Otay Mesa
San Diego


Visit Otay Mesa
Popular places to visit

San Diego Zoo
One of the largest zoos in America housing around 4000 creatures, San Diego Zoo offers an enchanting and educational experience for visitors of all ages.

San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices.

SeaWorld
A fun family favourite, where you can get up close to the local marine life, enjoy fun rides and be wowed by the performances.

Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Balboa Park
One of America’s largest urban green spaces, Balboa Park is an exciting spot packed with art, culture, and a world-renowned zoo.

Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Things to do

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Crossing Borders: Tijuana Day Trip from San Diego

Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego

From Tijuana: Valle de Guadalupe Private Winery Tour
Top hotels in Otay Mesa

Hard Rock Hotel San Diego
Clean room
Reviewed on 20 Jan 2026

The DEXTRO Little Italy, BW Premier Collection
Great hotel! Great staff! Great location!
Reviewed on 22 Jan 2026

Sheraton San Diego Resort
I stayed in one of the newly-remodeled rooms overlooking the pool/bay in the Marina Tower. Really lovely and the room was exceptionally well-appointed. Great view! The staff was also accomodating with arranging a day-rate for use of the room since I wasn't flying out until the evening. Would absolutely ...
Reviewed on 19 Jan 2026

Courtyard by Marriott San Diego Downtown Little Italy
Nice room. Great location
Reviewed on 20 Jan 2026

The Dana on Mission Bay
Easy check-in, free room upgrade, clean room, nice amenities and beautiful hotel grounds.
Reviewed on 20 Jan 2026

The US Grant, a Luxury Collection Hotel, San Diego
Staff was very welcoming. Room was clean and large. Only negative is reservation said city view and our view was an old building across street that was empty, perhaps receiving some rehab. I guess that was the view of the city, but i inferred city view on reservation suggested our room would have ...
Reviewed on 19 Jan 2026


