𝗧𝗢𝗣 𝗛𝗼𝘁𝗲𝗹𝘀 𝗶𝗻 Southern Illinois from RM242 (2026) - Fully Refundable Options

A forested valley with autumn foliage, a rocky cliff, and a sunset.

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Go beyond your typical stay in Southern Illinois

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Our top choices for Southern Illinois hotels

A bar area with a long counter, multiple chairs, and hanging light fixtures.

An indoor swimming pool with a metal ladder, a warning sign about cold weather, and a view of the outside.

A hotel room with two beds, a desk with a flat-screen TV, a chair, and a lamp.

A spacious lobby with a reception desk, seating area, and glass doors leading outside.

1. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Kirstyn

RM448

RM506 total

includes taxes & fees

13 Sept - 14 Sept

A Holiday Inn Express & Suites building with a modern design, featuring a covered entrance and a well-lit facade.

A spacious lobby with a wooden ceiling, a reception desk, and a seating area with a table and chairs.

A hotel room with two beds, a large window, and a wall-mounted lamp.

A multi-story hotel with a brick facade, large windows, and a gated outdoor area.

2. Holiday Inn Express & Suites Mount Vernon by IHG

Mount Vernon

Angela D

RM448

RM506 total

includes taxes & fees

20 Sept - 21 Sept

A hotel lobby with a reception desk, seating area, and a large screen TV.

A Comfort Suites hotel with a spacious parking lot and a modern brick facade.

A brick building with a patio area featuring wicker furniture and a table.

A hotel room with a marble bathtub, a wooden dining table with chairs, a bed with a headboard, and a nightstand with lamps.

3. Comfort Suites Mount Vernon

Mount Vernon

Erica

RM494

RM556 total

includes taxes & fees

13 Sept - 14 Sept

A hotel lobby with a large sofa, armchairs, a Christmas tree, and a patterned carpet.

A modern dining area with round tables and chairs, a green booth seating area, and artwork on the walls.

A Fairfield Inn & Suites by Marriott hotel with a parking lot and a clear sky.

A hotel lobby with a reception desk, a red sofa, a potted plant, and a fireplace.

4. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Mount Vernon

Blake

RM440

RM497 total

includes taxes & fees

30 Aug - 31 Aug

An indoor swimming pool with a view of the outside, a hot tub, and a seating area with tables and chairs.

An outdoor patio area with tables and chairs, large windows, and red umbrellas.

A spacious lobby with high ceilings, a wooden ceiling, and a large wall with vertical panels. There are seating areas with sofas and chairs, and a staircase on the right.

A hotel room with two beds, a desk, a chair, a TV, and a balcony with a view.

5. DoubleTree by Hilton Mt. Vernon

Mount Vernon

Samuel

RM516

RM581 total

includes taxes & fees

3 Sept - 4 Sept

A hotel room with a bed, a desk, a chair, a TV, and a window with curtains.

A hotel room with a desk, a lamp, a flat-screen TV, a telephone, a microwave, and a trash bin.

A parking lot with a Super 8 sign, a white car, and a truck.

6. Super 8 by Wyndham Mt. Vernon IL

Mount Vernon

Matthew W,

RM284

RM323 total

includes taxes & fees

23 Aug - 24 Aug

A spacious lobby with a stone fireplace, a seating area with a sofa and chairs, and a television mounted on the wall.

A dining area with round tables and chairs, a kitchen with a countertop and appliances, and a hallway leading to another room.

A hallway with vending machines and a carpeted floor.

A hotel with a flat facade, multiple windows, and a sign indicating it is a 'SureStay Hotel by Best Western'.

7. SureStay Hotel by Best Western Whittington Rend Lake

Whittington

Vinay

RM327

RM363 total

includes taxes & fees

6 Sept - 7 Sept

A spacious lobby with a beige sectional sofa, a fireplace, and a view of the outside through large glass doors.

A hotel lobby with a large indoor pool, a reception desk, and a seating area.

A modern hotel lobby with a long dining table, bar stools, a sofa, and a fireplace.

A modern living area with a sectional sofa, a fireplace, and a flat-screen TV.

