Hotels near Louisville Science Center

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
30 Dec - 31 Dec
Tomorrow
31 Dec - 1 Jan
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Louisville Science Center hotels

View from room
The Grady

The Grady

The Grady
4.0 star property
Downtown Louisville, 0.2 km from Louisville Science Center
9.4 out of 10, Exceptional, (1012)
"Such an amazing hotel...restaurant is delicious! "
United States
Craig
The price is RM587
RM690 total
includes taxes & fees
14 Jan - 15 Jan 2026
The Grady
Exterior
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
4.0 star property
Downtown Louisville, 0.9 km from Louisville Science Center
9.6 out of 10, Exceptional, (429)
"Great location. Great restraunt, great staff. Pleasurable experience!"
United States
Harrison
The price is RM711
RM836 total
includes taxes & fees
18 Jan - 19 Jan 2026
Hotel Distil, Autograph Collection
Street view
Louisville Bourbon Inn

Louisville Bourbon Inn

Louisville Bourbon Inn
5.0 star property
Old Louisville, 2.9 km from Louisville Science Center
10.0 out of 10, Exceptional, (20)
"Great breakfast. Frittata, French toast, eggs, bacon, sausage, grapes, toast, biscuits and gravy - all were excellent. "
United States
Gaven
The price is RM1,073
RM1,245 total
includes taxes & fees
14 Jan - 15 Jan 2026
Louisville Bourbon Inn
Free daily full breakfast
Market Street Inn

Market Street Inn

Market Street Inn
3.5 star property
2.1 km from Louisville Science Center
9.8 out of 10, Exceptional, (120)
"I enjoyed my stay, however the breakfast portion was very small even for a petite person like myself, I was still very hungry after breakfast. There was a cleaning issue with the bathroom that was overlooked by the cleaning staff that I alerted the owners to that will hopefully be fixed for future visitors. The house is great and very clean overall. The owners are very nice."
United States
Megan
The price is RM750
RM848 total
includes taxes & fees
14 Jan - 15 Jan 2026
Market Street Inn
Exterior
Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY
3.0 star property
Downtown Louisville, 0.2 km from Louisville Science Center
9.2 out of 10, Wonderful, (1000)
"Very friendly and clean! Great stay! "
United States
Jackie
The price is RM416
RM489 total
includes taxes & fees
21 Jan - 22 Jan 2026
Homewood Suites by Hilton Louisville Downtown, KY
Dining
Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row
3.0 star property
Downtown Louisville, 1.2 km from Louisville Science Center
9.4 out of 10, Exceptional, (1007)
"The room was perfect and the hotel desk staff was great!"
United States
Ellen
The price is RM425
RM500 total
includes taxes & fees
11 Jan - 12 Jan 2026
Cambria Hotel Louisville Downtown-Whiskey Row
Front of property
21c Museum Hotel Louisville

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville, < 0.1 km from Louisville Science Center
9.2 out of 10, Wonderful, (1001)
"Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!"
United States
Tammy
The price is RM468
RM571 total
includes taxes & fees
2 Jan - 3 Jan 2026
21c Museum Hotel Louisville
Lobby
The Brown Hotel

The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville, 1.2 km from Louisville Science Center
9.4 out of 10, Exceptional, (1164)
"Fantastic place to stay in Louisville."
United States
Nathaniel
The Brown Hotel
Front of property
DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast
3.0 star property
Old Louisville, 2.8 km from Louisville Science Center
9.8 out of 10, Exceptional, (98)
"Breakfast was wonderful, great place to stay!"
United States
Janie
The price is RM580
RM673 total
includes taxes & fees
4 Jan - 5 Jan 2026
DuPont Mansion Bed & Breakfast
Lobby
Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown
3.0 star property
Downtown Louisville, 0.3 km from Louisville Science Center
9.2 out of 10, Wonderful, (518)
"Accommodations were perfect. Staff excellent. Food was very good."
United States
Bennett
The price is RM394
RM463 total
includes taxes & fees
15 Jan - 16 Jan 2026
Towneplace Suites By Marriott Louisville Downtown
Premium bedding, down duvets, memory-foam beds, individually furnished
Stellar Suites

Stellar Suites

Stellar Suites
4.5 star property
East Market District, 2.2 km from Louisville Science Center
9.6 out of 10, Exceptional, (117)
"Clean and great location "
United States
Greg
The price is RM478
RM766 total
includes taxes & fees
14 Jan - 15 Jan 2026
Stellar Suites
Sauna, body treatments, aromatherapy, hot stone massages
Omni Louisville Hotel

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville, 0.8 km from Louisville Science Center
9.2 out of 10, Wonderful, (1745)
"This is a beautiful hotel in a great location. Very kind staff and helpful with directions."
United States
Bonnie
The price is RM679
RM798 total
includes taxes & fees
1 Jan - 2 Jan 2026
Omni Louisville Hotel
Bar (on property)
Moxy Louisville Downtown

