Hotels near Museum of Life and Science

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27 Dec - 28 Dec
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Our top choices for Museum of Life and Science hotels

Lobby
Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85

Hampton Inn & Suites Durham/North I-85
2.5 star property
1.4 km from Museum of Life and Science
9.0 out of 10, Wonderful, (1004)
"Clean rooms and courteous staff."
United States
Katina
The price is RM428
RM486 total
includes taxes & fees
10 Jan - 11 Jan 2026
Hampton Inn & Suites Durham/North I-85
Free buffet breakfast
Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG

Holiday Inn Express Durham by IHG
2.5 star property
2.2 km from Museum of Life and Science
8.8 out of 10, Excellent, (957)
"We arrived at 12:25am. We were welcomed warmly and it was a very nice and pleasant check-in. The staff member that checked us in was so great. "
United States
Timothy
The price is RM393
RM446 total
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express Durham by IHG
Premium bedding, desk, blackout curtains, iron/ironing board
Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University

Comfort Inn & Suites Durham near Duke University
2.5 star property
Croasdaile Farm Master, 3.2 km from Museum of Life and Science
8.6 out of 10, Excellent, (1003)
"Friendly staff, clean room, nice breakfast"
United States
Jessica
The price is RM367
RM416 total
includes taxes & fees
2 Jan - 3 Jan 2026
Comfort Inn & Suites Durham near Duke University
Lobby
Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center

Red Roof Inn Durham - Duke Univ Medical Center
2.0 star property
2.2 km from Museum of Life and Science
6.8 out of 10, (1002)
"Good motel...clean, easy acess "
United States
Howard
The price is RM235
RM273 total
includes taxes & fees
5 Jan - 6 Jan 2026
Red Roof Inn Durham - Duke Univ Medical Center
2 bedrooms
Renovated 2 Bed Walltown Home Walk to Duke A

Renovated 2 Bed Walltown Home Walk to Duke A

Renovated 2 Bed Walltown Home Walk to Duke A
2.0 star property
2.2 km from Museum of Life and Science
The price is RM373
RM845 total
includes taxes & fees
11 Jan - 12 Jan 2026
Renovated 2 Bed Walltown Home Walk to Duke A
Courtyard
Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr

Residence Inn Durham McPherson/Duke University Medical Cntr
3.0 star property
Trinity Park, 3.3 km from Museum of Life and Science
9.2 out of 10, Wonderful, (460)
"Hotel was great - very friendly staff."
United States
Lisa
The price is RM542
RM616 total
includes taxes & fees
26 Jan - 27 Jan 2026
Residence Inn Durham McPherson/Duke University Medical Cntr
Reception
Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center

Hampton Inn & Suites Durham University Medical Center
2.5 star property
4.8 km from Museum of Life and Science
9.6 out of 10, Exceptional, (403)
"Great breakfast, clean rooms and beds "
United States
Fabiola B
The price is RM461
RM523 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hampton Inn & Suites Durham University Medical Center
Meeting facility
Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center

Hilton Garden Inn Durham/University Medical Center
3.0 star property
9th Street District, 3.4 km from Museum of Life and Science
9.2 out of 10, Wonderful, (1000)
"Just right for an overnight business trip "
United States
Cody
The price is RM390
RM442 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton Garden Inn Durham/University Medical Center
Premium bedding, desk, blackout curtains, iron/ironing board
The Durham Hotel

The Durham Hotel

The Durham Hotel
4.0 star property
Downtown Durham, 3.6 km from Museum of Life and Science
9.0 out of 10, Wonderful, (645)
"Great stay. Very nice boutique hotel. "
United States
nadav
The price is RM752
RM854 total
includes taxes & fees
3 Jan - 4 Jan 2026
The Durham Hotel
Terrace/patio
SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View

SpringHill Suites by Marriott Durham City View
3.5 star property
4.6 km from Museum of Life and Science
9.2 out of 10, Wonderful, (456)
"Extremely clean room, nice fragrance throughout the hotel, and friendly staff."
United States
Mary
The price is RM381
RM432 total
includes taxes & fees
4 Jan - 5 Jan 2026
SpringHill Suites by Marriott Durham City View
Property amenity
Aloft Durham Downtown

Aloft Durham Downtown

Aloft Durham Downtown
3.0 star property
American Tobacco District, 4.1 km from Museum of Life and Science
9.0 out of 10, Wonderful, (731)
"Very friendly staff, very clean and convenient location"
United States
Robert
The price is RM753
RM855 total
includes taxes & fees
25 Jan - 26 Jan 2026
Aloft Durham Downtown
BBQ/picnic Area
AC Hotel Durham

AC Hotel Durham

AC Hotel Durham
3.0 star property
4.9 km from Museum of Life and Science
9.2 out of 10, Wonderful, (619)
"Room was very clean, staff very helpful and nice. "
United States
Tia
The price is RM478
RM542 total
includes taxes & fees
4 Jan - 5 Jan 2026
AC Hotel Durham
Daily cooked-to-order breakfast (USD 19.95 per person)
Durham Marriott City Center

