A calm lake with mountains in the background.

Seneca hotels from RM262

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Check prices for these dates

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30 Aug - 31 Aug
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31 Aug - 1 Sept
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4 Sept - 6 Sept
In two weeks
11 Sept - 13 Sept

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Our top choices for Seneca hotels

1. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
United States
Ronald
RM483
RM531 total
includes taxes & fees
6 Sept - 7 Sept
Fairfield Inn & Suites Seneca Clemson Univ Area

2. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
United States
Susana
RM426
RM468 total
includes taxes & fees
13 Sept - 14 Sept
Tru by Hilton Seneca Clemson

3. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
United States
Georgina
RM478
RM525 total
includes taxes & fees
3 Sept - 4 Sept
Hampton Inn & Suites Seneca-Clemson Area

4. Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
United States
Anthony
RM304
RM359 total
includes taxes & fees
6 Sept - 7 Sept
Quality Inn Seneca US-123

5. Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
United States
Christopher
RM439
RM545 total
includes taxes & fees
31 Aug - 1 Sept
Lakeside Lodge Clemson

6. Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
United States
Michelle
RM390
RM429 total
includes taxes & fees
1 Sept - 2 Sept
Best Western Seneca-Clemson

7. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
United States
John
RM338
RM372 total
includes taxes & fees
6 Sept - 7 Sept
Days Inn by Wyndham Seneca / Clemson Area

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
United States
Nirumol
RM373
RM587 total
includes taxes & fees
3 Sept - 4 Sept
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

9. Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
Clemson
United States
Bill
RM600
RM666 total
includes taxes & fees
1 Sept - 2 Sept
Clemson University's James F. Martin Inn

10. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Robert
RM612
RM680 total
includes taxes & fees
2 Sept - 3 Sept
The Abernathy of Clemson

11. Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
Clemson
United States
DOUGLAS
RM426
RM473 total
includes taxes & fees
6 Sept - 7 Sept
Hampton Inn Clemson-University Area

12. Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
Clemson
United States
Anita
RM414
RM460 total
includes taxes & fees
20 Sept - 21 Sept
Comfort Inn & Suites Clemson - University Area

13. The Inn at Patrick Square

The Inn at Patrick Square
Clemson
United States
Beatriz
RM600
RM666 total
includes taxes & fees
31 Aug - 1 Sept
The Inn at Patrick Square

14. Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
Clemson
United States
Karen
RM407
RM452 total
includes taxes & fees
1 Sept - 2 Sept
Best Western Plus Clemson Hotel & Conference Center

15. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
RM962
RM1,068 total
includes taxes & fees
6 Sept - 7 Sept
The Shepherd Hotel Downtown Clemson

16. Inn @ Clemson

Inn @ Clemson
Clemson
United States
Terry
RM322
RM358 total
includes taxes & fees
31 Aug - 1 Sept
Inn @ Clemson

17. Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
Walhalla
United States
michael
RM308
RM343 total
includes taxes & fees
29 Sept - 30 Sept
Rodeway Inn & Suites Walhalla

18. Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
Clemson
United States
Angela
RM443
RM491 total
includes taxes & fees
7 Sept - 8 Sept
Holiday Inn Express & Suites Clemson by IHG

19. Courtyard Marriott Clemson

Courtyard Marriott Clemson
Clemson
United States
Gargi
RM474
RM526 total
includes taxes & fees
8 Sept - 9 Sept
Courtyard Marriott Clemson

20. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
Pendleton
RM499
RM554 total
includes taxes & fees
13 Sept - 14 Sept
Liberty Hall Bed and Breakfast
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Holiday Rentals in Seneca

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
"Me and my family had a great time"
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Cottage

8 Mi to Clemson: Peaceful Family Home w/ Yard

8 Mi to Clemson: Peaceful Family Home w/ Yard
Seneca
"The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much."
8 Mi to Clemson: Peaceful Family Home w/ Yard
Apartment

Screened Patio & Yard: Clemson Weekends/lakes Stay

Screened Patio & Yard: Clemson Weekends/lakes Stay
Seneca
"The townhome was perfect for our sonโ€™s graduation weekend. Very easy ride to Clemson campus. The kitchen was well appointed with what u need to cook. The place was clean and well cared for. Hosts were very helpful and responded quickly to questions. Thanks for a great stay!"
Screened Patio & Yard: Clemson Weekends/lakes Stay
Cottage

Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar

Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar
Seneca
"The best, perfect "
Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar
Cottage

Lake Hartwell Home w/ Dock < 10 Miles to Clemson!

Lake Hartwell Home w/ Dock < 10 Miles to Clemson!
Seneca
"The home was adorable and served its purpose for our trip. We will definitely book again."
Lake Hartwell Home w/ Dock < 10 Miles to Clemson!
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Where to stay in Seneca

Find the best Seneca areas for the activities you enjoy most.

