Hotels in Santo Spirito, Florence

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santo Spirito hotels

Mamo Florence - Bice & Krizia Apartments

Mamo Florence - Bice & Krizia Apartments
Santo Spirito
9.0 out of 10, Wonderful, (2 reviews)
"Nice stay. Location was slightly off the beaten track, which we liked. Staff were responsive to us on the phone immediately. Nice flat."
United States
Christopher Pat
The price is RM316
RM815 total
includes taxes & fees
3 Mar - 4 Mar
Mamo Florence - Bice & Krizia Apartments

Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie
Santo Spirito
8.8 out of 10, Excellent, (197 reviews)
"The room was clean a d comfortable, and the staff was very courteous and helpful. The location was also good with most attractions being a 30 to 40 minute walk or less."
United States
Roger
Foresteria Valdese di Firenze - Casa per Ferie

Torre di Bellosguardo

Torre di Bellosguardo
4.0 star property
Santo Spirito
9.0 out of 10, Wonderful, (103 reviews)
"Beautiful property and wonderful staff."
United States
Brad
The price is RM1,475
RM1,687 total
includes taxes & fees
10 Mar - 11 Mar
Torre di Bellosguardo

La Fonderia Firenze

La Fonderia Firenze
Santo Spirito
9.6 out of 10, Exceptional, (173 reviews)
"The room was beautiful and clean, the staff was pleasant, breakfast was fantastic, 10/10"
United States
Dan
The price is RM412
RM508 total
includes taxes & fees
1 Mar - 2 Mar
La Fonderia Firenze

Ottantotto Firenze

Ottantotto Firenze
Santo Spirito
9.6 out of 10, Exceptional, (169 reviews)
"Great location and extremely charming!"
United States
Brook
The price is RM766
RM907 total
includes taxes & fees
19 Mar - 20 Mar
Ottantotto Firenze

AdAstra Suites

AdAstra Suites
Santo Spirito
9.8 out of 10, Exceptional, (225 reviews)
"Wonderful room and everyone who worked at the hotel couldn’t be more helpful. Peaceful and calm, would thoroughly recommend."
United Kingdom
James
The price is RM882
RM1,034 total
includes taxes & fees
1 Mar - 2 Mar
AdAstra Suites

Oltrarno Splendid

Oltrarno Splendid
Santo Spirito
10.0 out of 10, Exceptional, (107 reviews)
"It was a great stay. The renovation style is very tasteful. "
Singapore
Maoying
The price is RM700
RM834 total
includes taxes & fees
2 Mar - 3 Mar
Oltrarno Splendid

L'Antica Porta Boutique B&B

L'Antica Porta Boutique B&B
Santo Spirito
9.0 out of 10, Wonderful, (22 reviews)
"Very goord place to stay"
United States
Victor
The price is RM263
RM345 total
includes taxes & fees
1 Mar - 2 Mar
L'Antica Porta Boutique B&B

La Torre Del Cestello

La Torre Del Cestello
Santo Spirito
9.0 out of 10, Wonderful, (238 reviews)
"Great location and great rooms"
United States
David
La Torre Del Cestello

SPIRIT OF FLORENCE Boutique Rooms

SPIRIT OF FLORENCE Boutique Rooms
Santo Spirito
10.0 out of 10, Exceptional, (25 reviews)
"My husband and I enjoyed our stay here! Large rooms and bathrooms, wonderful location, and great staff! "
United States
Christina
The price is RM793
RM928 total
includes taxes & fees
1 Mar - 2 Mar
SPIRIT OF FLORENCE Boutique Rooms

Mamo Florence - Margot Apartment

Mamo Florence - Margot Apartment
Santo Spirito
10.0 out of 10, Exceptional, (2 reviews)
"Good"
Italy
Lynette
The price is RM394
RM956 total
includes taxes & fees
1 Mar - 2 Mar
Mamo Florence - Margot Apartment

Hotel Horto Convento

Hotel Horto Convento
4.0 star property
Santo Spirito
9.8 out of 10, Exceptional, (622 reviews)
"Wonderful place, super clean, very nice staff and wonderful breakfast. Also great location for beautiful walks not too close to areas overcrowded by tourists!"
United States
Gianmaria
The price is RM482
RM595 total
includes taxes & fees
8 Mar - 9 Mar
Hotel Horto Convento