8. Hampton Inn & Suites Effingham

Effingham

Kate

RM493

RM548 total

includes taxes & fees

6 Sept - 7 Sept

A multi-story hotel with a central entrance, illuminated by exterior lights, and a clear sky in the background.

A spacious lobby with a large seating area, a reception desk, and a television.

An indoor swimming pool with clear blue water, surrounded by beige tiled flooring and walls. There are lounge chairs and a small seating area with tables.

A hotel room with two beds, a large window with curtains, a wall-mounted lamp, and a patterned carpet.

9. Best Western Plus Centralia Hotel & Suites

Centralia

Corey

RM602

RM674 total

includes taxes & fees

23 Aug - 24 Aug

A La Quinta hotel with a stone facade, a covered entrance, and a parking lot.

A modern kitchen area with a counter, various appliances, and food display items.

A modern hotel lobby with a large sun-shaped artwork, multiple seating areas, and a patterned rug.

An indoor swimming pool with lounge chairs and a clear view of the pool area.

10. La Quinta Inn & Suites by Wyndham Effingham

Effingham

Alexis

RM405

RM454 total

includes taxes & fees

30 Aug - 31 Aug

A spacious lobby with high ceilings, multiple seating areas, and large windows allowing natural light.

An outdoor patio area with a table and chairs, a red umbrella, and a brick building facade.

An indoor swimming pool with clear water, tiled walls, and a ceiling with square vents.

11. Drury Inn & Suites Marion

Marion

Tara

RM428

RM514 total

includes taxes & fees

20 Sept - 21 Sept

An outdoor patio area with wicker furniture, a stone pillar, and a glass-enclosed dining area.

A hotel room with two beds, a desk, a chair, and a sofa.

A Holiday Inn Express & Suites building with a modern design, featuring a flat roof, large windows, and a landscaped front yard.

A buffet with labeled food items including omelets and cheese.

12. Holiday Inn Express & Suites Salem by IHG

Salem

Todd

RM416

RM466 total

includes taxes & fees

20 Sept - 21 Sept

An indoor swimming pool with a clear view of the surrounding area, including a seating area with chairs and a view of the outdoors through large windows.

A spacious dining area with a long wooden table, multiple chairs, and pendant lighting.

A hotel room with a desk, two monitors, a keyboard, and a mouse.

A Best Western hotel with a modern facade, a parking lot, and a clear sky.

13. Best Western Delta Inn

Effingham

Chris

RM357

RM400 total

includes taxes & fees

30 Aug - 31 Aug

An outdoor patio area with a fire pit, seating, and a covered section.

A grocery store interior with refrigerated sections, shelves stocked with snacks, and a checkout area.

A modern gym with various exercise equipment, including dumbbells, benches, and a squat rack.

A modern breakfast bar with a coffee machine, fruit display, and various food items.

14. Home2 Suites By Hilton Effingham

Effingham

Tim

RM527

RM590 total

includes taxes & fees

6 Sept - 7 Sept

A modern spa room with a large hot tub, a glass wall with a reflective pattern, and a ceiling with a skylight.

A hotel lobby with a marble floor, a reception desk, a sign for 'Restrooms', and a large chandelier.

A hotel lobby with a marble floor, a reception area with a '12 & VINE' sign, and a dining area with orange chairs and chandeliers.

A casino interior with slot machines, a large chandelier, and a carpeted floor.

15. Walker's Bluff Casino Resort

Carterville

Sheila

RM505

RM561 total

includes taxes & fees

30 Aug - 31 Aug

A lobby with a blue sofa, a brown leather chair, a round coffee table, and a fireplace.

A gym with treadmills, ellipticals, and a mirrored wall.

A hotel room with a large bed, two bedside lamps, a chair, a mirror, and a framed picture on the wall.

A spacious dining area with multiple tables and chairs, a colorful carpet, and wooden pillars.

16. Fairfield Inn & Suites Marriott Effingham

Effingham

Tyler

RM374

RM415 total

includes taxes & fees

30 Aug - 31 Aug

A Country Inn & Suites building with a covered entrance and a sign.

A building with a green roof, white columns, and a glass entrance.