Downtown

City centre Seneca captures the essence of small-town Southern charm with its well-preserved railway heritage and historic brick buildings. Tree-lined streets lead to charming shops and local eateries housed in structures dating back to the 1800s. Ram Cat Alley's colourful murals tell stories of local history while the old courthouse square hosts community gatherings. This walkable district offers a peaceful retreat from big city life. Visitors can browse antique stores for railway memorabilia, sample authentic Southern comfort food, or explore the cultural exhibits at the Bertha Lee Strickland Museum. The nearby Lake Keowee provides outdoor recreation just minutes away.

Serenity Bay

Serenity Bay offers a peaceful retreat within Saxony Forest's coastal embrace. The quiet residential streets wind through mature trees, creating a tranquil atmosphere away from tourist crowds. Nature lovers can explore nearby Lake Keowee or enjoy the neighborhood's forest trails. The area perfectly balances woodland serenity with beach proximity. Visitors should plan for self-contained holiday rentals rather than hotels. While dining options are limited within the area, the natural surroundings provide ideal conditions for relaxation and outdoor recreation.

Pine Ridge Point

Lake Keowee's serene waters lap against the shores of Pine Ridge Point, a tranquil residential haven in Seneca. Private docks stretch into crystal-clear waters where boats gently bob. Towering pines create natural privacy between lakefront homes. Visitors enjoy peaceful mornings watching mist rise over the water. This area offers an authentic lakeside living experience without tourist crowds. Holiday rentals range from cosy cabins to luxury estates with private boat slips. Days revolve around swimming, fishing, and water sports on Lake Keowee. Nature trails wind through mature forests for hiking and birdwatching.

Indian Oaks

Indian Oaks offers a tranquil retreat in suburban Seneca where mature oak trees create natural canopies over peaceful residential streets. This family-oriented community provides an authentic glimpse into American suburban living without tourist crowds. Landscaped yards and community green spaces showcase South Carolina's native beauty. Visitors can enjoy quiet morning walks on spacious pavements while listening to birdsong. Lake Keowee lies just beyond the area boundaries for those seeking water activities. With minimal commercial presence, Indian Oaks delivers a genuinely restful experience away from urban bustle.

Stay near popular Seneca attractions

A grassy field with yellow flowers and trees in the foreground, with mountains in the background.

Blue Ridge Field

This historic park honours African-American education in Oconee County on the former Blue Ridge High School football grounds. Stroll the paved loop trail and explore community gardens in this peaceful green space.
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A waterfall surrounded by autumn foliage.

High Falls County Park

Nestled along Lake Keowee with the Blue Ridge Mountains as backdrop, High Falls County Park offers pristine swimming and camping spots. Reserve waterfront campsites early to enjoy the park's serene natural setting.
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Oconee County Library Seneca Branch

This welcoming community hub offers reading materials, digital resources, and programmes for all ages. Explore seasonal events like storytimes, trivia contests, and craft workshops in a tranquil learning environment.
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South Cove Park

This lakeside retreat on Lake Keowee offers pristine beaches, boat ramps, and scenic picnic spots. Enjoy fishing, swimming, or simply relaxing amid the natural beauty of upstate South Carolina.
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Friendship Recreation Area

After visiting Friendship Recreation Area, make a plan to see the other sights and activities in Seneca. Stroll along the lakeside or attend a sporting event in this family-friendly area.
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Seneca City Hall

Seneca City Hall is just one of the places to see in Seneca, so why not enjoy the other things to explore during your travels?
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Highpointe Lower Field

Highpointe Lower Field is just one of the places to see in Seneca, so why not enjoy the other things to explore during your travels? Stroll along the lakeside or attend a sporting event in this family-friendly area.
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The Gauntlet

You can make plans for a show at The Gauntlet during your trip to Seneca.
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Learn more about Seneca

Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

See all hotels in Seneca
A calm lake with mountains in the background.

Top Seneca Hotel Reviews

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

10/10 Excellent
"Staff were nice and accommodating"
Rosario 3-night trip
Posted 7 hours ago
Days Inn by Wyndham Seneca / Clemson Area
Lakeside Lodge Clemson

Lakeside Lodge Clemson

10/10 Excellent
"Loved everything while there. We always look stay here"
Christopher 4-night trip
Posted 12 hours ago
Lakeside Lodge Clemson
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

10/10 Excellent
"Great breakfast."
Karen 1-night trip
Posted 1 day ago
Best Western Plus Clemson Hotel & Conference Center
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

10/10 Excellent
"Great hotel. Beautiful, fresh decor. Loved the rooftop and the 3rd floor bar area and terrace. Right in the middle of all the action. A great place to stay if you are touring/visiting Clemson University."
Jennifer 2-night trip
Posted 1 day ago
The Shepherd Hotel Downtown Clemson
Quality Inn Seneca US-123

