What's it like in Otay Mesa?

Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa .

How many hotels will I find in the Otay Mesa area?

Expedia has 5 Otay Mesa hotels and other accommodation options, and one might make a good home base for venturing out into the greater San Diego area.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.

What is there to do in this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

Top 10 Otay Mesa Hotels of 2025

Top 10 Hotels in Otay Mesa, San Diego

"Great stay, close to the Cross Border Xpress "

RM670 total

includes taxes & fees

3 Jul - 4 Jul

"Great rooms no hot water when I got there other than that good "

RM517 total

includes taxes & fees

9 Jul - 10 Jul

"Great place"

RM1,209 total

includes taxes & fees

6 Jul - 7 Jul

"Great location"

RM1,003 total

includes taxes & fees

6 Jul - 7 Jul

"Love this hotel "

"Walking distance to the beach, great breakfast option, easy parking."

RM1,456 total

includes taxes & fees

10 Jul - 11 Jul

2 outdoor pools, a heated pool, pool loungers

"Great place to stay!"

RM1,164 total

includes taxes & fees

2 Jul - 3 Jul

3 outdoor pools, pool cabanas (surcharge), pool umbrellas

"I enjoyed the location and the pool area."

"Great place for a family vaca! "

RM1,424 total

includes taxes & fees

30 Jun - 1 Jul

"Amazing location "

RM879 total

includes taxes & fees

6 Jul - 7 Jul

"Great location within walking distance from the places we wanted to visit."

RM473 total

includes taxes & fees

29 Jun - 30 Jun

"Awesome hotel"

"Great spot for business travelers "

RM999 total

includes taxes & fees

30 Jun - 1 Jul

"The staffs are super friendly and the location is perfect in the downtown areas and easy to walk around."

"Excellent hotel!"

RM606 total

includes taxes & fees

6 Jul - 7 Jul

"Nice place "

RM1,046 total

includes taxes & fees

13 Jul - 14 Jul

Desk, blackout curtains, soundproofing, free WiFi

"Affordable and near the border for convenience. "

"Beautiful stay!"

RM870 total

includes taxes & fees

3 Jul - 4 Jul

"Loved our stay"

RM1,829 total

includes taxes & fees

6 Jul - 7 Jul

"Location perfect great staff clean rooms"

RM772 total

includes taxes & fees

30 Jun - 1 Jul

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

2 out of top 10 points of interest in this area

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Seaport Village and Petco Park are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

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Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

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Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

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Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

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