A calm lake reflecting trees with autumn foliage, a clear sky, and a distant shoreline.

St. Charles Spa Hotels

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Check availability on St. Charles Hotels with Spa

Tonight
2 Oct - 3 Oct
Tomorrow
3 Oct - 4 Oct
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

Our top choices for St. Charles hotels with a spa

A modern spa with a curved reception desk, a large mirror, and a decorative water feature.
An indoor swimming pool with clear glass walls, metal railings, and a tiled floor.
A modern tavern with a large sign, glass doors, and indoor seating visible through the windows.
A bakery display case with various pastries and cakes.

1. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
St. Charles
  • Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
RM691
RM875 total
includes taxes & fees
12 Oct - 13 Oct
Ameristar Casino Resort and Spa
A reception desk with a wooden finish and the name "IDOL WOLF" on it.
A modern bathroom with a bathtub, a vanity with a mirror, and a shower area.
A spacious lobby with a large spherical sculpture, a seating area, and a view of the outside through a large window.
A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.

2. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
Downtown West
  • Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
RM559
RM674 total
includes taxes & fees
18 Oct - 19 Oct
21C Museum Hotel St Louis
A bathroom with a white sink, dark wooden door, and a shower area with striped glass walls.
A modern interior with a staircase, a large abstract painting, and a seating area with a glass coffee table.
A room with a green armchair, a round table, a lamp, and a mirror on the wall.
A two-story building with a dark entrance, large windows, and a brick facade.

3. Truitt Hotel

Truitt Hotel
Lafayette Square
RM691
RM839 total
includes taxes & fees
18 Oct - 19 Oct
Truitt Hotel
A couple relaxing by a window overlooking a bridge and water.
A bar area with a bartender, a bar counter with various bottles, and a view of the Gateway Arch.
A modern dining area with a long table set for a meal, large windows offering a view of a bridge, and a stone accent wall.
A room with large windows overlooking a bridge and water, featuring wooden chairs and a small table.

4. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
Downtown St. Louis
  • Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
RM1,530
RM1,789 total
includes taxes & fees
15 Oct - 16 Oct
Four Seasons Hotel St Louis
A modern kitchen with wooden cabinets, a central island, and framed artwork on the walls.
An indoor dining area with a long table, chairs, hanging plants, and a view of a brick building through large windows.
An outdoor seating area with modern furniture, a bar, and large windows offering views of a cityscape.
A bar area with leather seating, a bar counter, and shelves of bottles.

5. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
Clayton
  • Revel in a rejuvenating spa retreat with aromatherapy treatments and hot stone massages at this luxury St. Louis hotel.
RM2,365
RM2,761 total
includes taxes & fees
1 Nov - 2 Nov
The Ritz-Carlton, St. Louis
View all properties

Choose what matters most at spa hotels in St. Charles

Pool
Hot tub
Breakfast included
4 stars
5 stars

Top St. Charles Hotel Reviews

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles

10/10 Excellent
"We stayed at this hotel several times over the years and they never disappoint! Rooms are in very good condition and clean. Staff is pleasant and professional. The breakfast and late afternoon food and drinks are wonderful options to start and end the day. The location is very walkable to shopping and eating."
Kevin J 2-night trip
Posted 4 hours ago
Drury Plaza Hotel St. Louis St. Charles
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

8/10 Good
"Location of hotel was perfect since I was attending soccer game which stadium was across the street"
Joseph 2-night trip
Posted 6 hours ago
Pear Tree Inn St. Louis Near Union Station
Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent
"We have always enjoyed the Drury Inn group, but this facility was exceptional. It is a historical building, a former YMCA for railroad workers, and very well preserved. They serve a nice breakfast as well as a delicious dinner buffet with a complimentary social hour. The staff is friendly and helpful. I also appreciate the secure parking garage. Close proximity to Union Station, Energizer Park for soccer, and a short drive to Busch Stadium and the Gateway Arch. Highly recommend!"
Larry 2-night trip
Posted 19 hours ago
Drury Plaza Hotel St. Louis Union Station
Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles

10/10 Excellent
"I stayed in St Charles Missouri and Geneva was awesome she was at the front desk during check-in and she was great"
Latanya 1-night trip
Posted 1 day ago
Embassy Suites by Hilton St. Louis St. Charles
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent
"Very happy with our stay. Everyone was so friendly and helpful. Room was great and the food was good"
Patrick D. 1-night trip
Posted 2 days ago
Drury Plaza Hotel St. Louis at the Arch

Frequently asked questions

Looking for a spa hotel in St. Charles?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travellers highly recommend the restaurants in St. Charles. Enjoy the historical sites and riverfront during your holiday. Hotels with spas are a great way to break away from your daily routine and add a layer of luxury to your stay.
What is the best spa hotel in St. Charles?
Ameristar Casino Resort and Spa is a top luxury spa hotel featuring 6 restaurants, a casino, a 24-hour fitness centre and an outdoor pool. Treat yourself to a facial, body scrub or hydrotherapy at Ara.
How many spa hotels will I find in St. Charles?
Among Expedia's 178 accommodation options in St. Charles, there is 1 spa hotel.
What's there to see and do in St. Charles?
Experience all that St. Charles has to offer when you visit Historic Main Street, Katy Trail and Lewis & Clark Boathouse and Nature Center. If you have some spare time during your trip, you might want to check out St Charles Convention Center and Ameristar Casino St. Charles.
What is a St. Charles spa hotel?
Spa hotels in St. Charles provide lodging and have a full on-site spa which offers services such as couples massages as well as body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on holiday.

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