Hotels in South Main, Houston

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19 Dec - 20 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for South Main hotels

Lobby
Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1005)
"Clean room, helpful staff and good location to hospital."
United States
George
The price is RM362
RM423 total
includes taxes & fees
1 Jan - 2 Jan 2026
Comfort Suites Houston near Medical Center- NRG Stadium
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1002)
"Clean rooms, quiet property. We will be back again. "
United States
Javier
The price is RM217
RM253 total
includes taxes & fees
18 Jan - 19 Jan 2026
Quality Inn & Suites NRG Park - Medical Center
Gazebo
Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (989)
"Great staff, excellent service and convenient to the area we were wanting to be. Room was clean and bed was very comfortable."
United States
Roy
The price is RM282
RM330 total
includes taxes & fees
22 Dec - 23 Dec
Wingate Houston near NRG Park/Medical Center
Lobby
Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1203)
"Love this place. Been staying here for many years. "
United States
Reynaldo
The price is RM364
RM425 total
includes taxes & fees
15 Jan - 16 Jan 2026
Wyndham Houston near NRG Park/Medical Center
Exterior
Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (824)
"This is a safe, friendly hotel close to MDA Cancer Center"
United States
Myra
The price is RM286
RM335 total
includes taxes & fees
22 Dec - 23 Dec
Candlewood Suites Houston Medical Center by IHG
Exterior
Hilton Americas-Houston

Hilton Americas-Houston

Hilton Americas-Houston
4.0 star property
10.4 km from South Main
9.4 out of 10, Exceptional, (1605)
"Great hotel. Lively bar, great breakfast, friendly staff, nice room, close to everything. "
United States
Thomas
The price is RM568
RM672 total
includes taxes & fees
1 Jan - 2 Jan 2026
Hilton Americas-Houston
City view
Hyatt Regency Houston Downtown

Hyatt Regency Houston Downtown

Hyatt Regency Houston Downtown
4.0 star property
Houston Central Business District, 10.5 km from South Main
9.2 out of 10, Wonderful, (1094)
"Great staff and nice room. "
United States
Nikiesha
The price is RM609
RM738 total
includes taxes & fees
21 Dec - 22 Dec
Hyatt Regency Houston Downtown
Exterior
The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria, 8.8 km from South Main
8.4 out of 10, Very good, (1468)
"Wonderful hotel!"
United States
Debbie
The price is RM454
RM532 total
includes taxes & fees
23 Dec - 24 Dec
The Royal Sonesta Houston Galleria
Lobby
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Houston Central Business District, 10.9 km from South Main
8.4 out of 10, Very good, (3941)
"Rooms were great and the staff was absolutely amazing. "
United States
Elmer
The price is RM299
RM349 total
includes taxes & fees
20 Dec - 21 Dec
Club Quarters Hotel Downtown, Houston
Lobby sitting area
Hyatt Place Houston Downtown

Hyatt Place Houston Downtown

Hyatt Place Houston Downtown
3.0 star property
Houston Central Business District, 11 km from South Main
9.0 out of 10, Wonderful, (1567)
"Great service, room was relaxing. "
United States
Alice
The price is RM389
RM466 total
includes taxes & fees
21 Dec - 22 Dec
Hyatt Place Houston Downtown
Premium bedding, desk, iron/ironing board, free WiFi
Platinum Inn & Suites Webster

Platinum Inn & Suites Webster

Platinum Inn & Suites Webster
3.0 star property
30.8 km from South Main
7.8 out of 10, Good, (1001)
"It was a great stay just perfect"
United States
elvin
The price is RM257
RM301 total
includes taxes & fees
22 Dec - 23 Dec
Platinum Inn & Suites Webster
Lobby
Embassy Suites Houston Downtown

Embassy Suites Houston Downtown

Embassy Suites Houston Downtown
3.5 star property
10.4 km from South Main
9.2 out of 10, Wonderful, (1007)
"Best stay ever! Great location, easy to get to, and the amenities are outstanding!!!"
United States
Robert
The price is RM499
RM584 total
includes taxes & fees
29 Dec - 30 Dec
Embassy Suites Houston Downtown
Outdoor pool
Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.8 km from South Main
9.0 out of 10, Wonderful, (1001)
"The staff was super nice and the location worked great for us! "
Mexico
Valeria
The price is RM315
RM368 total
includes taxes & fees
8 Jan - 9 Jan 2026
Tru by Hilton Houston Webster NASA
View from property
Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel
4.0 star property
Downtown Houston, 11.1 km from South Main
9.2 out of 10, Wonderful, (1340)
"The staff was very nice and helpful and the hotel was clean "
United States
Christy
The price is RM427
RM512 total
includes taxes & fees
21 Dec - 22 Dec
Magnolia Hotel Houston, A Tribute Portfolio Hotel
Interior
Omni Houston Hotel

Omni Houston Hotel

Omni Houston Hotel
4.0 star property
10.6 km from South Main
9.0 out of 10, Wonderful, (1001)
"A great place to stay "
United States
Juan
The price is RM650
RM772 total
includes taxes & fees
21 Dec - 22 Dec
Omni Houston Hotel
Property amenity
Holiday Inn Houston Downtown by IHG

Holiday Inn Houston Downtown by IHG

Holiday Inn Houston Downtown by IHG
3.0 star property
Houston Central Business District, 10 km from South Main
8.6 out of 10, Excellent, (1604)
"Comfortable stay, clean room, felt safe and really friendly staff."
Australia
Thomas
The price is RM380
RM489 total
includes taxes & fees
25 Dec - 26 Dec
Holiday Inn Houston Downtown by IHG
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, pool loungers
Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria
4.0 star property
The Galleria, 8.7 km from South Main
9.0 out of 10, Wonderful, (1177)
"Great property! "
United States
Lynn
The price is RM429
RM627 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hyatt Regency Houston/Galleria
Lobby
Hampton Inn Houston Downtown

Hampton Inn Houston Downtown

Hampton Inn Houston Downtown
2.5 star property
10.8 km from South Main
8.8 out of 10, Excellent, (1003)
"Great fresh breakfast easy access to things around you and great service "
United States
Angel
The price is RM399
RM467 total
includes taxes & fees
25 Dec - 26 Dec
Hampton Inn Houston Downtown
Premium bedding, Tempur-Pedic beds, desk, laptop workspace
Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
3.5 star property
6.5 km from South Main
7.8 out of 10, Good, (1265)
"Enjoyed my stay at hotel "
United States
Reginald
The price is RM274
RM320 total
includes taxes & fees
6 Jan - 7 Jan 2026
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Restaurant
Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria
3.0 star property
8.7 km from South Main
8.8 out of 10, Excellent, (1269)
"Great location "
United States
Ramon Alejandro Caballero
The price is RM384
RM452 total
includes taxes & fees
28 Dec - 29 Dec
Hyatt Place Houston/Galleria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
Discovery Green which includes a skyscraper, a city and modern architecture

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more of the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Houston Heights

You'll enjoy the coffee shops and live music in Houston Heights. You might want to make time for a stop at The Heights Theater or Artcar Museum.

Top South Main Hotel Reviews

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

10/10 Excellent
"Staff was very friendly "
Ashley Marie 1-night trip
Posted 1 day ago
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness centre. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

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