Quality Inn Seneca US-123

10/10 Excellent
"Convenient location. Reasonably priced. Staff is very friendly and helpful."
Kwanchanok 1-night trip
Posted 3 days ago
Quality Inn Seneca US-123
Inn @ Clemson

Inn @ Clemson

10/10 Excellent
"Itโ€™s"
Julie 3-night trip
Posted 3 days ago
Inn @ Clemson
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

10/10 Excellent
"room was clean and modern, very nice"
ann 1-night trip
Posted 4 days ago
Comfort Inn & Suites Clemson - University Area
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

10/10 Excellent
"All well"
Pankaj 2-night trip
Posted 4 days ago
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
The Abernathy of Clemson

The Abernathy of Clemson

10/10 Excellent
"The property was clean and had great access to Clemson University. The staff was very nice accommodating."
Melanie 2-night trip
Posted 5 days ago
The Abernathy of Clemson

More cheap stays in Seneca

Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

1007 George Smith Mill Rd Anderson SC
RM236
RM262 total
15 Sept - 16 Sept
includes taxes & fees
Days Inn by Wyndham Anderson
Inn @ Clemson

Inn @ Clemson

1303 Tiger Blvd Clemson SC
RM322
RM358 total
31 Aug - 1 Sept
includes taxes & fees
8/10 Very good! (1,000 reviews)
Inn @ Clemson
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

1310 Tiger Blvd Clemson SC
RM407
RM452 total
1 Sept - 2 Sept
includes taxes & fees
Best Western Plus Clemson Hotel & Conference Center
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

1305 Tiger Blvd Clemson SC
RM414
RM460 total
20 Sept - 21 Sept
includes taxes & fees
Comfort Inn & Suites Clemson - University Area
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

107 Interstate Blvd Anderson SC
RM415
RM460 total
27 Sept - 28 Sept
includes taxes & fees
9.2/10 Wonderful! (653 reviews)
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
Lakeside Lodge Clemson

Lakeside Lodge Clemson

13500 Clemson Blvd Seneca SC
RM439
RM545 total
31 Aug - 1 Sept
includes taxes & fees
9/10 Wonderful! (1,004 reviews)
Lakeside Lodge Clemson

Frequently asked questions

Where is the best place for a stay in Seneca?
Lakeside Lodge Clemson is one of the top choices for your stay based on our traveller data. This hotel offers a restaurant and free parking. Other good options for your visit include Fairfield Inn & Suites Seneca Clemson Univ Area and Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in Seneca.
If I need to cancel my hotel reservation in Seneca, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a reservation that's non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Seneca.
What's the best family accommodation in Seneca?
Fairfield Inn & Suites Seneca Clemson Univ Area is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Also, attractions in the area such as Ultimate Action Sports are fun for the whole family. Find more child-friendly accommodations in Seneca.
What is the top LGBTQ-friendly accommodation in Seneca?
Hampton Inn & Suites Seneca-Clemson Area is a top LGBTQ-friendly hotel that features free breakfast and free Wi-Fi. Tru by Hilton Seneca Clemson is another good choice for your trip. See all available hotels listed as LGBTQ-friendly in Seneca.
What's the best dog-friendly hotel in Seneca?
Lakeside Lodge Clemson is a top hotel for people travelling with their pets, and offers a restaurant and a seasonal outdoor pool for its human guests. Other good choices for you and your pet's trip include Tru by Hilton Seneca Clemson and Quality Inn Seneca US-123. See more pet-friendly hotel accommodations in Seneca.
What are some hotels with pools in Seneca?
Lakeside Lodge Clemson: Hotel located near Clemson University. Features free self parking, a seasonal outdoor pool and complimentary wireless Internet access. Fairfield Inn & Suites Seneca Clemson Univ Area and Quality Inn Seneca US-123 are two additional hotels that feature an on-site pool. View all hotels with pools in Seneca.
What is staying in Seneca like?
Visitors to Seneca will definitely enjoy the sporting events, lakeside setting and university setting. Welcoming and scenic, this city also attracts tourists with its cafes. In Seneca, there are 319 hotels and other accommodation options to choose from. Find out more about Seneca.
What should I see while I'm in Seneca?
Cultural venues include The Gauntlet and Oconee Community Theatre. Natural beauty is on display at Lake Keowee, Lake Hartwell and Keowee Reservoir. Exploring the waterfront is a great activity, and Keowee Key Golf Course is one place to visit. Take a look at what more there is to see and do in Expedia's Seneca guide.
What's the seasonal weather in Seneca?
The hottest months are usually July and August, with an average temperature of 25ยฐC, while the coldest months are January and February, with an average of 8ยฐC. Average annual precipitation for Seneca is 1565 mm.

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