Top 10 Hotels Near 21c Museum Hotel in Louisville for 2026

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Our top choices for 21c Museum Hotel hotels

A grand staircase with a wooden handrail and carpeted steps, leading to an upper floor.

A spacious dining area with a chandelier, a fireplace, and a view of greenery outside.

A living room with a sofa, armchair, coffee table, fireplace, and large windows.

A covered outdoor seating area with wicker furniture and a wooden railing.

1. Louisville Bourbon Inn

Old Louisville, 2.8 km from 21c Museum Hotel

Roy

RM1,140

RM1,323 total

includes taxes & fees

27 Oct - 28 Oct

A wooden staircase with a balustrade leading to a landing.

A bedroom with a bed, a dresser, a television, and a desk with a lamp.

A two-story brick building with a white porch and a sign reading "Hotel".

A brick building with a covered porch, columns, and potted plants.

2. Market Street Inn

2.1 km from 21c Museum Hotel

"Such a lovely stay at the Market Street Inn. A very charming, comfortable and feels like home kind of place. Carol and Steve are just the kindest owners. They were responsive and accommodating and always available if needed. We also loved meeting Lisa, who made breakfast each morning and took care of any housekeeping needs. We felt like we were treated as family and not just guests. The area and location is perfect, SUCH a cute little town. Plenty of restaurants, shops and entertainment within...

Ryan

RM903

RM1,021 total

includes taxes & fees

27 Oct - 28 Oct

A multi-story hotel with a classic facade, large windows, and a modern glass building adjacent to it.

An indoor dining area with tables set for guests, surrounded by potted plants and hanging lights.

A bar with shelves of liquor bottles and a bartender preparing drinks.

A modern living room with a leather sectional sofa, a glass coffee table, and a view of the city skyline through large windows.

3. Hotel Distil, Autograph Collection

Downtown Louisville, 0.8 km from 21c Museum Hotel

Heather

RM823

RM969 total

includes taxes & fees

22 Nov - 23 Nov

A historic building with a grand entrance, steps leading up to the door, and a sign indicating it is a bed and breakfast.

An outdoor patio with red furniture, including a table and chairs, and two red umbrellas providing shade.

A room with a large mirror, a wooden dresser, a red patterned rug, and a door with a wreath.

A living room with a sofa, a fireplace, a staircase, and a chandelier.

4. DuPont Mansion Bed & Breakfast

Old Louisville, 2.8 km from 21c Museum Hotel

Casey

RM744

RM864 total

includes taxes & fees

1 Nov - 2 Nov

A grand lobby with ornate columns, plush seating, and a chandelier.

A grand lobby with ornate ceiling, large windows, and classic furniture.

A grand lobby with ornate ceiling, multiple seating areas, and a staircase.

A grand lobby with ornate ceiling and chandeliers, a large vase, and a seating area with multiple sofas and armchairs.

5. The Brown Hotel

Downtown Louisville, 1.2 km from 21c Museum Hotel

katisha

RM552

RM650 total

includes taxes & fees

23 Nov - 24 Nov

A spacious indoor patio with a fire pit, wooden pergola, and comfortable seating areas.

A spacious lobby with a large seating area, a chandelier, and a patterned rug.

A spacious hotel lobby with a central seating area, stone accent walls, and a chandelier.

A modern hotel with multiple floors, large windows, and a prominent sign for Homewood Suites.

6. Homewood Suites by Hilton Louisville Downtown, KY

Downtown Louisville, 0.1 km from 21c Museum Hotel

peter

RM466

RM548 total

includes taxes & fees

24 Nov - 25 Nov

A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

A rooftop bar with outdoor seating, including sofas and chairs, and a bar area with a television screen.

A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

A modern interior with a fireplace, bookshelves, and seating areas.

7. Omni Louisville Hotel

Downtown Louisville, 0.8 km from 21c Museum Hotel

Kristan

RM830

RM977 total

includes taxes & fees

16 Nov - 17 Nov

A classical gold statue in front of a multi-story building with large windows and a brick facade.

A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.

A restaurant with multiple dining tables, a long bench seating area, and framed artwork on the walls.

