Santa Clara Vacation Rentals

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Check prices for these dates

In two weeks
2 Jan - 4 Jan
In two months
13 Feb - 15 Feb
In three months
13 Mar - 15 Mar
In four months
10 Apr - 12 Apr

Our top choices for Santa Clara holiday rentals

50-inch LED TV with satellite channels
Arcadia Condo Suites

Aparthotel in Costa del Este

Arcadia Condo Suites
2.5 star property
9.4 out of 10, Exceptional, (163)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
The price is RM293
RM511 total
includes taxes & fees
3 Jan - 4 Jan 2026
Arcadia Condo Suites
Private beach
Habitación Privada en Playa Dorada + Kitchenette

Villa in Vacamonte

Habitación Privada en Playa Dorada + Kitchenette
3.0 star property
The price is RM88
RM136 total
includes taxes & fees
23 Dec - 24 Dec
Habitación Privada en Playa Dorada + Kitchenette
Interior detail
La Isabela Suites

Aparthotel in Casco Viejo

La Isabela Suites
3.5 star property
10.0 out of 10, Exceptional, (171)
"Wonderful charming property in the heart of the historic district. "
United States
Angela
La Isabela Suites
Restaurant
Las Clementinas

Aparthotel in Casco Viejo

Las Clementinas
3.5 star property
9.4 out of 10, Exceptional, (171)
"The front desk receptionist was extremely helpful! The room was clean and comfortable! We would definitely stay again!"
United States
april
The price is RM670
RM737 total
includes taxes & fees
24 Dec - 25 Dec
Las Clementinas
Exterior
Yoo Panamá by Boutique Apartments

Apartment in Bella Vista

Yoo Panamá by Boutique Apartments
3.5 star property
8.2 out of 10, Very good, (49)
"Nice view & very clean"
United States
Latricia
The price is RM141
RM721 total
includes taxes & fees
23 Dec - 24 Dec
Yoo Panamá by Boutique Apartments
Outdoor pool, free pool cabanas, pool loungers
Yoo Panama & Arts Tower

Apartment in Bella Vista

Yoo Panama & Arts Tower
3.0 star property
9.4 out of 10, Exceptional, (50)
"Nice stay"
United States
ANGEL
Yoo Panama & Arts Tower
Outdoor pool
Wanders Panama by Boutique Apartments

Apartment in San Francisco

Wanders Panama by Boutique Apartments
4.0 star property
10.0 out of 10, Exceptional, (1)
"I will go again thank you so much"
United States
GISY ITZEL
The price is RM671
RM1,361 total
includes taxes & fees
5 Jan - 6 Jan 2026
Wanders Panama by Boutique Apartments
Free WiFi, bed sheets
La Palma Aparta Suite

Apartment in Amador

La Palma Aparta Suite
3.0 star property
The price is RM193
RM335 total
includes taxes & fees
23 Dec - 24 Dec
La Palma Aparta Suite
Reception
Torres de Alba Hotel & Suites

Aparthotel in Bella Vista

Torres de Alba Hotel & Suites
3.5 star property
8.8 out of 10, Excellent, (483)
"The buffet bar and great customer service. "
United States
Kayhiuska
Torres de Alba Hotel & Suites
Outdoor pool
Boutique Apartments Panama

Apartment in Bella Vista

Boutique Apartments Panama
3.5 star property
7.6 out of 10, Good, (221)
"The view was amazing and the place was great could stay here again "
United States
Yonnette
Boutique Apartments Panama
Outdoor pool
Boutique Apartments Atlapa

Apartment in San Francisco

Boutique Apartments Atlapa
3.0 star property
7.8 out of 10, Good, (27)
"I had an excellent stay here ! It was a very amazing the host is an amazing person thank you for making My stay great❤️"
United States
Shamia
Boutique Apartments Atlapa
Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas, pool loungers
Casco View Apartments

Condo in Santa Ana

Casco View Apartments
3.5 star property
9.2 out of 10, Wonderful, (55)
"We live this property and stay here whenever we are in town."
United States
chris
Casco View Apartments
Balcony
San Francisco by Wynwood House

Apartment in San Francisco

San Francisco by Wynwood House
3.0 star property
9.2 out of 10, Wonderful, (56)
"Clean and walkable location"
United States
Tamera
The price is RM642
RM808 total
includes taxes & fees
11 Jan - 12 Jan 2026
San Francisco by Wynwood House
Living area
Centriqo by Wynwood house

Apartment in Veracruz

Centriqo by Wynwood house
3.0 star property
The price is RM668
RM869 total
includes taxes & fees
19 Jan - 20 Jan 2026
Centriqo by Wynwood house
Property grounds
Swette Love 10 Minutes From the Airport Tocumen

Apartment in Las Mañanitas

Swette Love 10 Minutes From the Airport Tocumen
2.0 star property
The price is RM310
RM389 total
includes taxes & fees
25 Dec - 26 Dec
Swette Love 10 Minutes From the Airport Tocumen
Living area
Living 73 Panamá by Boutique Apartments

Apartment in San Francisco

Living 73 Panamá by Boutique Apartments
3.0 star property
The price is RM102
RM704 total
includes taxes & fees
23 Dec - 24 Dec
Living 73 Panamá by Boutique Apartments
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Clara Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"Staff, amenities, clean room"
Randall Barboza 1-night trip
Posted 6 hours ago
Hotel Riu Plaza Panama

Find out more about Santa Clara

Search for holiday rentals in Santa Clara on Expedia.co.uk! You can easily find your home rentals, villas, holiday apartments in Santa Clara using one of the methods below:

  • View our selection of featured holiday rentals in Santa Clara
  • Use the map to find apartments and other holiday homes in the Santa Clara neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Clara while they last

Look no further and take a look at our great range of rental properties in Santa Clara!

Frequently asked questions

Can I find holiday rentals in Santa Clara?

Yes, there are holiday rentals close to the most popular sights in Santa Clara, or you can select a more secluded option if you're looking for a relaxing stay. Santa Clara is known for its monuments.

What can I see and do in Santa Clara?

While exploring the area, visit family-friendly sights like Summit Botanical Gardens & Zoo, or get outside and enjoy nature at Culebra Cut. In the wider area, you’ll find Albrook Shopping Mall and Gamboa Rainforest Resort.

What are holiday rentals like in Santa Clara?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in Santa Clara. Holiday rentals offer extras like laundry facilities and kitchens so you'll have all the comforts of home. If you're concerned about cleanliness, holiday rentals can provide a sense of privacy away from shared hotel lifts and busy lobbies while still allowing you to travel. You'll also have more space in a holiday rental than in a standard hotel, which makes a holiday rental a popular option for a family trip or a small group gathering.