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Hotels near Florida Keys National Marine Sanctuary

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Check prices for these dates

Tonight
16 Oct - 17 Oct
Tomorrow
17 Oct - 18 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.
A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.
A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.
A swimming pool with lounge chairs, surrounded by palm trees and greenery.

1. Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
United States
John
RM1,135
RM1,277 total
includes taxes & fees
27 Oct - 28 Oct
Almond Tree Inn Hotel - Adults Only
A tropical outdoor area with palm trees, hanging plants, and string lights.
An outdoor patio with a table and chairs, surrounded by lush greenery and string lights.
A wooden deck with lush greenery and a pool area.
A large, two-story building with a balcony, surrounded by dense tropical foliage.

2. Douglas House - Adults Only

Douglas House - Adults Only
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
United States
Maricela
RM642
RM795 total
includes taxes & fees
19 Oct - 20 Oct
Douglas House - Adults Only
A modern interior with a staircase, a sofa set, a wooden table, and a television.
A spacious room with a large bed, a sofa, a chair, a small table, and a television.
A courtyard with two green lounge chairs, a palm tree, and a building with a white facade and lattice window design.
A pool area with a clear view of a house in the background, surrounded by palm trees and greenery.

3. Simonton Court Historic Inn & Cottages

Simonton Court Historic Inn & Cottages
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
United States
William
RM690
RM776 total
includes taxes & fees
25 Oct - 26 Oct
Simonton Court Historic Inn & Cottages
A modern outdoor area with a pool, lounge chairs, and a bar area.
A modern hotel with a prominent glass facade, palm trees, and a clear sky.
A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.
A modern hotel room with a bed, sofa, coffee table, and artwork.

4. H2O Suites - Adults Only

H2O Suites - Adults Only
Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary
United States
Carmen
RM1,343
RM1,786 total
includes taxes & fees
26 Oct - 27 Oct
H2O Suites - Adults Only
A pool area with lounge chairs and a table, surrounded by palm trees.
A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.
A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.
A neon sign for Orchid Key Inn with a 'VACANCY' sign below it.

5. Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
United States
ben
RM1,037
RM1,167 total
includes taxes & fees
27 Oct - 28 Oct
Orchid Key Inn - Adults Only
A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.
A colonial-style building with a porch, surrounded by lush tropical vegetation.
A bar area with a counter, chairs, and a clock.
A couple walking along a poolside pathway surrounded by lush greenery.

6. The Gardens Hotel

The Gardens Hotel
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
United States
Gisele
RM1,373
RM1,545 total
includes taxes & fees
27 Oct - 28 Oct
The Gardens Hotel
A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.
A row of blue bicycles parked under a tree, with a white fence and a building in the background.
A two-story building with a porch, a sign reading "The Grand Guesthouse," and a purple flag.
A bedroom with a bed, nightstand, lamp, air conditioning unit, and a no smoking sign.

7. The Grand Guesthouse

The Grand Guesthouse
Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary
United States
Justyn
RM642
RM825 total
includes taxes & fees
27 Oct - 28 Oct
The Grand Guesthouse
A pool area with lounge chairs and palm trees.
A neatly made bed with patterned pillows, a bedside table with a bottle and glasses, and a window with orchids.
A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.
A sign for Santa Maria Resort surrounded by lush greenery and palm trees.

8. Santa Maria Suites

Santa Maria Suites
Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary
United States
Anthony
RM1,220
RM1,649 total
includes taxes & fees
26 Oct - 27 Oct
Santa Maria Suites
A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.
A covered walkway with a wooden ceiling, white railings, and a brick path.
A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.
A pool area with lounge chairs and a wooden building with balconies.

9. Island City House Hotel

Island City House Hotel
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
United States
Elise
RM911
RM1,025 total
includes taxes & fees
25 Oct - 26 Oct
Island City House Hotel
A large, ornate hotel with a pool, palm trees, and a view of the ocean.
A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.
A grand staircase with ornate railings and a chandelier.
A balcony with white railings and a table, overlooking a beach with palm trees and a clear blue sky.

10. Southernmost House - Adult Exclusive

Southernmost House - Adult Exclusive
Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary
United States
Amy
RM731
RM1,339 total
includes taxes & fees
25 Oct - 26 Oct
Southernmost House - Adult Exclusive
A swimming pool with water splashing, surrounded by palm trees and a building in the background.
A hotel with a pool, bicycles, and lush greenery.
The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.
The exterior of the Silver Palms Inn with a two-story structure, a green awning over the entrance, and a palm tree to the right.