8. 21c Museum Hotel Louisville

Downtown Louisville, < 0.1 km from 21c Museum Hotel

Matt

RM622

RM752 total

includes taxes & fees

22 Nov - 23 Nov

A hotel with a prominent sign, a central courtyard with a sculpture, and a dome structure in the background.

A modern hotel room with a large bed, a city view, and a unique headboard design.

A modern living room with a sofa, a coffee table, a side table with a plant, and a view of a building with a clock tower.

An outdoor seating area with sofas and tables, a fire feature, and a clock tower in the background.

9. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Downtown Louisville, 0.8 km from 21c Museum Hotel

Adrienne Tremonti

RM533

RM627 total

includes taxes & fees

23 Nov - 24 Nov

A modern interior with a fireplace, bookshelves, a green sofa, and leather chairs.

A modern restaurant interior with a staircase, round tables, and a brick wall.

A building with a sign reading "THE GRADY" at the entrance.

A modern hotel room with a large bed, a desk with a flat-screen TV, a green armchair, and a view of the city through large windows.

10. The Grady

Downtown Louisville, 0.1 km from 21c Museum Hotel

Donna

RM636

RM749 total

includes taxes & fees

15 Nov - 16 Nov

An outdoor terrace with tables and chairs, large windows, and a view of the city skyline at sunset.

A modern hotel room with a large bed, a desk with a chair, a flat-screen TV, and a large window offering a city view.

A modern hotel lobby with a reception desk, seating area, and a large abstract ceiling artwork.

A modern hotel lobby with a brick wall, grey sofas, a coffee table, and a large TV screen displaying "TEMPO by Hilton".

11. Tempo By Hilton Louisville Downtown Nulu

Phoenix Hill, 2 km from 21c Museum Hotel

Addison

RM415

RM489 total

includes taxes & fees

25 Nov - 26 Nov

A modern, well-lit room with a large bed, a green sofa, a small round table, and a kitchen area in the background.

A modern bedroom with a bed, a blue sofa, a large rug, and a TV on the wall.

A modern interior with a green wall, black chairs, and a ceiling with exposed beams and lights.

12. Stellar Suites

East Market District, 2.2 km from 21c Museum Hotel

Kevin

RM472

RM762 total

includes taxes & fees

27 Oct - 28 Oct

A spacious indoor area with a large dining table, multiple chairs, a fireplace, and a kitchen area with a bar.

A modern living room with a sectional sofa, a small table, and a floor lamp. Large windows offer a view of a cityscape and a building with glass windows.

A modern lobby with a fireplace, seating area, and a reception desk.

A modern bar area with a circular bar, multiple seating options, and a large screen.

13. Cambria Hotel Louisville Downtown-Whiskey Row

Downtown Louisville, 1.2 km from 21c Museum Hotel

Sarah

RM389

RM458 total

includes taxes & fees

22 Nov - 23 Nov

A cozy living room with a fireplace, a black leather sofa, and a patterned rug.

A modern hotel room with a large bed, a desk with a chair, a TV mounted on the wall, and a window with a city view.

A bar area with a neon 'CHECK IN' sign, a variety of liquor bottles, and a modern seating arrangement.

A modern living room with a sofa, ottomans, a coffee table, and a rug.

14. Moxy Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Alicia

RM483

RM568 total

includes taxes & fees

15 Nov - 16 Nov

A brick building with outdoor seating and a fire pit.

A modern hotel room with a sofa, a small desk, a microwave, and a TV.

A modern restaurant with wooden furniture, a central island, and a high ceiling.

An indoor swimming pool with clear water, surrounded by blue chairs and tables, and a tiled floor.

15. TownePlace Suites by Marriott Louisville North

2.2 km from 21c Museum Hotel

Lori M

RM494

RM559 total

includes taxes & fees

23 Nov - 24 Nov

An outdoor dining area with a long table and wicker chairs, overhead lighting, and a view of the city.

A spacious lounge area with arched windows, comfortable seating, and a variety of plants.

A restaurant with a long counter, multiple tables, and chairs. There are large windows with a view of the city.

