Default HTG hotel image

Santa Cruz Vacation Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
28 Aug - 30 Aug
In two months
9 Oct - 11 Oct
In three months
6 Nov - 8 Nov
In four months
4 Dec - 6 Dec

Our top choices for Santa Cruz holiday rentals

Living area

1. Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.4 out of 10, Exceptional, (43 reviews)
"Exelente servicio"
United States
Ernesto
The price is RM246
RM308 total
17 Aug - 18 Aug
Skyline Ecoliving
Restaurant

2. Edificio Helena

Edificio Helena
3.0 star property
Medellín
8.8 out of 10, Excellent, (69 reviews)
"Awesome breakfast, great location. Great host"
United States
James
The price is RM173
RM173 total
10 Sept - 11 Sept
Edificio Helena
Coffee shop

3. B 48 Living by B Rent

B 48 Living by B Rent
4.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (22 reviews)
"I love the people & I love the area. One of the best place to stay in Medellin. "
United States
Lusene
The price is RM247
RM247 total
13 Aug - 14 Aug
B 48 Living by B Rent
1 bedroom, premium bedding, down duvets, in-room safe

4. Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.2 out of 10, Wonderful, (290 reviews)
"Excellent place to stay with family and friends!"
Canada
Jose
The price is RM284
RM284 total
14 Aug - 15 Aug
Portal del Rodeo ApartaHotel - Arkadia Mall
Reception

5. Metropolitan Living by HOUSY

Metropolitan Living by HOUSY
4.0 star property
San Diego
8.8 out of 10, Excellent, (81 reviews)
"Good😀😀😀😀"
United States
Percy
The price is RM221
RM311 total
27 Aug - 28 Aug
Metropolitan Living by HOUSY
Front of property

6. Nomadic Boutique Living and Experience Center

Nomadic Boutique Living and Experience Center
4.0 star property
El Poblado
9.8 out of 10, Exceptional, (29 reviews)
"The day staff was amazing, the included breakfast was the best I’ve had! The space was perfect!"
United States
Carolina
The price is RM224
RM256 total
26 Aug - 27 Aug
Nomadic Boutique Living and Experience Center
Living area

7. Loft 43

Loft 43
3.0 star property
Laureles
8.6 out of 10, Excellent, (33 reviews)
"Fabulous room with floor to ceiling windows, comfortable bed, hot water in the shower and a strong wifi connection. Close to Estadio metro station and La Setenta for food and nightlife. Staff were friendly and check-in was fast. Light sleepers might find the neighborhood a bit loud. There are many local restaurants along Calle 43 (just head away from La 70) for lunch and dinner."
United States
Daniel
The price is RM240
RM240 total
26 Aug - 27 Aug
Loft 43
Restaurant

8. Hotel Distrito 70 Living

Hotel Distrito 70 Living
3.0 star property
Laureles - Estadio
9.6 out of 10, Exceptional, (5 reviews)
"Clean room, the breakfast was good but it was in another location"
United States
Ricardo
The price is RM193
RM193 total
3 Sept - 4 Sept
Hotel Distrito 70 Living
Free WiFi

9. hotel civitas medellin

hotel civitas medellin
2.5 star property
La Candelaria
8.8 out of 10, Excellent, (3 reviews)
"Hotel in a good location, comfortable and has a great staff."
United States
Valencia
The price is RM127
RM127 total
15 Aug - 16 Aug
hotel civitas medellin
Full-sized fridge, microwave, oven, stovetop

10. Luxury Suites Prana By Cadissa

Luxury Suites Prana By Cadissa
5.0 star property
Laureles - Estadio
9.4 out of 10, Exceptional, (54 reviews)
"It was very easy to check in and out. The apartment had everything we needed to be comfortable. The location was great. We were able to walk around and felt very safe. I highly recommend it if you are looking for an affordable place with good customer service and cleanliness."
United States
Mahely
The price is RM386
RM562 total
13 Aug - 14 Aug
Luxury Suites Prana By Cadissa
Premium bedding, down duvets, minibar, free WiFi

11. Hotel Moore 45

Hotel Moore 45
4.0 star property
Buenos Aires
8.8 out of 10, Excellent, (3 reviews)
"I like the service and it’s really comfortable. And the people in their recession. Bety. Help. Take you guys. I Enjoy the State. I’m planning to Come Back. How old is go back to the hotel again!"
United States
Welinton
The price is RM108
RM108 total
13 Aug - 14 Aug
Hotel Moore 45
Egyptian cotton sheets, premium bedding, down duvets

