Hotels in Santo Spirito, Florence

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
16 Nov - 17 Nov
Tomorrow
17 Nov - 18 Nov
Next weekend
21 Nov - 23 Nov
In two weeks
28 Nov - 30 Nov

Filter by

Guest rating
Guest rating
Star rating

Top 10 Hotels in Santo Spirito, Florence

Lobby
Hotel Horto Convento

Hotel Horto Convento

4.0 star property
Santo Spirito
9.8 out of 10, Exceptional, (590)
"Excellent location and very helpful staff. "
United Kingdom
Susan Katarina
The price is RM488
RM604 total
includes taxes & fees
9 Dec - 10 Dec
Hotel Horto Convento
Interior
Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie

Santo Spirito
8.8 out of 10, Excellent, (192)
"The staff was very helpful and room was clean "
United States
Cinda
Foresteria Valdese di Firenze - Casa per Ferie
Lobby
Casa Santo Nome di Gesù

Casa Santo Nome di Gesù

Santo Spirito
8.8 out of 10, Excellent, (337)
"I always enjoy my stay here. Nicely located, pleasant breakfast, terrific courtyard, nicely priced. "
United States
Marcie
Casa Santo Nome di Gesù
Front of property
Hotel Firenze 2000

Hotel Firenze 2000

2.0 star property
Santo Spirito
7.2 out of 10, Good, (189)
"The staff was wonderful and very helpful; 24 hr service ! The room was very clean and breakfast was plentiful. Great location if you don’t mind a short walk to the historic town center ; would definitely recommend."
Canada
Josee
The price is RM326
RM402 total
includes taxes & fees
14 Dec - 15 Dec
Hotel Firenze 2000
Interior detail
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4.0 star property
Santo Spirito
9.2 out of 10, Wonderful, (1067)
"Clean and great staff"
United States
lauren
Palazzo Mannaioni Suites
Premium bedding, down duvets, in-room safe, desk
La Torre Del Cestello

La Torre Del Cestello

Santo Spirito
9.0 out of 10, Wonderful, (222)
"Great location and great rooms"
United States
David
La Torre Del Cestello
Minibar, in-room safe, soundproofing, free WiFi
Oltrarno Splendid

Oltrarno Splendid

Santo Spirito
10.0 out of 10, Exceptional, (95)
"Amazing and kind staff. Delicious breakfast. "
United States
Anonymous traveller
The price is RM821
RM970 total
includes taxes & fees
1 Dec - 2 Dec
Oltrarno Splendid
Front of property
Palazzo D'Oltrarno - Residenza D'Epoca

Palazzo D'Oltrarno - Residenza D'Epoca

Santo Spirito
9.4 out of 10, Exceptional, (46)
"Excellent place to stay!"
United States
Diane
The price is RM492
RM599 total
includes taxes & fees
17 Nov - 18 Nov
Palazzo D'Oltrarno - Residenza D'Epoca
Free daily buffet breakfast
La Fonderia Firenze

La Fonderia Firenze

Santo Spirito
9.6 out of 10, Exceptional, (172)
"Breakfast outside was lovely"
United States
Kenneth
The price is RM387
RM483 total
includes taxes & fees
18 Nov - 19 Nov
La Fonderia Firenze
Reception
Della Calza Spa & Foresteria

Della Calza Spa & Foresteria

Santo Spirito
The price is RM1,091
RM1,258 total
includes taxes & fees
17 Nov - 18 Nov
Della Calza Spa & Foresteria
Down duvets, in-room safe, individually decorated, desk
AdAstra Suites

AdAstra Suites

Santo Spirito
9.8 out of 10, Exceptional, (219)
"Staff was absolutely wonderful!!! "
United States
Trisha
The price is RM743
RM884 total
includes taxes & fees
4 Dec - 5 Dec
AdAstra Suites
Seasonal outdoor pool
Torre di Bellosguardo

Torre di Bellosguardo

4.0 star property
Santo Spirito
9.0 out of 10, Wonderful, (103)
"We absolutely adored this hotel in every way. The views were not to be believed. It was only a 10 to 15 taxi to anywhere in Florence. Heavenly. My only suggestion is please add a shower curtain to the bath/ shower area so the water doesn’t spray all over the bathroom. Otherwise, this place will exceed anyone’s expectations and dreams! GRATZI! "
United States
Amy
The price is RM1,544
RM1,766 total
includes taxes & fees
17 Nov - 18 Nov
Torre di Bellosguardo
Lounge
Hotel Palazzo Guadagni

Hotel Palazzo Guadagni

3.0 star property
Santo Spirito
9.0 out of 10, Wonderful, (200)
"Nice and elegant, good breakfast options"
United States
David
The price is RM726
RM856 total
includes taxes & fees
17 Nov - 18 Nov
Hotel Palazzo Guadagni
22-inch flat-screen TV with digital channels, TV
1900 Artevita

