A calm lake surrounded by trees and vegetation.

Southwest Illinois Spa Hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southwest Illinois Hotels with Spa

Tonight
29 Sept - 30 Sept
Tomorrow
30 Sept - 1 Oct
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

Our top choices for Southwest Illinois hotels with a spa

A modern spa room with a large hot tub, a glass wall with a reflective pattern, and a ceiling with a skylight.
A hotel lobby with a marble floor, a reception area with a '12 & VINE' sign, and a dining area with orange chairs and chandeliers.
A hotel reception desk with a modern chandelier, a sign indicating 'SPA' coming soon, and two receptionists at their stations.
A hotel lobby with a marble floor, a reception desk, a sign for 'Restrooms', and a large chandelier.

1. Walker's Bluff Casino Resort

Walker's Bluff Casino Resort
Carterville
  • Luxurious spa retreat with hot stone massages, sauna, and seasonal pools awaits at this casino resort with attentive staff and fine dining.
RM698
RM774 total
includes taxes & fees
25 Oct - 26 Oct
Walker's Bluff Casino Resort
A bathroom with a white sink, dark wooden door, and a shower area with striped glass walls.
A modern interior with a staircase, a large abstract painting, and a seating area with a glass coffee table.
A room with a bed, a nightstand with a lamp, a painting on the wall, and a radiator.
A two-story building with a dark entrance, large windows, and a brick facade.

2. Truitt Hotel

Truitt Hotel
Lafayette Square
RM686
RM833 total
includes taxes & fees
1 Oct - 2 Oct
Truitt Hotel
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.

3. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
  • Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
RM404
RM460 total
includes taxes & fees
29 Oct - 30 Oct
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A reception desk with a wooden finish and the name "IDOL WOLF" on it.
A modern bathroom with a bathtub, a vanity with a mirror, and a shower area.
A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.
A spacious lobby with a large spherical sculpture, a seating area, and a view of the outside through a large window.

4. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
Downtown West
  • Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
RM586
RM706 total
includes taxes & fees
25 Oct - 26 Oct
21C Museum Hotel St Louis
A modern spa with a curved reception desk, a large mirror, and a decorative water feature.
A bar area with multiple seating arrangements, a stage, and a chandelier.
A modern tavern with a large sign, glass doors, and indoor seating visible through the windows.
An indoor swimming pool with clear glass walls, metal railings, and a tiled floor.

5. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
St. Charles
  • Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
RM609
RM780 total
includes taxes & fees
13 Oct - 14 Oct
Ameristar Casino Resort and Spa
A couple relaxing by a window overlooking a bridge and water.
A room with large windows overlooking a bridge and water, featuring wooden chairs and a small table.
A modern dining area with a long table set for a meal, large windows offering a view of a bridge, and a stone accent wall.
A bar area with a bartender, a bar counter with various bottles, and a view of the Gateway Arch.

6. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
Downtown St. Louis
  • Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
RM1,531
RM1,790 total
includes taxes & fees
4 Oct - 5 Oct
Four Seasons Hotel St Louis
A modern kitchen with wooden cabinets, a central island, and framed artwork on the walls.
A couple standing on a balcony with a cityscape view.
A bar area with leather seating, a bar counter, and shelves of bottles.
An outdoor seating area with modern furniture, a bar, and large windows offering views of a cityscape.

7. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
Clayton
  • Revel in a rejuvenating spa retreat with aromatherapy treatments and hot stone massages at this luxury St. Louis hotel.
RM2,527
RM2,950 total
includes taxes & fees
26 Oct - 27 Oct
The Ritz-Carlton, St. Louis
View all properties

Choose what matters most at spa hotels in Southwest Illinois

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Southwest Illinois Hotel Reviews

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

10/10 Excellent
"Everything was great clean staff was great food was great can’t wait to go back"
Barbara 1-night trip
Posted 6 hours ago
Drury Plaza Hotel Mt. Vernon
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

8/10 Good
"Finally a room with a walk in shower and grab bars by toilet"
Anjanette 1-night trip
Posted 13 hours ago
Comfort Suites Mount Vernon
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent
"Fabulous that I arrived & had Happy Hour Meal with Drinks & a great breakfast! Thx! Dennis D."
Dennis 1-night trip
Posted 1 day ago
Drury Inn & Suites St. Louis O'Fallon, IL

Explore a world of travel with Expedia