A restaurant with wooden tables and chairs, a coffee bar with various appliances, and a TV mounted on the wall.

An indoor swimming pool with clear lane markings, a lifeguard chair, and a no diving sign.

17. Country Inn & Suites by Radisson, Effingham, IL

Effingham

Jeremiah

RM344

RM382 total

includes taxes & fees

20 Sept - 21 Sept

A modern living room with a fireplace, blue sofa, red chairs, and a flat-screen TV mounted on a textured wall.

A hotel room with a blue armchair, a sofa, a bed, a desk, a television, and a window.

A hotel reception area with a long wooden counter, coffee machines, and a wall with framed pictures.

18. Comfort Inn & Suites Greenville I-70

Greenville

Alan

RM401

RM445 total

includes taxes & fees

30 Aug - 31 Aug

An outdoor seating area with a fire pit, surrounded by wooden chairs and a view of a sunset over a landscaped garden.

A modern bathroom with a grey cabinet, two lamps, a round mirror, and an elevator.

A hotel room with a large bed, a wooden headboard, a nightstand, a desk, a chair, and a painting on the wall.

A modern living room with a grey sofa, two blue armchairs, a coffee table, and a TV mounted on the wall.

19. Best Western Plus Parkside Inn & Suites

Olney

Richard

RM511

RM568 total

includes taxes & fees

31 Aug - 1 Sept

A modern lobby with a sofa, chairs, a coffee table, and a reception desk.

A restaurant with round tables and chairs, wooden floors, and artwork on the walls.

A hotel room with a bed, a desk with a chair, a small table, a lamp, and a large window with curtains.

20. Fairfield by Marriott Inn & Suites Mattoon

Mattoon

Stephen

RM468

RM525 total

includes taxes & fees

6 Sept - 7 Sept

View all properties

Holiday Rentals in Southern Illinois

Cottage

A covered porch with blue plastic chairs, a ceiling fan, and large windows offering a view of the outdoors.

A kitchen with wooden cabinets, a microwave, a dishwasher, and a dining area with chairs and a table.

A single-story house with a stone foundation and a gabled roof, surrounded by a small lawn and a wooden fence.

A bedroom with a bed, a nightstand, a mirror, a ceiling fan, and a door leading to a bathroom.

Harrisburg Home w/ Private Yard + Screened Porch!

Harrisburg

"We love how accommodating, helpful and responsive Hollie and Clayton were. The rental had everything we needed and then some. Very clean, cozy and comfortable. We chose this location, because it was close to the different parks and trails we had visited. Thank you, Hollie and Clayton, for being such gracious hosts."

Cottage

A modern kitchen with dark cabinets, a round dining table, and a tufted bench.

A bedroom with a bed, a chair, a window, and two framed pictures on the wall.

A modern living room with a flat-screen TV, wooden entertainment unit, leather sofa, and a dining table.

Peaceful Robinson Home w/ Yard, Near Golf Courses!

Robinson

Cottage

A modern kitchen with white cabinetry, a coffee maker, a sink, a dishwasher, and a built-in oven.

A modern kitchen with white cabinets, a wooden dining table, and black chairs.

A living room with a beige sectional sofa, a wooden coffee table, a patterned rug, and a small side table with a lamp.

A two-story house with a well-maintained lawn and patio furniture.

Country Home Near EIU & Lake Charleston!

Charleston

"Property was very clean and beautifully decorated in a farmhouse style. Very cozy and comfortable! Came stocked with everything you would need. We had fun at nearby Aikman Wildlife Adventure in Arcola, Kayaking in Lake Charleston, hiking in Fox Ridge State Park a visit to Amish country in Arthur, IL. The kitchen, living and dining room were very spacious! The bathroom was very tiny so if staying with 4 adults - be prepared for this. Also there was a strange odor right outside the front entry...

Apartment

A wooden deck with a ramp leading to a covered area, a small window, and a metal chair.

A spacious kitchen with wooden cabinets, a dining table with chairs, and an air conditioning unit.

A modern kitchen with wooden cabinets, a dining table with chairs, and a ceiling fan.

A dining area with a wooden table and chairs, a kitchen with wooden cabinets, and a living area with a sofa and a coffee table.

