Medical Center District
San Antonio
Visit Medical Center District
Stay near popular Medical Center District attractions
Top hotels in Medical Center District
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd San Antonio TX
The price is RM360 per night from 15 Jun to 16 Jun
RM360
RM426 total
15 Jun - 16 Jun
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (3,438 reviews)
"I chose to stay at this Laquinta's location again because it is conveniently close to where I had to do business. The staff are always courteous, helpful and available to assist me to help make my stay more pleasant. The room was clean the breakfast had delicious variety to chose from and the outside ..."
Reviewed on 14 Jun 2026
San Antonio Marriott Northwest Medical Center
3233 NW Loop 410 San Antonio TX
The price is RM410 per night from 11 Jul to 12 Jul
RM410
RM488 total
11 Jul - 12 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy a free local area shuttle, room service and a 24-hour fitness centre. Our guests praise the helpful ...
8.6/10 Excellent! (1,079 reviews)
"No water on the sing no Internet bad service"
Reviewed on 13 Jun 2026
Drury Inn & Suites San Antonio Northwest Medical Center
9806 Interstate Hwy 10 W San Antonio TX
The price is RM365 per night from 7 Jul to 8 Jul
RM365
RM432 total
7 Jul - 8 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,357 reviews)
"Breakfast was incredible.....Only bad thing was only 1 elevator working the whole time I was there (3 days)."
Reviewed on 14 Jun 2026
Drury Plaza Hotel San Antonio Riverwalk
105 S Saint Marys Street San Antonio TX
The price is RM560 per night from 10 Jul to 11 Jul
RM560
RM662 total
10 Jul - 11 Jul
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and 2 hot tubs. Our guests praise the breakfast and the pool in their reviews. ...
9.4/10 Exceptional! (4,749 reviews)
"Great location in downtown with imediate access to Riverwalk. The property is a bit older in a regal historical type of way. Stay was great, the included breakfast a little perk, gym needs a bit of an update, and the valet was a little slow at times but is likely like this thru most high-rise hotels ..."
Reviewed on 13 Jun 2026
Hotel Valencia Riverwalk
150 E Houston St San Antonio TX
The price is RM572 per night from 5 Jul to 6 Jul
RM572
RM792 total
5 Jul - 6 Jul
includes taxes & fees
Stay at this luxury hotel in San Antonio. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff and the clean rooms in ...
9.4/10 Exceptional! (2,834 reviews)
"Housekeeping didn't service the room everyday. Roof leak due to rain and humid hallways could be improved upon. Doorman/Valets were exceptional."
Reviewed on 13 Jun 2026
Riverwalk Plaza
100 Villita Street San Antonio TX
The price is RM362 per night from 21 Jun to 22 Jun
RM362
RM427 total
21 Jun - 22 Jun
includes taxes & fees
Stay at this family-friendly hotel in San Antonio. Enjoy free Wi-Fi, room service and a 24-hour fitness centre. Our guests praise the restaurant and the helpful ...
8/10 Very Good! (6,520 reviews)
"Close to places around the Riverwalk. Restaurant was nice I love the mini taco which I ate twice in a row. So good. The Cafe side was ok wishing they expand the menu to a more breakfast kind not just pastries and coffee. Room was very close to the pool, clean and have toiletries inside the shower ..."
Reviewed on 14 Jun 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Medical Center District
Find the best Medical Center District areas for the activities you enjoy most.
Downtown San Antonio
A scenic riverfront great entertainment and top sights from San Antonio River to Alamodome – discover Downtown San Antonio, a destination also famous for its historic sites.
Far West Side
While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.
Photo by Sarah C.
Open Photo by Sarah C.
Uptown
If you're spending some time in Uptown, San Antonio River and Marion Koogler McNay Art Museum are top sights worth seeing.
Stone Oak
Stone Oak is known for its abundant dining options, and you can plan a trip to Stone Ridge Market and Shops at Hardy Oak while you're in town.
La Cantera District
If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.
