A bench, a bicycle, and a lake surrounded by trees.

Best Luxury Hotels in Upstate South Carolina

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Check availability on Upstate South Carolina Luxury Hotels

Tonight
16 Sept - 17 Sept
Tomorrow
17 Sept - 18 Sept
This weekend
18 Sept - 20 Sept
Next weekend
25 Sept - 27 Sept

Our top choices for Upstate South Carolina luxury hotels

A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
A modern interior with a fireplace, plush seating, and a stone accent wall.
An outdoor dining area with multiple tables and chairs, large windows, and a view of greenery.
A modern interior with a stone fireplace, seating areas, and a unique ceiling design.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
RM1,430
RM1,620 total
includes taxes & fees
11 Oct - 12 Oct
Grand Bohemian Lodge Greenville, Autograph Collection
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.
A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.
An outdoor patio with wicker furniture, a round table, and a fountain.

2. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
RM974
RM1,081 total
includes taxes & fees
4 Oct - 5 Oct
The Shepherd Hotel Downtown Clemson
A hotel facade with arched windows, a fountain, and a sign for "The Westin."
A lobby with patterned flooring, a grand staircase, and elegant furniture.
A grand lobby with a chandelier, multiple seating areas, and a checkered floor pattern.

3. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
  • Historic luxury awaits in city centre Greenville, with pillowtop beds and attentive service at this architectural gem.
RM731
RM841 total
includes taxes & fees
11 Oct - 12 Oct
The Westin Poinsett Greenville
A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
A bar with multiple shelves of liquor bottles and glasses hanging above.
A modern living room with a fireplace, seating area, and a bar with shelves of bottles.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.

4. Hotel Hartness

Hotel Hartness
Greenville
RM622
RM839 total
includes taxes & fees
4 Oct - 5 Oct
Hotel Hartness
A white, two-story house with a front porch, surrounded by trees and shrubs.
A bedroom with two beds, a TV, and a fireplace.
A dining area with round tables, black chairs, and white tablecloths.
A hallway with a wooden bench, a chair, a cabinet, and a painting on the wall.

5. Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
Pendleton
RM466
RM517 total
includes taxes & fees
15 Oct - 16 Oct
Liberty Hall Bed and Breakfast
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.

6. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
RM658
RM731 total
includes taxes & fees
5 Oct - 6 Oct
The Abernathy of Clemson
A bar area with multiple hanging decorative lights, a counter with bar stools, and a seating area with chairs.
A spacious indoor venue with rows of white chairs adorned with purple sashes, large windows, and a modern ceiling design.
A modern building with a large illuminated logo reading "TOPGOLF" on the facade.
A well-furnished living room with a chandelier, wooden furniture, and a view through a window.

7. Greenville Marriott

Greenville Marriott
Greenville
RM498
RM565 total
includes taxes & fees
27 Sept - 28 Sept
Greenville Marriott
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.
A bedroom with a bed, bedside tables, a ceiling fan, and two windows with blinds.
A modern kitchen with granite countertops, double sinks, and a built-in dishwasher.
A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a granite countertop. There are three white bar stools and two pendant lights.

8. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
RM386
RM437 total
includes taxes & fees
21 Sept - 22 Sept
Mint House Greenville Downtown by Kasa
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.
A bar with a large window view of mountains and a chandelier.
A restaurant with a stone fireplace, hanging crystal chandelier, and multiple dining tables set with white tablecloths and wine glasses.

9. Hotel Domestique

Hotel Domestique
Travelers Rest
RM1,712
RM1,883 total
includes taxes & fees
17 Sept - 18 Sept
Hotel Domestique
A modern building with outdoor seating and a garden.
A two-story house with a dark roof and siding, a front porch with four yellow chairs, and a well-maintained garden with shrubs and mulch.
A modern kitchen with white cabinetry, a wooden dining table, and a black chair. There is a window with a view of greenery outside.
A modern living room with a sofa, coffee table, and dining table. There is a TV mounted on the wall, a coffee machine, and a bookshelf.

10. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
RM926
RM1,356 total
includes taxes & fees
17 Sept - 18 Sept
The Station by Compo Hotels
View all properties

Top Upstate South Carolina Hotel Reviews

Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites

10/10 Excellent
"Excellent breakfast. Nice pool. Very convenient location."
Rudy 2-night trip
Posted 18 hours ago
Best Western Plus Greenville I-385 Inn & Suites
Hyatt Place Greenville/Haywood

Hyatt Place Greenville/Haywood

8/10 Good
"Nice hotel for the price. Big rooms"
Amanda 1-night trip
Posted 18 hours ago
Hyatt Place Greenville/Haywood
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent
"Room was clean, staff was very nice"
Brittany 2-night trip
Posted 2 days ago
Embassy Suites Greenville Golf Resort & Conference Center

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