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Murphysboro

"This is a very clean and nice apartment within a very close drive to the Kinkaid boat launch. Easy to locate and can fit a car with a boat in tow no problem. This spot was also much more quiet than the campground or RV spots nearby. They have a great porch and a grill and we didn’t bring something for it which made me sad. "

Cottage

A living room with a fireplace, leather sofas, and a clock on the wall.

A bedroom with a bed, wooden walls, a welcome sign, a television, and a door.

A modern kitchen with wooden cabinets, a white refrigerator, and a microwave. There is a dining area with a table and chairs, and a living room with a couch and a fireplace.

A room with a wooden wall, a window with a view of a deck and outdoor area, and a potted plant with flowers on a table.

Illinois Vacation Rental Home: Pets Welcome

Palestine

Cottage

A long, narrow hallway with wooden floors and large windows.

A modern kitchen with a stainless steel refrigerator, oven, and dishwasher. There is a wooden dining table and a brick accent wall.

A single-story house with a front porch, a central entrance, and a small staircase leading to the door.

A modern kitchen with white cabinets, a stainless steel refrigerator, and a tiled floor.

Cozy Anna Home Near Southern Illinois Attractions!

Anna

"Good communication with the owners. Nice perks such as coffee, tea, and hygiene items."

Cottage

A covered porch with a 'WELCOME' sign, wooden chairs, and a small table.

A modern kitchen with a dining area, stainless steel appliances, and a welcome sign.

A modern living room with a grey sofa set, a coffee table, and a dining area with a table and chairs.

A living room with a sofa, coffee table, TV stand, and a ceiling fan.

Mins to Local Attractions: Pet Friendly w/ Yard!

Casey

"Property was very clean and quiet, will definitely schedule for next family reunion."

Cottage

A wooden deck with a ceiling fan, outdoor furniture, and a view of a garden.

A modern kitchen with wooden cabinets, stainless steel appliances, and a central island with bar stools.

A wooden cabin with a porch, surrounded by a grassy yard and trees.

A wooden cabin with a porch, surrounded by trees and grass.

Beautiful Makanda Cabin in Shawnee National Forest

Makanda

"It was very peaceful and relaxing. "

See all holiday rentals

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

9.8/10 (63 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

See properties

O'Fallon Family Sports Park

8.6/10 (137 reviews)

This sports complex features premium turf fields, splash pads, and fishing ponds in a family-friendly setting. Watch tournaments or enjoy the scenic walking trail that winds around natural areas.

See properties

World Wide Technology Raceway

9.0/10 (2 reviews)

Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

See properties

Harrah's Metropolis

8.0/10 (310 reviews)

This riverside casino offers over 600 slot machines and 17 table games along the scenic Ohio River. Join the rewards programme to maximise your experience while enjoying Southern classics at the on-site restaurants.

See properties

Learn more about Southern Illinois

Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.

See all hotels in Southern Illinois

Top Southern Illinois Hotel Reviews

Country Inn & Suites by Radisson, Effingham, IL

8/10 Good

"Someone was smoking weed. We could smell it when we came back in the evening from supper. Not on our floor, but the elevator stunk. The carpet felt damp,"

Best Western St. Louis Fairview Heights

10/10 Excellent

"Everything is great 👍 clean rooms food is great the staff is very nice 👌 best place to stay in O'Fallon Illinois."

Motel 6 Caseyville, IL - Caseyville Il

10/10 Excellent

"Great place to stay it was clean and staff was helpful!"

Drury Inn & Suites St. Louis Fairview Heights

10/10 Excellent

"Easy parking, dinner and breakfast great"

Country Inn & Suites by Radisson, Fairview Heights, IL

10/10 Excellent

"Me and my sister had a good time. We enjoyed our stay. We ready to go back again and just got home."

Drury Plaza Hotel Mt. Vernon

10/10 Excellent

"Because of traffic due to a car accident, we got there too late for the kickback. So the staff helped us decide on a good place to eat that evening."

Holiday Inn Express Metropolis by IHG

10/10 Excellent

"Very friendly"

Baymont by Wyndham Effingham

10/10 Excellent

"All good"

Holiday Inn Express & Suites Mount Vernon by IHG

10/10 Excellent

"Pool was very small, too small for our normal pool exercise routine."

