Expedia has something to meet your needs with 62 South Main hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in South Main, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.

What can I see and do in this Houston neighbourhood?

NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.

How can I get around South Main and the greater Houston area?

Ready to get out and explore the city? Fannin South Station is the closest metro station.