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Top hotels in East Prairie

Best Western Plus Sikeston
120 S Interstate Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is RM375 per night from 10 Aug to 11 Aug
RM375
RM427 total
10 Aug - 11 Aug
includes taxes & fees
8.2/10 Very Good! (1,009 reviews)
"We were travelling through and were pleasantly surprised at how well maintained the hotel was. Also breakfast was great with eggs and biscuits and gravy. Would definitely stay again."
Reviewed on 8 Jul 2025

Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is RM434 per night from 3 Aug to 4 Aug
RM434
RM499 total
3 Aug - 4 Aug
includes taxes & fees
9.4/10 Exceptional! (1,006 reviews)
"The staff here from check in to the morning breakfast were welcoming and friendly. Cost was reasonable. I loved seeing the dogs and that it is pet friendly. Everything was clean. The location was close to places to eat - we even walked to El Bracero for dinner. I would highly recommend"
Reviewed on 11 Jul 2025

Pear Tree Inn Sikeston
2602 E Malone Avenue, Sikeston, MO
Fully refundableReserve now, pay when you stay
The price is RM340 per night from 20 Jul to 21 Jul
RM340
RM391 total
20 Jul - 21 Jul
includes taxes & fees
9.2/10 Wonderful! (1,004 reviews)
"Excellent place to stay. Good breakfast choices. Good pool and hot tub."
Reviewed on 9 Jul 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.