Sikeston

Travel Guide

A tree with sunlight filtering through its leaves, creating a warm glow.
A person walking through a cornfield.
A building with three tall chimneys, surrounded by blooming trees with pink and white flowers.
A sign for Lambert's, a place of worship.
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
The price is RM384 per night from 1 Nov to 2 Nov
RM384
RM441 total
1 Nov - 2 Nov
includes taxes & fees
Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...
Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
The price is RM271 per night from 1 Nov to 2 Nov
RM271
RM309 total
1 Nov - 2 Nov
includes taxes & fees
Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...
Days Inn and Suites by Wyndham Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
The price is RM389 per night from 22 Nov to 23 Nov
RM389
RM442 total
22 Nov - 23 Nov
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ...
9/10 Wonderful! (649 reviews)
"Great hotel, clean spacious room, good breakfast choice"

Reviewed on 22 Oct 2026

Hampton Inn Sikeston
See all 319 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Urban Lofts

Urban Lofts

3 out of 5
102 N Jackson St Perryville MO
Stay at this aparthotel in Perryville. Enjoy free Wi-Fi, free parking and dry cleaning or laundry services. Popular attractions Feltz Street Park and Perryville ...
9.4/10 Exceptional! (22 reviews)
"Beautiful, clean property in the heart of city center. Many options for food and shopping within short walking distance."

Reviewed on 11 Jun 2026

Urban Lofts
The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel

2 out of 5
112 W Ste Maries St Perryville MO
Stay at this aparthotel in Perryville. Enjoy free Wi-Fi, free parking and bathrobes. Popular attractions Feltz Street Park and Perryville Country Club are located ...
9.2/10 Wonderful! (10 reviews)
"The property was beautiful. However it was listed on Expedia as having a sofa bed which we required. It did not have a sofa bed. It didn’t even have a sofa, it had a love seat. Pretty hard for someone to sleep on. Also, the bar/nightclub attached will keep you up till closing. Very loud. Check with ..."

Reviewed on 18 Oct 2026

The Atrium - A Boutique Hotel
See all properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)
You can spend time studying the exhibits at Sikeston Depot Museum during your travels in Sikeston. While in this family-friendly area, you can savour the top-notch restaurants.
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