Uptown - Upper Duval

Key West

Key West Butterfly and Nature Conservatory featuring flowers, zoo animals and animals
Key West Butterfly and Nature Conservatory which includes flowers, animals and zoo animals
South Beach which includes a beach and a coastal town as well as a large group of people
South Beach featuring swimming, a luxury hotel or resort and a beach
Key West Butterfly and Nature Conservatory which includes signage

Popular places to visit

Southernmost Point

Southernmost Point

4/5(39 reviews)

Snap a memorable photograph from the edge of North America at this monumental landmark.

Southernmost Point
South Beach

South Beach

4.5/5(8 reviews)

The southernmost beach in the continental United States is a convenient sandy enclave, just minutes from the center of town.

South Beach
Key West Butterfly and Nature Conservatory which includes animals, zoo animals and food

Key West Butterfly and Nature Conservatory

4.5/5(10 reviews)

With about 60 species of butterfly, an indoor waterfall and a tropical rainforest, this nature conservatory is one of the most popular attractions in Key West.

Key West Butterfly and Nature Conservatory

Things to do

Florida: Key West Overseas Highway Self-Driving Tour

Florida: Key West Overseas Highway App-Based Driving Audio Tour

RM72
per traveller
80% of travellers recommend
Florida: Key West Overseas Highway App-Based Driving Audio Tour
Key West’s Old Town Treasures: A Self-Guided Audio Tour

Key West’s Old Town Treasures: A Self-Guided Audio Tour

RM63
per adult
Key West’s Old Town Treasures: A Self-Guided Audio Tour
Bahama Village Walking Tour

Bahama Village Walking Tour

RM127
per adult
Bahama Village Walking Tour
Florida Key West Self-Guided Walking Audio Tour

Florida Key West Self-Guided Walking Audio Tour Via App

RM42
per traveller
Florida Key West Self-Guided Walking Audio Tour Via App
Key West History And Culture Walking Tour

Southernmost Key West History and Culture Small-Group Walking Tour

RM169
per adult
Southernmost Key West History and Culture Small-Group Walking Tour
An Audio Guide of Key West’s Journey From Village to Micro State

An Audio Guide of Key West’s Journey From Village to Micro State

RM51
per adult
An Audio Guide of Key West’s Journey From Village to Micro State
See all activities in Key West

Top hotels in Uptown - Upper Duval

Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

4 out of 5
1319 Duval Street, Key West, FL
Fully refundable
The price is RM619 per night from 30 Sept to 1 Oct
RM619
RM980 total
30 Sept - 1 Oct
includes taxes & fees
Stay at this 4-star beach hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the bar in our reviews. ...
8.6/10 Excellent! (2,729 reviews)
"Overall, it was a great experience. However, the bedroom was extremely small, it didn’t have any kind of storage, not even a small closet or dresser. We had to keep our belongings in our luggage the whole stay."

Reviewed on 9 Sept 2025

Southernmost Beach Resort and Guesthouses
The Reach Key West, Curio Collection by Hilton

The Reach Key West, Curio Collection by Hilton

4 out of 5
1435 Simonton Street, Key West, FL
The price is RM828 per night from 25 Sept to 26 Sept
RM828
RM1,184 total
25 Sept - 26 Sept
includes taxes & fees
Stay at this 4-star beach resort in Key West. Enjoy a full-service spa, a private beach, and breakfast (surcharge). Our guests praise the helpful staff and the ...
8.4/10 Very Good! (1,001 reviews)
"Loved the hotel but loved its sister property Casa Marina even more ! Very opulent ."

Reviewed on 11 Sept 2025

The Reach Key West, Curio Collection by Hilton
The Southernmost Inn - Adults Only

The Southernmost Inn - Adults Only

3 out of 5
525 United Street, Key West, FL
The price is RM416 per night from 24 Sept to 25 Sept
RM416
RM657 total
24 Sept - 25 Sept
includes taxes & fees
Stay at this 3-star hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...
8.2/10 Very Good! (1,170 reviews)
"Love this place! The staff is amazing ( especially Kia!!) Very relaxing and calm."

Reviewed on 10 Sept 2025

The Southernmost Inn - Adults Only
Southwinds Motel

Southwinds Motel

2 out of 5
1321 Simonton Street, Key West, FL
The price is RM526 per night from 17 Sept to 18 Sept
RM526
RM710 total
17 Sept - 18 Sept
includes taxes & fees
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and a 24-hour front desk. Our guests praise the breakfast and the pool in our reviews. ...
8.6/10 Excellent! (1,172 reviews)
"the staff was so helpful the room was clean my husband met so many people at the local bar and he seen people he met the year before we try to stay in the same place ever year we will be coming back next year"

Reviewed on 9 Sept 2025

Southwinds Motel
Santa Maria Suites

Santa Maria Suites

4 out of 5
1401 Simonton St, Key West, FL
The price is RM994 per night from 17 Sept to 18 Sept
RM994
RM1,308 total
17 Sept - 18 Sept
includes taxes & fees
Stay at this 4-star resort in Key West. Enjoy free WiFi, 2 outdoor pools, and a fitness center. Our guests praise the pool and the helpful staff in our reviews. ...
9.6/10 Exceptional! (1,004 reviews)
Beautiful resort! Very tropical!
"Everything was great! Beautiful suite. Only complaints I had was that the keurig machine did not work and there was a crack under the door big enough for a tiny gecko to crawl through and come inside the suite."

Reviewed on 11 Sept 2025

Santa Maria Suites
Kona Kai Oasis

Kona Kai Oasis

3 out of 5
630 South Street, Key West, FL
Stay at this 3-star guesthouse in Key West. Enjoy free WiFi, free parking, and a garden. Our guests praise the helpful staff in our reviews. Popular attractions ...
8/10 Very Good! (555 reviews)
"Not many towels and the fridge was dirty"

Reviewed on 6 Sept 2025

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Kona Kai Oasis
See all 2,796 properties in Uptown - Upper Duval
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Uptown - Upper Duval

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Old Town Key West

5/5(6 area reviews)

While visiting Old Town Key West, you might make a stop by sights like Duval Street and Saint Mary Star of the Sea.

Old Town Key West
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Downtown Key West

While visiting Downtown Key West, you might make a stop by sights like Duval Street and Ernest Hemingway Home and Museum.

Downtown Key West
Harry S. Truman Little White House featuring cycling and a house

Bahama Village

5/5(1 area review)

Bahama Village is noteworthy for its historical sites, and you can make a stop at top attractions like Duval Street and Key West Lighthouse and Keeper's Quarters Museum.

Bahama Village
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Casa Marina

While visiting Casa Marina, you might make a stop by sights like Clarence S. Higgs Memorial Beach Park and Florida Keys Beaches.

Casa Marina
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Key West Historic District

4.5/5(66 area reviews)

Travellers to Key West Historic District praise its fantastic nightlife. If you've got some more time to explore, be sure to stop by Duval Street and Saint Mary Star of the Sea.

Key West Historic District
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White Street Gallery District

If you're looking for some top things to see and do in White Street Gallery District and surrounding area, you can visit Duval Street and Saint Mary Star of the Sea.

White Street Gallery District

Uptown - Upper Duval