More cheap stays in Southern Illinois

Super 8 by Wyndham O'Fallon

1100 Eastgate Dr O'Fallon IL

RM220

RM253 total

31 Aug - 1 Sept

includes taxes & fees

6.6/10 (1,081 reviews)

Baymont by Wyndham Effingham

1811 W Fayette Avenue Effingham IL

RM292

RM324 total

30 Aug - 31 Aug

includes taxes & fees

8.2/10 Very good! (1,009 reviews)

Best Western St. Louis Fairview Heights

150 Ludwig Dr Fairview Heights IL

RM323

RM365 total

30 Aug - 31 Aug

includes taxes & fees

7.4/10 Good! (96 reviews)

Baymont by Wyndham Marion

2608 W Main St Marion IL

RM331

RM397 total

1 Sept - 2 Sept

includes taxes & fees

8.4/10 Very good! (1,092 reviews)

Holiday Inn Express Metropolis by IHG

2179 East 5th Street Metropolis IL

RM400

RM444 total

20 Sept - 21 Sept

includes taxes & fees

8.8/10 Excellent! (1,018 reviews)

Comfort Suites Mount Vernon

404 South 44th Street Mount Vernon IL

RM494

RM556 total

13 Sept - 14 Sept

includes taxes & fees

9/10 Wonderful! (1,077 reviews)

Southern Illinois hotels from RM242

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Southern Illinois

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southern Illinois hotels

1. Drury Plaza Hotel Mt. Vernon

2. Holiday Inn Express & Suites Mount Vernon by IHG

3. Comfort Suites Mount Vernon

4. Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

5. DoubleTree by Hilton Mt. Vernon

6. Super 8 by Wyndham Mt. Vernon IL

7. SureStay Hotel by Best Western Whittington Rend Lake

8. Hampton Inn & Suites Effingham

9. Best Western Plus Centralia Hotel & Suites

10. La Quinta Inn & Suites by Wyndham Effingham

11. Drury Inn & Suites Marion

12. Holiday Inn Express & Suites Salem by IHG

13. Best Western Delta Inn

14. Home2 Suites By Hilton Effingham

15. Walker's Bluff Casino Resort

16. Fairfield Inn & Suites Marriott Effingham

17. Country Inn & Suites by Radisson, Effingham, IL

18. Comfort Inn & Suites Greenville I-70

19. Best Western Plus Parkside Inn & Suites

20. Fairfield by Marriott Inn & Suites Mattoon

Holiday Rentals in Southern Illinois

Harrisburg Home w/ Private Yard + Screened Porch!

Peaceful Robinson Home w/ Yard, Near Golf Courses!

Country Home Near EIU & Lake Charleston!

Murphysboro Retreat w/ Deck Near Kinkaid Lake!

Illinois Vacation Rental Home: Pets Welcome

Cozy Anna Home Near Southern Illinois Attractions!

Mins to Local Attractions: Pet Friendly w/ Yard!

Beautiful Makanda Cabin in Shawnee National Forest

Stay near popular Southern Illinois attractions

Garden of the Gods Recreation Area

O'Fallon Family Sports Park

World Wide Technology Raceway

Harrah's Metropolis

Learn more about Southern Illinois

Top Southern Illinois Hotel Reviews

Country Inn & Suites by Radisson, Effingham, IL

Best Western St. Louis Fairview Heights

Motel 6 Caseyville, IL - Caseyville Il

Drury Inn & Suites St. Louis Fairview Heights

Country Inn & Suites by Radisson, Fairview Heights, IL

Drury Plaza Hotel Mt. Vernon

Holiday Inn Express Metropolis by IHG

Baymont by Wyndham Effingham

Holiday Inn Express & Suites Mount Vernon by IHG

More cheap stays in Southern Illinois

Super 8 by Wyndham O'Fallon

Baymont by Wyndham Effingham

Best Western St. Louis Fairview Heights

Baymont by Wyndham Marion

Holiday Inn Express Metropolis by IHG

Comfort Suites Mount Vernon

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