12. Factory Lofts

Factory Lofts
4.0 star property
Laureles - Estadio
9.8 out of 10, Exceptional, (139 reviews)
"All the staff were absolutely great with a special thanks to Andres and Santiago! The cleaning was great and the location very convenient to everything and honestly a lot quieter than most of Calle 70.. Would definitely recommend and hope to visit soon"
United States
Firas Ghazi
The price is RM366
RM483 total
24 Aug - 25 Aug
Factory Lofts
Lobby

13. Haven, A Design Hotel

Haven, A Design Hotel
4.0 star property
El Poblado
8.8 out of 10, Excellent, (720 reviews)
"The entire staff from the doorman, reception, housekeeper, bartender, and cooks are all so very welcoming."
United States
robert
The price is RM371
RM371 total
17 Aug - 18 Aug
Haven, A Design Hotel
Living area

14. Urban Lofts Laureles 40

Urban Lofts Laureles 40
4.0 star property
Laureles
10.0 out of 10, Exceptional, (4 reviews)
"Great exprience. Great place. Great location."
United States
Victor
The price is RM223
RM289 total
13 Aug - 14 Aug
Urban Lofts Laureles 40
Front of property

15. Seissta Medellin

Seissta Medellin
4.0 star property
El Poblado
9.4 out of 10, Exceptional, (271 reviews)
"Very Clean and Friendly Staff."
United States
Paul
The price is RM429
RM429 total
25 Aug - 26 Aug
Seissta Medellin
Outdoor spa tub

16. Quadrato Studios

Quadrato Studios
3.0 star property
Laureles
9.4 out of 10, Exceptional, (108 reviews)
"Beautiful hotel great location great breakfast"
United States
gary
The price is RM204
RM204 total
18 Aug - 19 Aug
Quadrato Studios
Staircase

17. zenia

zenia
3.0 star property
Laureles
9.4 out of 10, Exceptional, (60 reviews)
"Room was perfect, if you’re staying for a long trip, I highly recommend getting the room with the washer. Super clean and amazing location."
United States
Kirman
The price is RM128
RM128 total
13 Aug - 14 Aug
zenia
In-room safe, blackout curtains, iron/ironing board (on request)

18. Origen Local Suites

Origen Local Suites
3.0 star property
Laureles
9.4 out of 10, Exceptional, (212 reviews)
"Great place.!"
United States
jeremy
The price is RM280
RM280 total
24 Aug - 25 Aug
Origen Local Suites
Premium bedding, in-room safe, desk, iron/ironing board

19. HOUSY Laureles

HOUSY Laureles
4.0 star property
Laureles
9.2 out of 10, Wonderful, (103 reviews)
"The staff was very friendly—Juliana, in particular, was very kind. There is a security company with a 24/7 guard in the building across the street."
United States
Moraima
The price is RM201
RM332 total
1 Sept - 2 Sept
HOUSY Laureles
Premium bedding, in-room safe, desk, laptop workspace

20. The Somos Flats Laureles

The Somos Flats Laureles
4.0 star property
Laureles
9.0 out of 10, Wonderful, (63 reviews)
"Great property and very accommodating host."
United States
Joseph
The price is RM226
RM226 total
24 Aug - 25 Aug
The Somos Flats Laureles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santa Cruz Hotel Reviews

The Click Clack Hotel Medellin

The Click Clack Hotel Medellin

10/10 Excellent
"Excelente ubicación, staff, amenidades, desayuno riquísimo."
Rey 7-night trip
Posted 1 hour ago
The Click Clack Hotel Medellin

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia.co.uk! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
  • Use the map to find apartments and other holiday homes in the Santa Cruz neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Cruz while they last

Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a holiday rental in Santa Cruz?

Yes, there are holiday rentals close to the most popular sights in Santa Cruz, or you can select a more secluded option if you're looking for a relaxing stay.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the wider area, you’ll find University of Antioquia and Arvi Park.

What’s a holiday rental in Santa Cruz like?

Holiday rentals are private properties where you can stay for a few weeks, or just a few days, in Santa Cruz. Holiday rentals offer extras like WiFi and washers and dryers so you'll feel right at home. If you're concerned about a clean environment, holiday rentals can offer a sense of safety away from public hotel lifts and lobbies bustling with people while still allowing you the enjoyment of travel. You'll also find more space in a holiday rental than in a standard hotel, which is another reason why a holiday rental is a popular option for families.