Santo Spirito Bright Flat by Mmega

Santo Spirito Bright Flat by Mmega
Santo Spirito
The price is RM350
RM807 total
includes taxes & fees
11 Mar - 12 Mar
Santo Spirito Bright Flat by Mmega

1900 Artevita

1900 Artevita
Santo Spirito
8.8 out of 10, Excellent, (178 reviews)
"Our stay here was wonderful! The host was so pleasant and the view from the terrace was beautiful. The location was in a great spot for enjoying the Florentine neighborhoods, and close to many of the restaurants recommended to us. We would stay here again in a heartbeat."
United States
Bianca
1900 Artevita

Palazzo Mannaioni Suites

Palazzo Mannaioni Suites
4.0 star property
Santo Spirito
9.2 out of 10, Wonderful, (1,086 reviews)
"Clean room, great staff, excellent location."
United States
Joseph
Palazzo Mannaioni Suites

Bella Vista City View by MMega

Bella Vista City View by MMega
Santo Spirito
9.6 out of 10, Exceptional, (5 reviews)
"Fantastic apartment on the best, local square for casual dinners and drinks in the less touristic area."
Denmark
Michael Valentin
The price is RM525
RM1,091 total
includes taxes & fees
27 Feb - 28 Feb
Bella Vista City View by MMega

Appartamenti degli Artisti by Mmega

Appartamenti degli Artisti by Mmega
Santo Spirito
8.4 out of 10, Very good, (30 reviews)
"We stayed here in November and had a wonderful experience. The location worked perfectly for my husband and I, close enough to the center to get everywhere easily, yet set in a quiet residential part of Florence where we could feel the local rhythm of the city. The staff who look after the house were all very easy to communicate with. The whole stay was smooth and comfortable. We truly enjoyed our time here!"
United States
Ray
The price is RM306
RM759 total
includes taxes & fees
27 Feb - 28 Feb
Appartamenti degli Artisti by Mmega

Palazzo D'Oltrarno - Residenza D'Epoca

Palazzo D'Oltrarno - Residenza D'Epoca
Santo Spirito
9.6 out of 10, Exceptional, (47 reviews)
"Excellent place to stay!"
United States
Diane
The price is RM501
RM606 total
includes taxes & fees
9 Mar - 10 Mar
Palazzo D'Oltrarno - Residenza D'Epoca

Flospirit - Oltrarno

Flospirit - Oltrarno
Santo Spirito
8.0 out of 10, Very good, (11 reviews)
"I will definitely recommend this place to friends and family visiting Florence. It has a fantastic location and a wonderful apartment!"
United States
Kelly
The price is RM365
RM708 total
includes taxes & fees
27 Feb - 28 Feb
Flospirit - Oltrarno

Borgo San Frediano Hideaway

Borgo San Frediano Hideaway
Santo Spirito
Borgo San Frediano Hideaway
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas for the activities you enjoy most.

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza di Santa Maria Novella or Via de' Calzaiuoli while you're exploring the neighbourhood.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Santo Spirito Hotel Reviews

Frequently asked questions

What is Santo Spirito like?
Santo Spirito is a trendy neighbourhood known for its stunning river views. Make sure that you visit Piazza Santo Spirito and Arno River as part of your Santo Spirito travel plans.
What's a favourite place to stay in Santo Spirito?
Based on Expedia customer reviews, Oltrarno Splendid is the highest ranked property in Santo Spirito. This B&B is a short 7-minute walk from Piazza di Santa Maria Novella, and it offers free breakfast and free WiFi. Other favourite options in the area include SPIRIT OF FLORENCE Boutique Rooms and La Fonderia Firenze.
How many hotels can I expect to find in the Santo Spirito area?
Expedia has 496 hotels and other accommodation options in Santo Spirito to choose from, making this an ideal home base for exploring the greater Florence area.
If I need to cancel my hotel reservation in Santo Spirito, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then filter by "fully refundable" to get top deals in Santo Spirito.
What can I see and do in this Florence neighbourhood?
Spend some time exploring the natural setting of Santo Spirito with a visit to Arno River and Torrigiani Garden. As you're discovering the neighbourhood, Piazza Santo Spirito and Piazza del Carmine are some other places worth a visit. A few places to visit in the area around Santo Spirito include Piazza di Santa Maria Novella, Santa Maria della Carmine and Brancacci Chapel. When you're sightseeing in Florence, Il Nabucco di Matteo Gabellini and Teatro Comunale Florence are also worth a stop.

Explore a world of travel with Expedia