11. Silver Palms Inn & Historic Homes

Silver Palms Inn & Historic Homes
Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary
United States
sam
RM364
RM685 total
includes taxes & fees
25 Oct - 26 Oct
Silver Palms Inn & Historic Homes
A reception area with a curved marble counter, ceiling fans, large windows, and a staircase.
A bedroom with a bed, two bedside lamps, a ceiling fan, and a view of a balcony with plants.
A breakfast table with a variety of food items, including fruits, pastries, and a coffee mug.
A two-story house with a white exterior, a green roof, and a staircase leading to the upper floor.

12. Westwinds Inn

Westwinds Inn
Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary
United States
Anthony
RM661
RM744 total
includes taxes & fees
25 Oct - 26 Oct
Westwinds Inn
A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.
A cozy living room with a wooden ceiling, a sofa set, two side tables with lamps, and framed artwork on the wall.
A wicker outdoor seating area with two chairs and a table, surrounded by lush tropical foliage.
A hotel room with a bed, a nightstand, a chair, a small table, and a ceiling fan.

13. Ambrosia Key West

Ambrosia Key West
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
United States
RICHARD
RM935
RM1,052 total
includes taxes & fees
26 Oct - 27 Oct
Ambrosia Key West
A gated entrance with lush green foliage and a white picket fence.
A hotel room with a large bed, two bedside tables, a ceiling fan, and two framed pictures on the wall.
A swimming pool with lounge chairs, a covered deck, and a view of lush greenery.
A white colonial-style building with a balcony, surrounded by palm trees and a white picket fence.

14. Coco Plum Inn

Coco Plum Inn
Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary
United States
Riley
RM817
RM920 total
includes taxes & fees
18 Oct - 19 Oct
Coco Plum Inn
A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.
A yellow building with a door marked '7'.
A room with a bed, a desk, a chair, a lamp, a painting of a boat on water, and a view of the sea.
A garden with a stone pathway, a wooden fence, and various tropical plants.

15. Alexander Palms Court

Alexander Palms Court
Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary
United States
Andrew
RM918
RM1,033 total
includes taxes & fees
19 Oct - 20 Oct
Alexander Palms Court
A hotel with a covered entrance, multiple balconies, and palm trees.
A room with a stone wall, a wooden bench, a cactus, and a framed painting.
A restaurant interior with wooden beams, a bar area, and a colorful ceiling mural.
A covered balcony with white Adirondack chairs and a small table with flowers, overlooking a turquoise sea and distant shoreline.

16. Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West
Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary
United States
Susan
RM1,057
RM1,350 total
includes taxes & fees
18 Oct - 19 Oct
Opal Key Resort & Marina, Key West
Lobby
Exterior
A two-story building with a balcony, a flag, and a palm tree.
A covered outdoor area with a pool, wicker furniture, and a red umbrella.

17. The Independent Inn-Adults only

The Independent Inn-Adults only
Historic Seaport, 1.6 km from Florida Keys National Marine Sanctuary
United States
Michael
RM473
RM669 total
includes taxes & fees
18 Oct - 19 Oct
The Independent Inn-Adults only
A building with a white exterior, a large red awning, and a gated entrance.
A paved pathway lined with various plants and trees, leading to a building with a beige exterior.
A spacious kitchen with a dining area, large windows, and a view of the outdoors.
A pool area with lounge chairs and a lifebuoy.

18. Authors of Key West Guest House

Authors of Key West Guest House
The Meadows, 1.8 km from Florida Keys National Marine Sanctuary
United States
Robbie
RM621
RM698 total
includes taxes & fees
27 Oct - 28 Oct
Authors of Key West Guest House
A large, white, two-story building with a balcony and a sign reading "The Marker Resort."
A tropical setting with palm trees and a building with a white facade and dark roof.
A resort with a swimming pool, lounge chairs, umbrellas, and palm trees.
A marina with various boats docked, including a green and white boat named 'Jolly Roger'.

19. The Marker Key West Harbor Resort

The Marker Key West Harbor Resort
Historic Seaport, 1.3 km from Florida Keys National Marine Sanctuary
United States
Lynne
RM769
RM1,122 total
includes taxes & fees
25 Oct - 26 Oct
The Marker Key West Harbor Resort
A pool area with lounge chairs and a cabana.
A dining area with a glass table, clear glass bottles, a bowl of fruit, and a wicker chair.
A waterfront hotel with a long pier, multiple balconies, and a view of the ocean.
A hotel room with a bed, a sofa, a desk with a computer, a chair, and a view of the sea through large windows.

