Hotels in Lake Nona Medical City, Orlando

Start date: Check-in selected.
To Date
End date: Check-out

    Change your mind

    Book hotels with free cancellation

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
19 Oct - 20 Oct
Tomorrow
20 Oct - 21 Oct
Next weekend
24 Oct - 26 Oct
In two weeks
31 Oct - 2 Nov

Filter by

Guest rating
Guest rating
Star rating

Top 10 Hotels in Lake Nona Medical City, Orlando

Lounge
Aloft Orlando Lake Nona
Aloft Orlando Lake Nona
3.0 star property
9.6 out of 10, Exceptional, (232)
"Fun hotel with clean rooms , nice restaurants"
United States
Melissa
The price is RM587
RM661 total
includes taxes & fees
27 Oct - 28 Oct
Aloft Orlando Lake Nona
Outdoor pool
Courtyard Orlando Lake Nona
Courtyard Orlando Lake Nona
3.0 star property
9.6 out of 10, Exceptional, (577)
"Great stay"
United States
Romulo
The price is RM680
RM773 total
includes taxes & fees
30 Oct - 31 Oct
Courtyard Orlando Lake Nona
Outdoor pool
Residence Inn Orlando Lake Nona
Residence Inn Orlando Lake Nona
3.0 star property
9.6 out of 10, Exceptional, (323)
"Good hotel "
China
lily
The price is RM756
RM859 total
includes taxes & fees
2 Nov - 3 Nov
Residence Inn Orlando Lake Nona
Lobby
La Quinta Inn & Suites by Wyndham Orlando UCF
La Quinta Inn & Suites by Wyndham Orlando UCF
3.0 star property
8.6 out of 10, Excellent, (2695)
"Great hotel for one night stay."
United States
Juan
The price is RM402
RM453 total
includes taxes & fees
2 Nov - 3 Nov
La Quinta Inn & Suites by Wyndham Orlando UCF
Terrace/patio
The Delaney Hotel
The Delaney Hotel
3.5 star property
9.6 out of 10, Exceptional, (1026)
"Clean room and staff was super nice. Having the restaurant downstairs was convenient and it’s an excellent location. "
United States
Narmeen
The Delaney Hotel
Premium bedding, in-room safe, desk, blackout curtains
Ramada by Wyndham Suites Orlando Airport
Ramada by Wyndham Suites Orlando Airport
3.0 star property
8.2 out of 10, Very good, (5007)
"Very nice stay"
United States
Donald
The price is RM354
RM398 total
includes taxes & fees
20 Oct - 21 Oct
Ramada by Wyndham Suites Orlando Airport
Pillow-top beds, in-room safe, desk, blackout curtains
Wingate by Wyndham - Orlando International Airport
Wingate by Wyndham - Orlando International Airport
3.0 star property
8.8 out of 10, Excellent, (3679)
"Great hotel"
United States
Jon
The price is RM323
RM364 total
includes taxes & fees
20 Oct - 21 Oct
Wingate by Wyndham - Orlando International Airport
Exterior
Country Inn & Suites by Radisson, Orlando Airport, FL
Country Inn & Suites by Radisson, Orlando Airport, FL
3.0 star property
7.8 out of 10, Good, (4108)
"Beautiful hotel"
United States
Malikah S
The price is RM256
RM288 total
includes taxes & fees
21 Oct - 22 Oct
Country Inn & Suites by Radisson, Orlando Airport, FL
Outdoor pool, pool loungers
Wyndham Garden Orlando Airport
Wyndham Garden Orlando Airport
3.0 star property
9.0 out of 10, Wonderful, (3890)
"Wonderful Hotel, would stay here about! "
United States
Gregory
The price is RM402
RM453 total
includes taxes & fees
4 Nov - 5 Nov
Wyndham Garden Orlando Airport
Dining
La Quinta Inn & Suites by Wyndham Orlando Airport North
La Quinta Inn & Suites by Wyndham Orlando Airport North
3.0 star property
7.4 out of 10, Good, (496)
"Good value for money, good breakfast, friendly staff"
United Kingdom
Harvey
The price is RM287
RM323 total
includes taxes & fees
27 Oct - 28 Oct
La Quinta Inn & Suites by Wyndham Orlando Airport North
Water park
Ramada by Wyndham Hotel & Water Park
Ramada by Wyndham Hotel & Water Park
3.0 star property
7.2 out of 10, Good, (1506)
"Excellent staff and service "
United States
MARITZA
The price is RM135
RM273 total
includes taxes & fees
27 Oct - 28 Oct
Ramada by Wyndham Hotel & Water Park
Front of property – evening/night
SPOT X Hotel Orlando/Intl Dr by The Red Collection
SPOT X Hotel Orlando/Intl Dr by The Red Collection
3.0 star property
8.6 out of 10, Excellent, (2824)
"Exelente hotel nos encanto "
United States
Carmen
The price is RM253
RM361 total
includes taxes & fees
10 Nov - 11 Nov
SPOT X Hotel Orlando/Intl Dr by The Red Collection
Front of property
The Eo Inn - Downtown
The Eo Inn - Downtown
3.0 star property
8.0 out of 10, Very good, (1008)
"I loved this hotel. The staff was very down to earth "
United States
Eddie
The price is RM643
RM723 total
includes taxes & fees
17 Nov - 18 Nov
The Eo Inn - Downtown
Outdoor pool, open 9 AM to 10 PM, pool loungers
Orlando Palms Hotel
Orlando Palms Hotel
2.5 star property
7.6 out of 10, Good, (2157)
"Great place highly recommend "
United States
Edwin
Orlando Palms Hotel
Outdoor pool, open 8:00 AM to 10:00 PM, pool loungers
Lake Nona Wave Hotel
Lake Nona Wave Hotel
4.0 star property
9.6 out of 10, Exceptional, (1021)
"This is the nicest hotels we’ve ever stayed at in Orlando. It is outstanding in every way!"
Canada
Dennis
The price is RM1,169
RM1,327 total
includes taxes & fees
1 Nov - 2 Nov
Lake Nona Wave Hotel
Outdoor pool
DoubleTree by Hilton at the Entrance to Universal Orlando
DoubleTree by Hilton at the Entrance to Universal Orlando
4.0 star property
8.4 out of 10, Very good, (6790)
"Great stay"
United States
Bianca
The price is RM412
RM464 total
includes taxes & fees
27 Oct - 28 Oct
DoubleTree by Hilton at the Entrance to Universal Orlando
1 bedroom, premium bedding, minibar, in-room safe
Kompose Boutique Resort at Theme Parks
Kompose Boutique Resort at Theme Parks
3.0 star property
9.4 out of 10, Exceptional, (1572)
"Great place to stay"
United States
Maribel
The price is RM248
RM281 total
includes taxes & fees
18 Nov - 19 Nov
Kompose Boutique Resort at Theme Parks
View from property
Avanti International Resort
Avanti International Resort
4.0 star property
7.8 out of 10, Good, (4163)
"Great pool area especially for children. Excellent location to explore International Drive, as its really close to restaurants, icon park etc. "
United Kingdom
fiona
Avanti International Resort
Outdoor pool, pool cabanas (surcharge), pool umbrellas
Hyatt Regency Orlando
Hyatt Regency Orlando
4.5 star property
9.2 out of 10, Wonderful, (1789)
"Great beautiful hotel "
United States
Barbara
The price is RM567
RM873 total
includes taxes & fees
15 Nov - 16 Nov
Hyatt Regency Orlando
Terrace/patio
Hyatt Regency Orlando International Airport
Hyatt Regency Orlando International Airport
4.0 star property
9.4 out of 10, Exceptional, (3689)
"Great place to stay, clean and safe. "
United States
Melanie
The price is RM832
RM937 total
includes taxes & fees
20 Oct - 21 Oct
Hyatt Regency Orlando International Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas for the activities you enjoy most.

