Photo by Krystalene Clough

Popular airlines from Chicago O'Hare Intl. Airport (ORD) to McGhee Tyson Airport (TYS)
- American Airlines
American Airlines
- Delta
Delta
- United
United
- Frontier Airlines
Frontier Airlines
- Southwest Airlines
Southwest Airlines
- Plan, book, fly with confidence
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Cheap Flights from Chicago to Knoxville (ORD-TYS)
Prices were available within the past 7 days and start at RM584 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Find the cheapest month to fly from Chicago (ORD) to Knoxville (TYS)
January is typically the cheapest month to fly
From RM 630 - RM 1,518 per traveller.
Graph displaying average flight prices per month
Origin airport | O'Hare Intl. |
Destination airport | McGhee Tyson |
Distance | 760 km |
Average flight time | 2 hours 47 mins |
Perfect flights from Chicago to Knoxville
Your Journey from Chicago to Knoxville
Start your unforgettable journey with Expedia. Our broad selection of flights from Chicago to Knoxville caters to every travel need. Whether you're yearning for a romantic escape, a solo adventure, or a cultural immersion, we've got you covered.
Choosing Your Ideal Flight
With Expedia, you have access to a wide range of airlines, including Delta, American Airlines, United. Our selection of flights from O'Hare Intl. to McGhee Tyson caters to every traveler's requirements, ensuring your journey aligns with your schedule. With options from 20 airlines, you're bound to find the perfect flight.
Maximizing Value with Chicago to Knoxville Flights
Experience the joy of finding cheap flights from O'Hare Intl. to McGhee Tyson that fit your budget. Keep an eye out for our special deals and discounts, and check our flexible one-way fares from RM584 and roundtrip prices *.
Pre-Flight Essentials
Ensure a smooth journey from Chicago to Knoxville with Expedia. From information about check-in times and in-flight amenities to guidance on baggage policies, we provide all the essentials to prepare you for your flight.
Experience the Vibrant Knoxville
Picture yourself stepping off the plane in Knoxville and immersing yourself in the unique atmosphere of Alcoa. From local markets to cultural festivals, each city offers its distinct charm. Make the most of your trip by exploring local attractions and indulging in the local cuisine. With Expedia, explore all this and more, tailored to your budget.
Added Convenience on Your Chicago to Knoxville Flight
Traveling with Expedia is more than just a flight. We offer details about in-flight amenities, baggage policies, and more to ensure a smooth and hassle-free journey. Choose from our variety of airlines and embark on a memorable journey from Chicago to Knoxville.
Beyond the Flight – Exploring Knoxville
With Expedia, your adventure extends beyond the flight. Explore Knoxville at your own pace by renting a car or booking a hotel. Discover hidden gems off the beaten path and create unforgettable memories.
Book Your Flight from Chicago to Knoxville with Confidence
Planning your next great adventure is a breeze with Expedia. Our user-friendly platform, unbeatable prices, and round-the-clock customer support make your travel experience seamless and stress-free. Embark on your journey from Chicago to Knoxville with confidence. Book your travel arrangements with Expedia today.
*Note: Prices may vary based on availability and are subject to change.
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