16. Hotel Genevieve part of JdV by Hyatt

East Market District, 2 km from 21c Museum Hotel

Tyler

RM552

RM649 total

includes taxes & fees

15 Nov - 16 Nov

A modern hotel with a prominent 'Aloft Hotels' sign, multiple floors, and a corner location with a view of the city skyline.

A modern coffee shop interior with a central island, wooden counter, and large windows.

A modern lounge area with a pool table, comfortable seating, a fireplace, and a brick accent wall.

A modern bar area with sofas, tables, and a bar stocked with bottles.

17. Aloft by Marriott Louisville Downtown

Downtown Louisville, 0.9 km from 21c Museum Hotel

Anthony

RM500

RM588 total

includes taxes & fees

23 Nov - 24 Nov

A covered patio with a stone wall, a glass table, and a bench.

A garden pathway with a lantern, potted plants, and a white fence.

A grand room with a fireplace, a staircase, and a chandelier.

18. Central Park Bed & Breakfast

Old Louisville, 2.9 km from 21c Museum Hotel

Nicole

RM698

RM810 total

includes taxes & fees

28 Oct - 29 Oct

A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

A modern bar area with a marble countertop, seating, and a central bar stocked with bottles.

A modern hotel building with a prominent AC Hotel NULU sign, multiple floors, and a well-lit entrance.

A modern restaurant with high ceilings, large windows, and a mix of round and rectangular tables.

19. AC Hotel Louisville Downtown

East Market District, 2 km from 21c Museum Hotel

Jen

RM585

RM688 total

includes taxes & fees

6 Nov - 7 Nov

A wooden wardrobe with a control panel, a blue towel, and a white towel.

A spacious room with a large dining table, comfortable seating, a sofa, and a view of a bridge.

A modern bar with a long counter, multiple shelves of liquor bottles, and cushioned bar stools.

A balcony with a view of a river, a bridge, and a cityscape.

20. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville, 0.5 km from 21c Museum Hotel

Shun

RM556

RM654 total

includes taxes & fees

8 Nov - 9 Nov

View all properties

Compare popular hotels close to 21c Museum Hotel

Property	Property class	Guest rating
Louisville Bourbon Inn	10.0 Exceptional 25 reviews	View
Market Street Inn	9.8 Exceptional 127 reviews	View
Hotel Distil, Autograph Collection	9.6 Exceptional 512 reviews	View
DuPont Mansion Bed & Breakfast	9.6 Exceptional 150 reviews	View
The Brown Hotel	9.4 Exceptional 1,431 reviews	View

Top 21c Museum Hotel Hotel Reviews

The Brown Hotel

10/10 Excellent

"The hotel was so beautiful and all of the staff were so kind and really went above for the guests!"

Moxy Louisville Downtown

10/10 Excellent

"Hotel was super clean and staff were friendly in a great location"

21c Museum Hotel Louisville

10/10 Excellent

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Towneplace Suites By Marriott Louisville Downtown

10/10 Excellent

"The staff was wonderful. Unfortunately, I had to change rooms because of my error. But the staff was so accommodating. They didn’t make me feel like I was making it an inconvenience. The breakfast was wonderful. I Always greeted with the smile. Very good for being a downtown location."

Aloft by Marriott Louisville Downtown

10/10 Excellent

"Aloft hotels is my go to whenever I travel. Their standard is phenomenal."

Holiday Inn Express & Suites Louisville Downtown by IHG

8/10 Good

"Staff were very nice . No complaints"

Fairfield Inn & Suites by Marriott Louisville Downtown

10/10 Excellent

"We stayed here while attending a comedy show at the Yum Center. Great walking destinations to the Yum Center, 4th Street Live and additional restaurants, and reasonably priced."

The Grady

10/10 Excellent

"Great experience staying at the Grady. Clean. Charm. Convenience."

The Reserve on Main

8/10 Good

"Overall a very good experience! Great location and nice facilities! Fair pricing! Building, Elevator and Room Access was a bit confusing to keep track of multiple codes. TV not connecting to Wifi. Lounge and Kitchen very nicely furnished and fun!"

Other attractions near 21c Museum Hotel

A historic building with ornate architecture, including columns and decorative moldings.

Louisville Science Center

7.8/10 (6 reviews)

Science is all around us, inescapable. Understand important elements of our world with a visit to this science center for all ages.