Moxy Louisville Downtown

Moxy Louisville Downtown
3.5 star property
Downtown Louisville, 0.9 km from Louisville Science Center
9.2 out of 10, Wonderful, (702)
"Awesome location and the staff was super friendly"
United States
Kelly
The price is RM422
RM497 total
includes taxes & fees
10 Jan - 11 Jan 2026
Moxy Louisville Downtown
2 restaurants, breakfast served
Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
3.5 star property
Phoenix Hill, 2.1 km from Louisville Science Center
9.4 out of 10, Exceptional, (842)
"Courteous staff and the bed was very comfy."
United States
Daniel
The price is RM416
RM490 total
includes taxes & fees
15 Jan - 16 Jan 2026
Tempo By Hilton Louisville Downtown Nulu
4 restaurants, breakfast, lunch, dinner served; American cuisine
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville, 0.5 km from Louisville Science Center
9.0 out of 10, Wonderful, (3909)
"Great place to stay! "
United States
Rochelle
The price is RM541
RM637 total
includes taxes & fees
5 Jan - 6 Jan 2026
Galt House Hotel Trademark Collection by Wyndham
Exterior
Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG
2.5 star property
Downtown Louisville, 0.2 km from Louisville Science Center
8.8 out of 10, Excellent, (1668)
"very clean throughout, helpful staff,very nice breakfast"
United States
Wayne
The price is RM333
RM392 total
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express & Suites Louisville Downtown by IHG
View from room
Aloft Louisville Downtown

Aloft Louisville Downtown

Aloft Louisville Downtown
3.0 star property
Downtown Louisville, 0.9 km from Louisville Science Center
9.0 out of 10, Wonderful, (1000)
"Great room and location."
Canada
Rene
The price is RM408
RM480 total
includes taxes & fees
25 Jan - 26 Jan 2026
Aloft Louisville Downtown
Hypo-allergenic bedding, in-room safe, desk, laptop workspace
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
4.0 star property
East Market District, 2.1 km from Louisville Science Center
9.2 out of 10, Wonderful, (1021)
"Great location and accommodations."
United States
Steve
The price is RM515
RM606 total
includes taxes & fees
6 Jan - 7 Jan 2026
Hotel Genevieve part of JdV by Hyatt
Property amenity
AC Hotel Louisville Downtown

AC Hotel Louisville Downtown

AC Hotel Louisville Downtown
3.5 star property
East Market District, 2.1 km from Louisville Science Center
9.2 out of 10, Wonderful, (611)
"Everything was amazing, staff was wonderful "
United States
Ashley
The price is RM447
RM526 total
includes taxes & fees
9 Jan - 10 Jan 2026
AC Hotel Louisville Downtown
Exterior
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
4.0 star property
Downtown Louisville, 0.8 km from Louisville Science Center
9.0 out of 10, Wonderful, (59)
"Amazing property! Best hotel in Louisville! Will be staying there again!"
United States
Norman
The price is RM683
RM804 total
includes taxes & fees
7 Jan - 8 Jan 2026
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Louisville Science Center Hotel Reviews

The Grady

The Grady

10/10 Excellent
"Great and welcoming place to stay. from the Front Desk staff to the servers at the Wild Swan. We Loved staying there! Will be back again!❤️"
Beth 1-night trip
Posted 2 days ago
The Grady

Hotels near other Louisville Science Center attractions

Exploration of Louisville Slugger Museum in Downtown Louisville, Kentucky on a Sunny Day

Louisville Slugger Museum

4.5/5 (1,200 reviews)
Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.
See properties
A great stop! This has to be one of the best museums I’ve been about somebody! Great stop and a fantastic life!
Photo by Corey Dargan
Open Photo by Corey Dargan

Muhammad Ali Center

4.3/5 (298 reviews)
One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.
See properties

Frequently asked questions

What's the area like around Louisville Science Center?
Louisville Science Center is located in an area of Louisville known for its stunning river views, sporting events and great live music scene. If you're looking for a convenient place to stay, take a look at the 294 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay near Louisville Science Center?
Adjacent to Louisville Science Center, Holiday Inn Express & Suites Louisville Downtown by IHG is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and a 24-hour fitness centre. Other good choices within a short distance include Galt House Hotel Trademark Collection by Wyndham and Omni Louisville Hotel.
How many hotels can I expect to find close to Louisville Science Center?
Expedia has 294 hotels and other accommodation options within a mile from Louisville Science Center.
If I need to cancel the hotel reservation for my stay near Louisville Science Center, will I receive a refund?
Yes! Most hotel room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the filter option "fully refundable" to get the top deals on offer near Louisville Science Center.
What can I see and do near Louisville Science Center?
21c Museum Hotel, Louisville Slugger Museum and Muhammad Ali Center feature a variety of fascinating exhibits to see while you're in town. Explore landmarks like Belle of Louisville, Whiskey Row and Big Four Bridge. You can catch a show at Kentucky Center for the Performing Arts, Louisville Palace and Derby Dinner Playhouse.