Hotels in South Main, Houston
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.0 out of 10, Good, (1,295 reviews)
"Would stay again!"
Austin
The price is RM356
RM417 total
includes taxes & fees
10 May - 11 May
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,002 reviews)
"Had a great stay!"
Hunter
The price is RM335
RM392 total
includes taxes & fees
31 May - 1 Jun
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Great location"
Jeremy
The price is RM278
RM325 total
includes taxes & fees
27 May - 28 May
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (860 reviews)
"My stay was perfect "
Fredrick
The price is RM257
RM301 total
includes taxes & fees
31 May - 1 Jun
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,003 reviews)
"Very clean rooms and excellent staff"
Efrain
The price is RM281
RM329 total
includes taxes & fees
19 May - 20 May
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.6 out of 10, Exceptional, (57 reviews)
"Wonderful stay and well worth the price."
Francis
The price is RM270
RM316 total
includes taxes & fees
17 May - 18 May
Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd19.4 km from South Main
9.2 out of 10, Wonderful, (51 reviews)
"Very nice clean quiet property close to many restaurants."
Hilary and Cynthia
The price is RM403
RM472 total
includes taxes & fees
6 May - 7 May
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (168 reviews)
"Nice place to stay"
Bella
The price is RM360
RM434 total
includes taxes & fees
6 May - 7 May
Hotel Royale
Hotel Royale20.9 km from South Main
9.2 out of 10, Wonderful, (31 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is RM320
RM375 total
includes taxes & fees
6 May - 7 May
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (239 reviews)
"Simply amazing stay "
Jesus
The price is RM335
RM392 total
includes taxes & fees
10 May - 11 May
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,213 reviews)
"Wonderful place to stay!"
Lisa
The price is RM495
RM579 total
includes taxes & fees
8 May - 9 May
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,866 reviews)
"Clean, comfy beds & friendly staff!"
Andrea
The price is RM348
RM409 total
includes taxes & fees
1 Jun - 2 Jun
SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,744 reviews)
"wonderful stay "
Stepfan
The price is RM417
RM488 total
includes taxes & fees
30 May - 31 May
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham18.5 km from South Main
8.8 out of 10, Excellent, (1,156 reviews)
"Clean, helpful staff, absolutely loved the pool and breakfast. Would definitely stay again. "
Desiree
The price is RM333
RM383 total
includes taxes & fees
10 May - 11 May
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.2 out of 10, Very good, (1,925 reviews)
"Breakfast was good, love everything about this place."
John
The price is RM367
RM429 total
includes taxes & fees
10 May - 11 May
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,007 reviews)
"Breakfast was great"
Tracy
The price is RM320
RM374 total
includes taxes & fees
24 May - 25 May
Best Western Plus Manvel Inn & Suites
Best Western Plus Manvel Inn & Suites22.6 km from South Main
8.8 out of 10, Excellent, (781 reviews)
"Everything about this place was awesome. Will definitely be staying there again on my next trip!!!!!"
Penny
The price is RM316
RM357 total
includes taxes & fees
19 May - 20 May
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,005 reviews)
"Great short stay!!!"
BriAnna
The price is RM352
RM412 total
includes taxes & fees
10 May - 11 May
Home2 Suites by Hilton Houston Pasadena
Home2 Suites by Hilton Houston Pasadena24.3 km from South Main
9.4 out of 10, Exceptional, (871 reviews)
"Wedding trip
Perfect short stay"
Pawel
The price is RM425
RM497 total
includes taxes & fees
22 May - 23 May
Spark by Hilton Houston Bush Intercontinental Airport
Spark by Hilton Houston Bush Intercontinental Airport31.2 km from South Main
8.6 out of 10, Excellent, (1,003 reviews)
"Great option close to the airport! "
Lisa
The price is RM343
RM401 total
includes taxes & fees
23 May - 24 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,002 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 860 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.0 Good 1,295 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,001 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,003 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
4/10 Poor