International Drive District

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

Magic Kingdom® Theme Park featuring rides and interior views as well as a couple
Photo by ©Disney
Open Photo by ©Disney

Bay Lake

Exciting theme parks plentiful wildlife and top sights from Epcot® to Walt Disney World® Resort – discover Bay Lake, a destination also famous for its entertainment.

Universal Studios Florida® featuring night scenes, a city and signage

Florida Center

If you're spending some time in Florida Center, Universal Orlando Resort and Universal Studios Florida are top sights worth seeing.

Downtown Orlando

One of the most popular neighborhoods in Florida, this bustling area is full of art galleries, shops, bars and restaurants.

Champions Gate

Ample dining options and top golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.

Top Lake Nona Medical City Hotel Reviews

Sheraton Vistana Villages Resort Villas, I-Drive/Orlando

Sheraton Vistana Villages Resort Villas, I-Drive/Orlando

10/10 Excellent
"Clean and comfortable "
Leslie 1-night trip
Posted 8 hours ago
Sheraton Vistana Villages Resort Villas, I-Drive/Orlando

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Lake Nona Medical City?
Lake Nona Medical City is a neighbourhood that travellers like for its restaurants.
What's the best accommodation in Lake Nona Medical City?
Based on Expedia customer reviews, Aloft Orlando Lake Nona is the highest ranked property in Lake Nona Medical City. This hotel offers a restaurant and an outdoor pool. Other favourite options in the area include Residence Inn Orlando Lake Nona and Courtyard Orlando Lake Nona.
How many hotels will I find in Lake Nona Medical City?
Expedia has 5 Lake Nona Medical City hotels and other accommodation options, and one might make a good home base for venturing out into the greater Orlando area.
If I need to cancel my hotel reservation in Lake Nona Medical City, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Lake Nona Medical City.
What is there to do around this Orlando neighbourhood?
Places you might want to visit in the area around Lake Nona Medical City include Eagle Creek Golf Club and Austin-Tindall Regional Park. When you're sightseeing around the area, Lake Hart and Kissimmee Bay Country Club are a couple of other sights to visit.