Romantic Holidays in Southwest Houston 2026

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Hotel Granduca Houston

1080 Uptown Park Blvd Houston TX

9 min drive from MD Anderson Cancer Center

Stay at this luxury hotel in Houston. Enjoy free Wi-Fi, 2 bars/lounges and breakfast (surcharge). Our guests praise the helpful staff in their reviews. Popular ...

The Greenleigh, River Oaks, Autograph Collection

2525 West Loop S Houston TX

6 min drive from MD Anderson Cancer Center

Stay at this hotel in Houston. Enjoy free Wi-Fi, room service and valet parking (surcharge). Our guests praise the clean rooms in their reviews. Popular attractions ...

4.8/10 (62 reviews)

"The shower didn’t work, no hot water, I paid a deposit November 8 & here it is December 7th still no refund. The transaction shows pending. They all act like they don’t know what’s what ! They use to be upscale now they are 1/10 highly do NOT recommend"

Reviewed on 7 Dec 2024

Omni Houston Hotel

4 Riverway Houston TX

9 min drive from MD Anderson Cancer Center

Stay at this spa hotel in Houston. Enjoy 2 outdoor pools, a full-service spa and 3 bars/lounges. Our guests praise the helpful staff in their reviews. Popular ...

9.2/10 Wonderful! (1,007 reviews)

Couples like: full-service spa, couples spa treatments, bar, hot tub

Travellers say...

"Details matter especially at a 4 star hotel. There should have been a warning that the hotel was under construction and work would begin at 9 am on a Sunday. There was nothing done about my inconvenience. Very unfortunate. I want my money back actually but I’m sure that would be too much."

Reviewed on 28 Sept 2026

See all 1,293 properties in Southwest Houston

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.