Hotels near 21c Museum Hotel

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28 Dec - 29 Dec
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29 Dec - 30 Dec
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2 Jan - 4 Jan
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9 Jan - 11 Jan

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Our top choices for 21c Museum Hotel hotels

Street view
Louisville Bourbon Inn

Louisville Bourbon Inn

Louisville Bourbon Inn
5.0 star property
Old Louisville, 2.8 km from 21c Museum Hotel
10.0 out of 10, Exceptional, (20)
"Great breakfast. Frittata, French toast, eggs, bacon, sausage, grapes, toast, biscuits and gravy - all were excellent. "
United States
Gaven
The price is RM1,073
RM1,246 total
includes taxes & fees
29 Dec - 30 Dec
Louisville Bourbon Inn
Exterior
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
4.0 star property
Downtown Louisville, 0.9 km from 21c Museum Hotel
9.6 out of 10, Exceptional, (428)
"Great location. Great restraunt, great staff. Pleasurable experience!"
United States
Harrison
The price is RM709
RM835 total
includes taxes & fees
11 Jan - 12 Jan 2026
Hotel Distil, Autograph Collection
Free daily full breakfast
Market Street Inn

Market Street Inn

Market Street Inn
3.5 star property
2.1 km from 21c Museum Hotel
9.8 out of 10, Exceptional, (120)
"I enjoyed my stay, however the breakfast portion was very small even for a petite person like myself, I was still very hungry after breakfast. There was a cleaning issue with the bathroom that was overlooked by the cleaning staff that I alerted the owners to that will hopefully be fixed for future visitors. The house is great and very clean overall. The owners are very nice."
United States
Megan
The price is RM750
RM848 total
includes taxes & fees
29 Dec - 30 Dec
Market Street Inn
View from room
The Grady

The Grady

The Grady
4.0 star property
Downtown Louisville, 0.1 km from 21c Museum Hotel
9.4 out of 10, Exceptional, (1010)
"Such an amazing hotel...restaurant is delicious! "
United States
Craig
The price is RM587
RM691 total
includes taxes & fees
3 Jan - 4 Jan 2026
The Grady
Front of property
DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast

DuPont Mansion Bed & Breakfast
3.0 star property
Old Louisville, 2.8 km from 21c Museum Hotel
9.8 out of 10, Exceptional, (97)
"Breakfast was wonderful, great place to stay!"
United States
Janie
The price is RM579
RM671 total
includes taxes & fees
30 Dec - 31 Dec
DuPont Mansion Bed & Breakfast
Dining
Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row

Cambria Hotel Louisville Downtown-Whiskey Row
3.0 star property
Downtown Louisville, 1.2 km from 21c Museum Hotel
9.4 out of 10, Exceptional, (1001)
"The staff and lobby were top tier!"
United States
Emily
The price is RM386
RM454 total
includes taxes & fees
18 Jan - 19 Jan 2026
Cambria Hotel Louisville Downtown-Whiskey Row
Premium bedding, down duvets, memory-foam beds, individually furnished
Stellar Suites

Stellar Suites

Stellar Suites
4.5 star property
East Market District, 2.2 km from 21c Museum Hotel
9.6 out of 10, Exceptional, (117)
"Clean and great location "
United States
Greg
The price is RM478
RM766 total
includes taxes & fees
11 Jan - 12 Jan 2026
Stellar Suites
Lobby
The Brown Hotel

The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville, 1.2 km from 21c Museum Hotel
9.4 out of 10, Exceptional, (1164)
"Fantastic place to stay in Louisville."
United States
Nathaniel
The Brown Hotel
Exterior
Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY

Homewood Suites by Hilton Louisville Downtown, KY
3.0 star property
Downtown Louisville, 0.1 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (1003)
"Great location"
United States
Pedro
The price is RM415
RM488 total
includes taxes & fees
14 Jan - 15 Jan 2026
Homewood Suites by Hilton Louisville Downtown, KY
Front of property
21c Museum Hotel Louisville

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville, < 0.1 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (1002)
"Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!"
United States
Tammy
The price is RM563
RM683 total
includes taxes & fees
1 Jan - 2 Jan 2026
21c Museum Hotel Louisville
Lobby
Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown

Towneplace Suites By Marriott Louisville Downtown
3.0 star property
Downtown Louisville, 0.3 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (517)
"Accommodations were perfect. Staff excellent. Food was very good."
United States
Bennett
The price is RM393
RM462 total
includes taxes & fees
15 Jan - 16 Jan 2026
Towneplace Suites By Marriott Louisville Downtown
Sauna, body treatments, aromatherapy, hot stone massages
Omni Louisville Hotel

