Medical Center District

San Antonio

River walk in San Antonio
Tourists River Walk San Antonio Texas
Riverboat on the San Antonio River Walk, San Antonio, Texas, United States of America.
River walk in San Antonio
SanAntonio_SouthTexasMedicalCenter_6193120_01

Popular places to visit

Things to do


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is RM355 per night from 7 Jun to 8 Jun
RM355
RM420 total
7 Jun - 8 Jun
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (3,394 reviews)
"I was there on business. However, my stay was so welcoming and such a great experience. I will return!"

Reviewed on 3 Jun 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is RM404 per night from 19 Jun to 20 Jun
RM404
RM480 total
19 Jun - 20 Jun
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy a free local area shuttle, room service and a 24-hour fitness centre. Our guests praise the helpful ...
8.6/10 Excellent! (1,072 reviews)
"Very good"

Reviewed on 1 Jun 2026

San Antonio Marriott Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W San Antonio TX
The price is RM360 per night from 25 Jun to 26 Jun
RM360
RM425 total
25 Jun - 26 Jun
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,339 reviews)
"Very Clean rooms Staff nice and pleasant! Only problem was freeway sounds into my room at night! Motorbikes & big rigs, a few mussel cars general traffic. Then twice during the night, firetruck from the nearby fire station sirens blaring went past the Hotel midnight & two or three AM. Pool was great ..."

Reviewed on 3 Jun 2026

Drury Inn & Suites San Antonio Northwest Medical Center
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
The price is RM600 per night from 7 Jun to 8 Jun
RM600
RM709 total
7 Jun - 8 Jun
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and 2 hot tubs. Our guests praise the breakfast and the pool in their reviews. ...
9.4/10 Exceptional! (4,718 reviews)
"The free breakfast offered was spectacular!"

Reviewed on 4 Jun 2026

Drury Plaza Hotel San Antonio Riverwalk
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
The price is RM492 per night from 5 Jul to 6 Jul
RM492
RM696 total
5 Jul - 6 Jul
includes taxes & fees
Stay at this luxury hotel in San Antonio. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the clean rooms in ...
9.4/10 Exceptional! (2,788 reviews)
"Clean rooms, Staff was very helpful. Great coffee and service at the lobby coffee bar. Fully stocked bar with good selection of wines to enjoy on the patio."

Reviewed on 4 Jun 2026

Hotel Valencia Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
The price is RM356 per night from 7 Jun to 8 Jun
RM356
RM421 total
7 Jun - 8 Jun
includes taxes & fees
Stay at this family-friendly hotel in San Antonio. Enjoy free Wi-Fi, room service and a 24-hour fitness centre. Our guests praise the restaurant and the helpful ...
8/10 Very Good! (6,464 reviews)
"They have a projector and played the spurs westerns finals game and staff was super cool even made accommodations to watch it comfortably will book here again"

Reviewed on 2 Jun 2026

Riverwalk Plaza
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

Downtown San Antonio

A scenic riverfront great entertainment and top sights from San Antonio River to Alamo – discover Downtown San Antonio, a destination also famous for its historic sites.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Alamo Quarry Market are top sights worth seeing.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Stone Ridge Market and Shops at Hardy Oak while you're in town.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.



Medical Center District