𝗧𝗢𝗣 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 East Prairie from RM263 (2026) - Fully Refundable Options

A tree-lined landscape with a river and fields.

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Go beyond your typical stay in East Prairie

Pet friendly

Apartment

Pool

Condo

Family friendly

Waterpark

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Our top choices for East Prairie hotels

Desk, blackout curtains, iron/ironing board, free cots/infant beds

1. Drury Inn & Suites Sikeston, MO

Sikeston

Scott Andrew

RM380

RM437 total

includes taxes & fees

13 Sept - 14 Sept

Hypo-allergenic bedding, down duvets, desk, iron/ironing board

Indoor pool, open 8 AM to 11 PM, pool loungers

2. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

RM433

RM490 total

includes taxes & fees

20 Sept - 21 Sept

3. Hampton Inn Sikeston

Sikeston

Jeffrey

RM411

RM465 total

includes taxes & fees

13 Sept - 14 Sept

Laptop workspace, iron/ironing board, free cots/infant beds

4. Best Western Plus Sikeston I-55

Sikeston

Crystal

RM352

RM402 total

includes taxes & fees

20 Sept - 21 Sept

5. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

RM408

RM462 total

includes taxes & fees

13 Sept - 14 Sept

6. The Riverstone Hotel Charleston-Sikeston

Charleston

Bobby

RM269

RM298 total

includes taxes & fees

7 Sept - 8 Sept

Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

7. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

France

RM241

RM267 total

includes taxes & fees

8 Sept - 9 Sept

1 bedroom, desk, laptop workspace, blackout curtains

8. Days Inn and Suites by Wyndham Sikeston

Sikeston

Lori

RM268

RM306 total

includes taxes & fees

7 Sept - 8 Sept

9. Comfort Inn & Suites Sikeston I-55

Sikeston

Lakeysha

RM359

RM409 total

includes taxes & fees

27 Sept - 28 Sept

Desk, blackout curtains, iron/ironing board (on request), free WiFi

10. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Sharika West

RM277

RM316 total

includes taxes & fees

9 Sept - 10 Sept

Desk, iron/ironing board, free WiFi, alarm clocks

11. Eagle Inn Charleston

Charleston

Jackson

RM311

RM346 total

includes taxes & fees

8 Sept - 9 Sept

Desk, laptop workspace, blackout curtains, free WiFi

12. Super 8 By Wyndham Marston

Marston

Rachel

RM271

RM309 total

includes taxes & fees

1 Oct - 2 Oct

Iron/ironing board, free cots/infant beds, free WiFi, alarm clocks

13. Quality Inn Cairo I-57

Cairo

Susan

RM283

RM314 total

includes taxes & fees

2 Oct - 3 Oct

Iron/ironing board (on request), free WiFi, bed sheets

14. Country Yard Inn and Suite

Sikeston

William

RM240

RM286 total

includes taxes & fees

16 Sept - 17 Sept

15. Sleep Inn at Discovery Park of America

Union City

Ben

RM320

RM380 total

includes taxes & fees

27 Sept - 28 Sept

16. Hampton Inn Union City

Union City

James

RM412

RM490 total

includes taxes & fees

20 Sept - 21 Sept

17. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

Kevin

RM231

RM263 total

includes taxes & fees

14 Sept - 15 Sept

18. Holiday Inn Express & Suites Union City by IHG

Union City

Terri

RM445

RM528 total

includes taxes & fees

20 Sept - 21 Sept

19. Quality Inn Union City US 51

Union City

Chadwick

RM271

RM322 total

includes taxes & fees

25 Sept - 26 Sept

Iron/ironing board, free WiFi, bed sheets

20. Country Hearth Inn & Suites Union City

Union City

Jade

RM241

RM286 total

includes taxes & fees

26 Sept - 27 Sept

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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

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Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie

Top East Prairie Hotel Reviews

Days Inn and Suites by Wyndham Sikeston

8/10 Good

"Bed was very comfortable . No water pressured for shower"

Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent

"The staff were friendly and accommodating and the room was clean and comfortable."

The Riverstone Hotel Charleston-Sikeston

10/10 Excellent

"Staff was excellent. Check in was quick. Rooms were clean."

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"For a older hotel. It was pleasant. Very good staff"

Best Western Plus Sikeston I-55

10/10 Excellent

"We were greeted with a warm smile from a really nice gentleman that checked us in. He chatted with us the entire time we checked in. He gave us ideas where to eat and Lamberts won. The hotel and room was very clean. Breakfast was great. They serve something hot everyday like biscuits and gravy, eggs, sausage and some days bacon. Highly recommend this hotel."

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Very nice and clean property."

Holiday Inn Express & Suites Union City by IHG

10/10 Excellent

"na"

Hampton Inn Sikeston

10/10 Excellent

"Very clean and very nice"

Reelfoot Lake Inn

10/10 Excellent

"clean room, nice lake view, very quiet area. Just a good decent place to stay. Not a fancy 5 star hotel, but well worth it to me. Great place....Thanks!"

More cheap stays in East Prairie