1900 Artevita

Santo Spirito
8.8 out of 10, Excellent, (176)
"Great location; was easily accessible to the shopping district..museums..had a comfortable stay..highly recommend "
United States
mary jane
The price is RM339
RM431 total
includes taxes & fees
17 Nov - 18 Nov
1900 Artevita
Exterior detail
Residenza D'Epoca Al Numero 8

Residenza D'Epoca Al Numero 8

Santo Spirito
8.8 out of 10, Excellent, (137)
"I like everything in this hotel "
United States
claudia
Residenza D'Epoca Al Numero 8
Courtyard view
Drom Florence Rooms & Apartments

Drom Florence Rooms & Apartments

Santo Spirito
9.8 out of 10, Exceptional, (132)
"We enjoyed our stay in florence. The service was wonderful and it was out of the way of the noisiness. That was many surrounding cafés and restaurants as well as grocery stores and laundromat. The bed was extremely comfortable and the bathroom was equipped. Well, the service was amazing."
United States
victoria
Drom Florence Rooms & Apartments
Garden
Ottantotto Firenze

Ottantotto Firenze

Santo Spirito
9.6 out of 10, Exceptional, (169)
"Best small hotel in Florence!!! Great breakfast service with the nicest staff and cooks"
United States
Carlos
The price is RM936
RM1,097 total
includes taxes & fees
17 Nov - 18 Nov
Ottantotto Firenze
Courtyard view
Ostello Tasso

Ostello Tasso

Santo Spirito
9.0 out of 10, Wonderful, (33)
"Loved this place, 100/10!! Super safe neighborhood, close to town (15-20 minute walk). Best part was air conditioning. Host was very helpful in recommending places to visit! Highly recommend! We were 2 young females and felt very safe here "
United States
Isabella
Ostello Tasso
Reception
Hostel Santa Monaca

Hostel Santa Monaca

Santo Spirito
8.0 out of 10, Very good, (60)
"I found it easy to move around and walked everywhere. Staff super friendly. Ten people in one room was a bit much, but overall comfortable. Thank you.!"
Canada
Alma
Hostel Santa Monaca
1 bedroom, in-room safe, desk, free WiFi
L'Antica Porta Boutique B&B

L'Antica Porta Boutique B&B

Santo Spirito
8.8 out of 10, Excellent, (18)
"Clean and bright Beautiful room just a little confused about calling it a Bed and Breakfast? No breakfast? "
United States
christopher
The price is RM358
RM451 total
includes taxes & fees
17 Nov - 18 Nov
L'Antica Porta Boutique B&B
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santo Spirito

Find the best Santo Spirito areas for the activities you enjoy most.

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Via de' Calzaiuoli or Giotto's Campanile while you're exploring the neighbourhood.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. The New Florence Opera House is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Uffizi Gallery showing street scenes as well as a large group of people

San Giovanni

If you're spending some time in San Giovanni, Uffizi Gallery and Cathedral of Santa Maria del Fiore are top sights worth seeing.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Santo Spirito Hotel Reviews

Hotel Horto Convento

Hotel Horto Convento

10/10 Excellent
"Excellent staff, so friendly and helpful. Lovely hotel in a great location. "
Emma 3-night trip
Posted 9 days ago
Hotel Horto Convento

Explore a world of travel with Expedia

Frequently asked questions

What is Santo Spirito like?
Santo Spirito is a trendy neighbourhood known for its stunning river views. Make sure that you visit Porta Romana and Piazza Santo Spirito as part of your Santo Spirito travel plans.
What's a favourite place to stay in Santo Spirito?
Based on Expedia customer reviews, Oltrarno Splendid is the highest ranked property in Santo Spirito. This B&B is a short 7-minute walk from Piazza di Santa Maria Novella, and it offers free breakfast and free WiFi. Other favourite options in the area include SPIRIT OF FLORENCE Boutique Rooms and Ottantotto Firenze.
How many hotels can I expect to find in the Santo Spirito area?
Expedia has 478 hotels and other accommodation options in Santo Spirito to choose from, making this an ideal home base for exploring the greater Florence area.
If I need to cancel my hotel reservation in Santo Spirito, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then filter by "fully refundable" to get top deals in Santo Spirito.
What can I see and do in this Florence neighbourhood?
Spend some time exploring the natural setting of Santo Spirito with a visit to Arno River and Torrigiani Garden. As you're discovering the neighbourhood, Porta Romana and Piazza Santo Spirito are some other places worth a visit. A few places to visit in the area around Santo Spirito include Piazza del Carmine, Santa Maria della Carmine and Brancacci Chapel. When you're sightseeing in Florence, Il Nabucco di Matteo Gabellini and Teatro Comunale Florence are also worth a stop.