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Best Luxury Hotels in Upstate South Carolina

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Check availability on Upstate South Carolina Luxury Hotels

Our top choices for Upstate South Carolina luxury hotels

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Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (418)
"Absolutely one of the best hotels to stay at. "
United States
stephen
The price is RM1,182
RM1,336 total
includes taxes & fees
4 Jan - 5 Jan 2026
Grand Bohemian Lodge Greenville, Autograph Collection
Meeting facility
The Westin Poinsett Greenville

The Westin Poinsett Greenville

4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (1003)
"Awesome place "
United States
Dominick
The price is RM696
RM765 total
includes taxes & fees
14 Dec - 15 Dec
The Westin Poinsett Greenville
Restaurant
Hotel Hartness

Hotel Hartness

4.0 star property
Greenville
9.8 out of 10, Exceptional, (624)
"Beautiful location, friendly staff"
United States
Andrew
The price is RM623
RM824 total
includes taxes & fees
15 Dec - 16 Dec
Hotel Hartness
In-room safe, blackout curtains, soundproofing, iron/ironing board
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4.0 star property
Clemson
9.8 out of 10, Exceptional, (739)
"Staff was amazing and our room was clean and comfortable. "
United States
Amanda R
The price is RM696
RM772 total
includes taxes & fees
11 Dec - 12 Dec
The Shepherd Hotel Downtown Clemson
Meeting facility
The Abernathy of Clemson

The Abernathy of Clemson

4.0 star property
Clemson
9.6 out of 10, Exceptional, (555)
"location is amazing! "
United States
colleen
The Abernathy of Clemson
Restaurant
Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast

4.0 star property
Pendleton
10.0 out of 10, Exceptional, (78)
"The owners are amazing. Comfy rooms, stellar breakfast and good people. "
United States
Renee
The price is RM518
RM781 total
includes taxes & fees
12 Dec - 13 Dec
Liberty Hall Bed and Breakfast
Premium bedding, down duvets, pillow-top beds, in-room safe
Greenville Marriott

Greenville Marriott

4.0 star property
Greenville
8.6 out of 10, Excellent, (608)
"Front desk was so pleasant and helpful! Rooms were clean. Housekeeping was great too!"
United States
Kimberlee
The price is RM395
RM435 total
includes taxes & fees
19 Dec - 20 Dec
Greenville Marriott
Laptop workspace, iron/ironing board, free WiFi, bed sheets
Mint House Greenville - Downtown

Mint House Greenville - Downtown

4.0 star property
Greenville Downtown
9.2 out of 10, Wonderful, (772)
"Excellent stay as always! "
United States
Elena
The price is RM441
RM499 total
includes taxes & fees
4 Jan - 5 Jan 2026
Mint House Greenville - Downtown
Bar (on property)
Hotel Domestique

Hotel Domestique

4.0 star property
Travelers Rest
9.6 out of 10, Exceptional, (30)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is RM1,133
RM1,246 total
includes taxes & fees
8 Jan - 9 Jan 2026
Hotel Domestique
Terrace/patio
The Station by Compo Hotels

The Station by Compo Hotels

4.0 star property
Travelers Rest
10.0 out of 10, Exceptional, (15)
"great place perfect for more privacy vs. a standard hotel"
United States
John
The price is RM812
RM1,233 total
includes taxes & fees
5 Jan - 6 Jan 2026
The Station by Compo Hotels
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Upstate South Carolina Hotel Reviews

Hilton Greenville

Hilton Greenville

10/10 Excellent
"Amazing staff and clean room"
Kelli 1-night trip
Posted 3 days ago
Hilton Greenville

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