𝗧𝗢𝗣 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 East Prairie from RM261 (2026) - Fully Refundable Options

A tree-lined landscape with a river and fields.

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Go beyond your typical stay in East Prairie

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Our top choices for East Prairie hotels

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

1. Drury Inn & Suites Sikeston, MO

Sikeston

Tim

RM384

RM441 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

2. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Roslyn

RM412

RM469 total

includes taxes & fees

1 Nov - 2 Nov

A building with a fountain and flower beds in front.

A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.

A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.

3. The Riverstone Hotel Charleston-Sikeston

Charleston

Kathleen

RM271

RM304 total

includes taxes & fees

23 Oct - 24 Oct

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

4. Best Western Plus Sikeston I-55

Sikeston

Shelley

RM326

RM371 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.

A reception area with a counter, a flat-screen TV, and a window with blinds.

A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

5. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

William

RM243

RM272 total

includes taxes & fees

22 Oct - 23 Oct

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

6. Hampton Inn Sikeston

Sikeston

Lori

RM430

RM489 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

7. TownePlace Suites by Marriott Sikeston

Sikeston

Rubin

RM445

RM506 total

includes taxes & fees

29 Oct - 30 Oct

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.

A kitchenette with a coffee machine, a kettle, and storage shelves.

8. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

RM396

RM450 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Craig

RM284

RM323 total

includes taxes & fees

21 Oct - 22 Oct

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A spacious lobby with a central atrium, a piano, and a reception desk.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

10. Days Inn and Suites by Wyndham Sikeston

Sikeston

David

RM271

RM309 total

includes taxes & fees

1 Nov - 2 Nov

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

11. Comfort Inn & Suites Sikeston I-55

Sikeston

Fred

RM323

RM369 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.

A bathroom with a bathtub, toilet, and shower curtain.

A reception area with a counter, a coffee machine, and seating.

12. Country Yard Inn and Suite

Sikeston

William

RM239

RM284 total

includes taxes & fees

21 Oct - 22 Oct

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A bathroom with a sink, mirror, towel rack, shower, and toilet.

A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

13. Eagle Inn Charleston

Charleston

Jackson

RM269

RM302 total

includes taxes & fees

21 Oct - 22 Oct

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.

A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.

A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.

14. Super 8 By Wyndham Marston

Marston

Brenda

RM228

RM261 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

A motel with a covered entrance, multiple rooms, and a parking lot.

15. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

Laura

RM233

RM266 total

includes taxes & fees

27 Oct - 28 Oct

A hotel lobby with a reception desk, seating area, and a large window.

A Quality Inn hotel with a green sign, a covered outdoor area, and a parking lot.

A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

16. Quality Inn Cairo I-57

Cairo

Santiago

RM278

RM309 total

includes taxes & fees

13 Nov - 14 Nov

A reception area with a reception desk, two blue armchairs, a round table, and a glass door leading outside.

A large indoor swimming pool with a tiled floor, surrounded by seating areas and tables.

An outdoor patio area with a blue sectional sofa, an orange ottoman, and black metal chairs.

A modern building with a covered entrance, a nameplate, and a landscaped area with shrubs and a street lamp.

17. Sleep Inn at Discovery Park of America

Union City

Ben

RM297

RM353 total

includes taxes & fees

15 Nov - 16 Nov

A modern hotel lobby with a reception desk, seating areas, and a large abstract art piece on the wall.

A modern office space with a long desk, two chairs, and a computer. There are multiple tables and chairs in the background, and a colorful striped artwork on the wall.

An indoor swimming pool with clear water, safety signs, and chairs around the pool.

A modern meeting room with red and grey chairs, a large flat-screen TV, and a wooden cabinet with decorative items.

18. Holiday Inn Express & Suites Union City by IHG

Union City

Kevin

RM482

RM572 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with a fire pit, cushioned chairs, and a metal fence.

An indoor swimming pool with a no diving sign, lounge chairs, and a no diving sign at the bottom.

A modern hotel lobby with multiple seating areas, a kitchen in the background, and large windows with curtains.

A Hampton Inn hotel with a modern design, featuring a well-lit entrance and a clear signage.

19. Hampton Inn Union City

Union City

Melody

RM416

RM494 total

includes taxes & fees

1 Nov - 2 Nov

A hotel dining area with a long counter, multiple tables, and chairs. There are curtains on the windows, a lamp, and a view of the outdoors.

A hotel room with a large bed, a desk, a chair, and a bedside table.

A hotel room with a dining area, a sofa set, a TV mounted on the wall, and a patterned carpet.

A reception area with a wooden counter, a television, and a sign for 'Quality Inn by Marriott'.

20. Quality Inn Union City US 51

Union City

Logan

RM274

RM326 total

includes taxes & fees

10 Nov - 11 Nov

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Hotels recommended for families in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

RM284

RM323 total

includes taxes & fees

21 Oct - 22 Oct

Super 8 by Wyndham Sikeston/Miner Area

Sikeston

RM233

RM266 total

includes taxes & fees

27 Oct - 28 Oct

Days Inn and Suites by Wyndham Sikeston

Sikeston

RM271

RM309 total

includes taxes & fees

1 Nov - 2 Nov

Drury Inn & Suites Sikeston, MO

Sikeston

RM384

RM441 total

includes taxes & fees

25 Oct - 26 Oct

Best Western Plus Sikeston I-55

Sikeston

RM326

RM371 total

includes taxes & fees

8 Nov - 9 Nov

Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

RM396

RM450 total

includes taxes & fees

8 Nov - 9 Nov

Hampton Inn Sikeston

Sikeston

RM430

RM489 total

includes taxes & fees

1 Nov - 2 Nov

Fairfield Inn & Suites by Marriott Sikeston

Sikeston

RM412

RM469 total

includes taxes & fees

1 Nov - 2 Nov

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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

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Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie

Top East Prairie Hotel Reviews

Super 8 By Wyndham Marston

8/10 Good

"Got there late and staff was very helpful. Room was clean and comfortable"

Comfort Inn & Suites Sikeston I-55

10/10 Excellent

"The room was nice"

Hampton Inn Sikeston

10/10 Excellent

"Every part of this stay was excellent, from check in to check out. Helpful and friendly staff, wonderful, clean and well furnished room, delicious breakfast. Highly recommend."

Hampton Inn Union City

10/10 Excellent

"Very clean Comfy beds Good variety of breakfast items"