Top 10 Medical Center District Hotels of 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Compare popular hotels in Medical Center District

Property	Property class	Guest rating
Drury Inn & Suites San Antonio Northwest Medical Center	3.0 star property	9.2 Wonderful 1,339 reviews	View
Fairfield Inn & Suites by Marriott San Antonio Medical Center	3.0 star property	9.0 Wonderful 1,006 reviews	View
Courtyard by Marriott Medical Center San Antonio	3.0 star property	8.8 Excellent 1,000 reviews	View
San Antonio Marriott Northwest Medical Center	3.5 star property	8.6 Excellent 1,072 reviews	View
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW	3.0 star property	8.4 Very good 3,397 reviews	View

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

See properties

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

See properties

Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Alamo Quarry Market are top sights worth seeing.

See properties

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Stone Ridge Market and Shops at Hardy Oak while you're in town.

See properties

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

See properties

Top Medical Center District Hotel Reviews

Drury Plaza Hotel San Antonio Riverwalk

10/10 Excellent

"Love staying here, its in the heart of the Riverwalk, food is amazing here and the customer service is the best in Texas."

Wyndham Garden San Antonio Airport

4/10 Poor

"When we arrived we were put down on the first floor in what they called the overflow area because they were packed even though I booked a few months before hand. It was so hot in the building and when we got to the room, it was hot, smelled like mold and musky. Turn on the lights and half the lights work properly. Very old carpet and furniture. Bathroom wall had mold on it and cleaning was not very good. We had bugs crawling around as well. During the week no housekeeping other than 2 days when I asked for someone to come by, all they did was replace the towels that day. Trash collected outside for days and the gym was so hot it was hard to exercise. Equipment was nice in the gym. They never had washcloths to give to rooms and their laundry area was broke for travelers. They do zero daily housekeeping. Many times there was no hot water and our cards to the door had to be reprogram as well. Great location, beds were very comfortable and staff was friendly. Otherwise very disappointed in everything else."

Frequently asked questions

What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and Cinemark San Antonio 16 while you're in the neighbourhood.

What's a favourite hotel to stay in Medical Center District?

Based on our traveller data, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW is one of the top choices for your stay in Medical Center District. This hotel offers free breakfast and an outdoor pool. Other good options for your stay in the area include San Antonio Marriott Northwest Medical Center and Drury Inn & Suites San Antonio Northwest Medical Center.

How many hotels will I be able to find in Medical Center District?

Expedia has 135 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

USAA Corporate Office Headquarters, Cinemark San Antonio 16 and The San Antonio Art Institute are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.

Hotels in Medical Center District, San Antonio

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Medical Center District hotels

1. San Antonio Marriott Northwest Medical Center

2. Drury Inn & Suites San Antonio Northwest Medical Center

3. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

4. Courtyard by Marriott Medical Center San Antonio

5. Fairfield Inn & Suites by Marriott San Antonio Medical Center

6. OYO Inn & Suites Medical Center San Antonio

7. Park Inn by Radisson

8. Atria Inn & Suites

9. Flex Studios

10. Studio 6 Extended Stay - San Antonio, TX - Medical Center

11. Studio 6 San Antonio, Tx - Northwest Medical Center

12. Country Inn & Suites by Radisson, San Antonio Medical Center, TX

13. Motel 6 San Antonio, TX - Northwest Medical Center

14. Drury Inn & Suites Near La Cantera Parkway

15. La Quinta Inn & Suites by Wyndham San Antonio Northwest

16. Best Western Garden Inn

17. Hampton Inn & Suites Selma-San Antonio-Randolph AFB Texas

18. Extended Stay America Premier Suites - San Antonio - Schertz

19. Spark by Hilton San Antonio Dominion

20. Best Western Plus Downtown North

Compare popular hotels in Medical Center District

Where to stay in Medical Center District

Downtown San Antonio

Far West Side

Uptown

Stone Oak

La Cantera District

Top Medical Center District Hotel Reviews

Drury Plaza Hotel San Antonio Riverwalk

Frequently asked questions

Explore a world of travel with Expedia