Durham Marriott City Center

Durham Marriott City Center
3.5 star property
Downtown Durham, 3.6 km from Museum of Life and Science
8.8 out of 10, Excellent, (824)
"The room was clean. The staff was very helpful and the food was good. "
United States
Tia
The price is RM514
RM584 total
includes taxes & fees
11 Jan - 12 Jan 2026
Durham Marriott City Center
Front of property – evening/night
University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center

University Inn Durham next to Duke University Medical Center
2.0 star property
4 km from Museum of Life and Science
8.8 out of 10, Excellent, (1001)
"Great place"
United States
Chase
The price is RM461
RM523 total
includes taxes & fees
30 Dec - 31 Dec
University Inn Durham next to Duke University Medical Center
Interior entrance
21c Museum Hotel Durham

21c Museum Hotel Durham

21c Museum Hotel Durham
4.0 star property
Downtown Durham, 3.7 km from Museum of Life and Science
8.4 out of 10, Very good, (1000)
"Amazing staff, comfortable rooms, best shower, convenient location. "
United States
Lauren
The price is RM650
RM758 total
includes taxes & fees
17 Jan - 18 Jan 2026
21c Museum Hotel Durham
BBQ/picnic Area
Courtyard Durham Near Duke University/Downtown

Courtyard Durham Near Duke University/Downtown

Courtyard Durham Near Duke University/Downtown
3.0 star property
Croasdaile Farm Master, 3.3 km from Museum of Life and Science
8.2 out of 10, Very good, (1000)
"Great place "
United States
Silvia
The price is RM392
RM445 total
includes taxes & fees
3 Jan - 4 Jan 2026
Courtyard Durham Near Duke University/Downtown
Front of property
The Lodge at Duke Medical Center

The Lodge at Duke Medical Center

The Lodge at Duke Medical Center
3.0 star property
4 km from Museum of Life and Science
8.4 out of 10, Very good, (1002)
"Room was clean and great customer service. "
United States
Anne
The price is RM522
RM592 total
includes taxes & fees
31 Dec - 1 Jan 2026
The Lodge at Duke Medical Center
Exterior
Unscripted Durham, Part of JDV by Hyatt

Unscripted Durham, Part of JDV by Hyatt

Unscripted Durham, Part of JDV by Hyatt
3.5 star property
Downtown Durham, 3.7 km from Museum of Life and Science
8.2 out of 10, Very good, (1002)
"We stay here at least annually and always will. "
United States
Paul
The price is RM514
RM653 total
includes taxes & fees
25 Jan - 26 Jan 2026
Unscripted Durham, Part of JDV by Hyatt
Garden
Arrowhead Inn

Arrowhead Inn

Arrowhead Inn
4.5 star property
9.8 km from Museum of Life and Science
9.8 out of 10, Exceptional, (119)
"Bed was very comfortable, breakfast was yummy, and the surroundings were beautiful"
United States
Ronald
The price is RM794
RM901 total
includes taxes & fees
6 Jan - 7 Jan 2026
Arrowhead Inn
Seasonal outdoor pool, open 9:00 AM to 9:00 PM, pool umbrellas
Hilton Durham near Duke University

Hilton Durham near Duke University

Hilton Durham near Duke University
3.5 star property
5.2 km from Museum of Life and Science
8.4 out of 10, Very good, (1001)
"Great stay"
United States
Daniel
The price is RM395
RM448 total
includes taxes & fees
30 Dec - 31 Dec
Hilton Durham near Duke University
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Museum of Life and Science Hotel Reviews

The Durham Hotel

The Durham Hotel

10/10 Excellent
"Staff was the Best. Housekeeper was so kind and thoughtful."
Edwin 2-night trip
Posted 2 days ago
The Durham Hotel
Durham Marriott City Center

Durham Marriott City Center

10/10 Excellent
"The room was clean. The staff was very helpful and the food was good. "
Tia 1-night trip
Posted 2 months ago
Durham Marriott City Center

Hotels near other Museum of Life and Science attractions

Brightleaf Square

You can do some window-shopping at Brightleaf Square during your visit to Durham. Discover the lively festivals and stunning cathedral in this family-friendly area.
See properties

Vietnam Veterans Living Memorial

You can find out about the history of Durham with a trip to Vietnam Veterans Living Memorial. Attend a sporting event or visit the stunning cathedral in this family-friendly area.
See properties

Frequently asked questions

What's the area like around Museum of Life and Science?
Museum of Life and Science is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, take a look at the 10 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay near Museum of Life and Science?
Hampton Inn & Suites Durham/North I-85 is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. It's located just a short 0.8 mi (1.4 km) from Museum of Life and Science. Other good options within 5 miles include Holiday Inn Express Durham by IHG and Comfort Inn & Suites Durham near Duke University.
How many hotels can I expect to find close to Museum of Life and Science?
Expedia has 10 hotels and other accommodation options within a mile from Museum of Life and Science.
If I need to cancel the hotel reservation for my stay near Museum of Life and Science, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best deals near Museum of Life and Science.
What can I see and do near Museum of Life and Science?
You'll want to browse the exhibits at Nasher Museum of Art at Duke University and Bennett Place. Explore landmarks like American Tobacco Campus, Cameron Indoor Stadium and Wallace Wade Stadium. You can watch performances at Carolina Theatre, Durham Performing Arts Center and Manbites Dog Theater if you're interested in local theatre.