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville, 0.8 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (1745)
"This is a beautiful hotel in a great location. Very kind staff and helpful with directions."
United States
Bonnie
The price is RM677
RM797 total
includes taxes & fees
1 Jan - 2 Jan 2026
Omni Louisville Hotel
2 restaurants, breakfast served
Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu

Tempo By Hilton Louisville Downtown Nulu
3.5 star property
Phoenix Hill, 2 km from 21c Museum Hotel
9.4 out of 10, Exceptional, (838)
"Clean, quiet and great location "
United States
Kristine
The price is RM415
RM489 total
includes taxes & fees
12 Jan - 13 Jan 2026
Tempo By Hilton Louisville Downtown Nulu
Bar (on property)
Moxy Louisville Downtown

Moxy Louisville Downtown

Moxy Louisville Downtown
3.5 star property
Downtown Louisville, 0.9 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (702)
"Awesome location and the staff was super friendly"
United States
Kelly
The price is RM421
RM496 total
includes taxes & fees
3 Jan - 4 Jan 2026
Moxy Louisville Downtown
Exterior
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
4.0 star property
Downtown Louisville, 0.8 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (58)
"Amazing property! Best hotel in Louisville! Will be staying there again!"
United States
Norman
The price is RM682
RM802 total
includes taxes & fees
5 Jan - 6 Jan 2026
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
4 restaurants, breakfast, lunch, dinner served; American cuisine
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville, 0.5 km from 21c Museum Hotel
9.0 out of 10, Wonderful, (3909)
"Great place to stay! "
United States
Rochelle
The price is RM540
RM635 total
includes taxes & fees
5 Jan - 6 Jan 2026
Galt House Hotel Trademark Collection by Wyndham
Exterior detail
Central Park Bed & Breakfast

Central Park Bed & Breakfast

Central Park Bed & Breakfast
4.0 star property
Old Louisville, 2.9 km from 21c Museum Hotel
9.4 out of 10, Exceptional, (58)
"Our stay here was excellent in every way! The owners were very sweet and went out of their way to assist us in every way, the rooms were very cozy, and the breakfasts were fantastic. This is the best B&B we've ever stayed."
United States
John
The price is RM549
RM637 total
includes taxes & fees
31 Dec - 1 Jan 2026
Central Park Bed & Breakfast
Property amenity
AC Hotel Louisville Downtown

AC Hotel Louisville Downtown

AC Hotel Louisville Downtown
3.5 star property
East Market District, 2 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (610)
"Everything was amazing, staff was wonderful "
United States
Ashley
The price is RM446
RM525 total
includes taxes & fees
9 Jan - 10 Jan 2026
AC Hotel Louisville Downtown
Hypo-allergenic bedding, in-room safe, desk, laptop workspace
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
4.0 star property
East Market District, 2 km from 21c Museum Hotel
9.2 out of 10, Wonderful, (1021)
"Great location and accommodations."
United States
Steve
The price is RM514
RM605 total
includes taxes & fees
3 Jan - 4 Jan 2026
Hotel Genevieve part of JdV by Hyatt
Dinner served
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
4.0 star property
Downtown Louisville, 0.8 km from 21c Museum Hotel
9.0 out of 10, Wonderful, (1128)
"Staff was courteous, hotel was beautiful and clean, and breakfast was amazing!"
United States
Shunskis
The price is RM495
RM582 total
includes taxes & fees
11 Jan - 12 Jan 2026
Embassy Suites Louisville Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top 21c Museum Hotel Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent
"No breakfast, rooms was very clean"
Terry 1-night trip
Posted 2 days ago
Galt House Hotel Trademark Collection by Wyndham

Hotels near other 21c Museum Hotel attractions

Louisville Science Center

Louisville Science Center

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.
See properties
Kentucky Center for the Performing Arts

Kentucky Center for the Performing Arts

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.
See properties

Frequently asked questions

What's the area like around 21c Museum Hotel?
21c Museum Hotel is located in a family-friendly area of Louisville known for its stunning river views and great live music scene. If you're looking for a convenient place to stay, take a look at the 295 hotels and other accommodation options you'll find within a mile.
What's the best hotel to stay near 21c Museum Hotel?
Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Omni Louisville Hotel and Holiday Inn Express & Suites Louisville Downtown by IHG.
How many hotels are there near 21c Museum Hotel?
Expedia has 295 hotels and other accommodation options within a mile from 21c Museum Hotel.
If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?
Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best deals available near 21c Museum Hotel.
What can I see and do near 21c Museum Hotel?
You might want to spend some time browsing the exhibits at Louisville Science Center, Muhammad Ali Center or Louisville Slugger Museum. Explore landmarks like Belle of Louisville, Whiskey Row and Big Four Bridge. You can watch performances at Kentucky Center for the Performing Arts, Louisville Palace and Derby Dinner Playhouse if you're interested in local theatre.