20. Ocean Key Resort - A Noble House Resort

Ocean Key Resort - A Noble House Resort
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
United States
Patrick
RM1,141
RM1,615 total
includes taxes & fees
29 Oct - 30 Oct
Ocean Key Resort - A Noble House Resort
View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.
Almond Tree Inn Hotel - Adults Only
10.0
Exceptional
1,001 reviews
View
A tropical outdoor area with palm trees, hanging plants, and string lights.
Douglas House - Adults Only
9.8
Exceptional
557 reviews
View
A modern interior with a staircase, a sofa set, a wooden table, and a television.
Simonton Court Historic Inn & Cottages
9.8
Exceptional
1,003 reviews
View
A modern outdoor area with a pool, lounge chairs, and a bar area.
H2O Suites - Adults Only
9.8
Exceptional
667 reviews
View
A pool area with lounge chairs and a table, surrounded by palm trees.
Orchid Key Inn - Adults Only
9.8
Exceptional
1,000 reviews
View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

10/10 Excellent
"No tap beer at all but other than that it was great"
Holly 5-night trip
Posted less than an hour ago
Southernmost Beach Resort and Guesthouses
La Concha Key West, Autograph Collection

La Concha Key West, Autograph Collection

10/10 Excellent
"Loved our stay at La Concha. Staff was excellent and constantly focused on our comfort and enjoyment. Upon arrival (kind of late), we were unsure if the bar was still serving food. Once staff became aware that we wanted food, they did everything they could think of to ensure we got what we needed. Top-notch customer service! The location of the hotel could not be beat, for our purposes. Easy to explore many different areas that we wanted to see…particularly Old Town and the seaport district. Everything is very walkable; however, if you have people in your party who cannot walk much distance, it is very easy to rent a golf cart to haul them around. An extremely enjoyable trip, made all the better by the staff and quality of La Concha."
LEE 7-night trip
Posted 2 hours ago
La Concha Key West, Autograph Collection
Pier House Resort & Spa

Pier House Resort & Spa

10/10 Excellent
"The perfect place to stay! Quiet, great soft music at the outside bar that we could hear on the private beach. Close to everything. Helpful staff. Only thing is it’s very expensive."
Lisa 6-night trip
Posted 5 hours ago
Pier House Resort & Spa
Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West

10/10 Excellent
"The hotel location, cleanliness and view are awesome. No complaints about anything. The unlimited cold water bottles were icing on the cake. If I’m so happy with a partial sea view room, I’ll be even happier with an oceanfront room. Maybe next time."
Vivek 2-night trip
Posted 6 hours ago
Opal Key Resort & Marina, Key West
Casa Marina Key West, Curio Collection by Hilton

Casa Marina Key West, Curio Collection by Hilton

10/10 Excellent
"Great property"
Charlene 3-night trip
Posted 1 day ago
Casa Marina Key West, Curio Collection by Hilton
Wicker Guesthouse

Wicker Guesthouse

10/10 Excellent
"Location was great"
Kathy 2-night trip
Posted 1 day ago
Wicker Guesthouse
Douglas House - Adults Only

Douglas House - Adults Only

10/10 Excellent
"Great quiet place with great amenities pool beverages whatever you may need"
Theresa 3-night trip
Posted 2 days ago
Douglas House - Adults Only
Paradise Inn Key West - Adults Only

Paradise Inn Key West - Adults Only

10/10 Excellent
"Place was great, clean, and reasonable. Beware the roosters at 6am but that might be the entire city of Key West Old Town"
Jason 2-night trip
Posted 3 days ago
Paradise Inn Key West - Adults Only
Weatherstation Inn

Weatherstation Inn

10/10 Excellent
"We liked how close the Inn was to everything we wanted to do. Very walkable and in a quiet area. Staff was friendly, the breakfast bake goods were great."
Sarah 2-night trip
Posted 6 days ago
Weatherstation Inn

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)
The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.
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A wooden signpost with directional arrows pointing to various cities and their distances.
Photo by Martin Pettersson

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.
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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)
You can learn about the history of Key West with a trip to Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.
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Coffee Butler Amphitheater

You can make plans for a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.
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USCGC Ingham Maritime Museum

You can spend an afternoon browsing the exhibits at USCGC Ingham Maritime Museum during your trip to Key West.
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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.
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We Cycle Key West

You can do some window-shopping at We Cycle Key West during your stay in Key West.
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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1487 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Florida Keys National Marine Sanctuary?
Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveller data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.
How many hotels will I find near Florida Keys National Marine Sanctuary?
Expedia has 1487 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater and Key West Film Society if you're interested in local theatre.