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Kentucky Center for the Performing Arts

8.8/10 (49 reviews)

Enjoy a pleasant night at the opera or attend a concert, live dance or stage production at this glass-fronted venue in downtown Louisville.

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A modern building with a cylindrical structure and a glass facade.

Muhammad Ali Center

8.8/10 (295 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

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A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

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Golden Statue of David

Find out about the history of Louisville when you spend time at Golden Statue of David. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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Kentucky Museum of Art and Craft

You can spend an afternoon exploring the galleries in Kentucky Museum of Art and Craft during your trip to Louisville. Stroll along the area's riverfront or experience its lively festivals.

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Evan Williams Bourbon Experience

8.6/10 (20 reviews)

You can take time to visit Evan Williams Bourbon Experience during your travels to Louisville. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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SAR Genealogical Research Library: NSSAR Library

You can spend time exploring the galleries in SAR Genealogical Research Library: NSSAR Library in Louisville. Amble around this family-friendly area's riverfront and enjoy its top-notch restaurants.

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Frequently asked questions

What's the area like around 21c Museum Hotel?

21c Museum Hotel is located in a family-friendly area of Louisville known for its stunning river views and great live music scene. If you're looking for a convenient place to stay, take a look at the 292 hotels and other accommodation options you'll find within a mile.

What's the best hotel to stay near 21c Museum Hotel?

Adjacent to 21c Museum Hotel, Galt House Hotel Trademark Collection by Wyndham is one of the top choices for your stay based on our traveller data, and this hotel offers a full-service spa and 4 restaurants. Other good choices within a short distance include Holiday Inn Express & Suites Louisville Downtown by IHG and Omni Louisville Hotel.

How many hotels are there near 21c Museum Hotel?

Expedia has 292 hotels and other accommodation options within a mile from 21c Museum Hotel.

If I need to cancel the hotel reservation for my stay near 21c Museum Hotel, will I receive a refund?

Yes, you'll find most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best deals available near 21c Museum Hotel.

What can I see and do near 21c Museum Hotel?

You might want to spend some time browsing the exhibits at Muhammad Ali Center, Louisville Slugger Museum or Frazier International History Museum. Explore landmarks like Belle of Louisville, Whiskey Row and Big Four Bridge. You can watch performances at Louisville Palace, Derby Dinner Playhouse and Headliners Music Hall if you're interested in local theatre.

Hotels near 21c Museum Hotel

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for 21c Museum Hotel hotels

1. Louisville Bourbon Inn

2. Market Street Inn

3. Hotel Distil, Autograph Collection

4. DuPont Mansion Bed & Breakfast

5. The Brown Hotel

6. Homewood Suites by Hilton Louisville Downtown, KY

7. Omni Louisville Hotel

8. 21c Museum Hotel Louisville

9. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

10. The Grady

11. Tempo By Hilton Louisville Downtown Nulu

12. Stellar Suites

13. Cambria Hotel Louisville Downtown-Whiskey Row

14. Moxy Louisville Downtown

15. TownePlace Suites by Marriott Louisville North

16. Hotel Genevieve part of JdV by Hyatt

17. Aloft by Marriott Louisville Downtown

18. Central Park Bed & Breakfast

19. AC Hotel Louisville Downtown

20. Galt House Hotel Trademark Collection by Wyndham

Compare popular hotels close to 21c Museum Hotel

Top 21c Museum Hotel Hotel Reviews

The Brown Hotel

Moxy Louisville Downtown

21c Museum Hotel Louisville

Towneplace Suites By Marriott Louisville Downtown

Aloft by Marriott Louisville Downtown

Holiday Inn Express & Suites Louisville Downtown by IHG

Fairfield Inn & Suites by Marriott Louisville Downtown

The Grady

The Reserve on Main

Other attractions near 21c Museum Hotel

Louisville Science Center

Kentucky Center for the Performing Arts

Muhammad Ali Center

Louisville Slugger Museum

Golden Statue of David

Kentucky Museum of Art and Craft

Evan Williams Bourbon Experience

SAR Genealogical Research Library: NSSAR Library

Frequently asked questions