Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
26 Dec - 28 Dec
In two months
6 Feb - 8 Feb
In three months
6 Mar - 8 Mar
In four months
3 Apr - 5 Apr

Our top choices for Santa Cruz holiday rentals

Indoor pool, outdoor pool, pool loungers
York Medellin, Curio Collection by Hilton

York Medellin, Curio Collection by Hilton

York Medellin, Curio Collection by Hilton
4.0 star property
El Poblado
9.6 out of 10, Exceptional, (1417)
"Great place to stay !"
United States
Lendsey
The price is RM522
RM522 total
11 Jan - 12 Jan 2026
York Medellin, Curio Collection by Hilton
Lobby
Haven

Haven

Haven
4.0 star property
El Poblado
8.8 out of 10, Excellent, (637)
"Friendly staff, great rooftop bar and pool, very clean."
United States
Jason
The price is RM420
RM420 total
16 Dec - 17 Dec
Haven
Terrace/patio
Royal Living Poblado

Royal Living Poblado

Royal Living Poblado
4.0 star property
El Poblado
9.2 out of 10, Wonderful, (52)
"Comfortable and safe stay"
United States
Julian
Royal Living Poblado
Exterior
ecohotel zona 7

ecohotel zona 7

ecohotel zona 7
5.0 star property
Rionegro
7.6 out of 10, Good, (11)
"We had a really good experience. They were super helpful and friendly. "
Canada
Carolina
The price is RM154
RM682 total
14 Dec - 15 Dec
ecohotel zona 7
Living area
Wake Living

Wake Living

Wake Living
4.0 star property
El Poblado
8.8 out of 10, Excellent, (167)
"Great location best views"
United States
William
Wake Living
Minibar, individually decorated, individually furnished, free WiFi
Wasikuna cabañas rurales tipo glamping

Wasikuna cabañas rurales tipo glamping

Wasikuna cabañas rurales tipo glamping
3.0 star property
Guarne
10.0 out of 10, Exceptional, (4)
"Nice place "
United States
GERARDO
Wasikuna cabañas rurales tipo glamping
Living area
Skyline Ecoliving

Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.2 out of 10, Wonderful, (37)
"Great all around. Incredible views."
United States
Victor
Skyline Ecoliving
Fridge, microwave, stovetop, cookware/dishes/utensils
PORTANOVA SUITES by ADVENTU

PORTANOVA SUITES by ADVENTU

PORTANOVA SUITES by ADVENTU
3.0 star property
Rionegro
8.6 out of 10, Excellent, (41)
"Everything was perfect"
United States
Ancizar
PORTANOVA SUITES by ADVENTU
1 bedroom, free WiFi
Shabbat Hotel Boutique

Shabbat Hotel Boutique

Shabbat Hotel Boutique
2.0 star property
San Vicente
10.0 out of 10, Exceptional, (1)
The price is RM347
RM347 total
13 Dec - 14 Dec
Shabbat Hotel Boutique
Front of property
Gaia en Medellín

Gaia en Medellín

Gaia en Medellín
3.0 star property
La América
10.0 out of 10, Exceptional, (1)
"Muy buena atención del personal, mucha empatía ante un problema suscitado, muchas gracias!!!"
Spain
Mariano Jose
The price is RM136
RM136 total
13 Dec - 14 Dec
Gaia en Medellín
Outdoor spa tub
Metropolitan Living by HOUSY

Metropolitan Living by HOUSY

Metropolitan Living by HOUSY
4.0 star property
San Diego
9.4 out of 10, Exceptional, (22)
"Great location."
United States
Nekitta
The price is RM213
RM336 total
13 Dec - 14 Dec
Metropolitan Living by HOUSY
50-inch flat-screen TV with cable channels, TV
Apartment 301

Apartment 301

Apartment 301
3.0 star property
La Candelaria
9.8 out of 10, Exceptional, (6)
"Comfortable place"
United States
oscar
Apartment 301
Living area
APARTA HOTEL PROVENZA

APARTA HOTEL PROVENZA

APARTA HOTEL PROVENZA
2.0 star property
El Poblado
10.0 out of 10, Exceptional, (1)
"Everything was good, thanks."
United States
Melvin
The price is RM214
RM268 total
15 Dec - 16 Dec
APARTA HOTEL PROVENZA
Desk, laptop workspace, free WiFi
Cumbres Luxury Glamping

Cumbres Luxury Glamping

Cumbres Luxury Glamping
3.0 star property
Guarne
8.8 out of 10, Excellent, (3)
"Hot tub outside was an experience. Very clean "
United States
FRANK
The price is RM406
RM406 total
23 Dec - 24 Dec
Cumbres Luxury Glamping
Restaurant
Seissta Medellin

Seissta Medellin

Seissta Medellin
4.0 star property
El Poblado
9.2 out of 10, Wonderful, (207)
"Clean room and amazing staff"
United States
Collins
The price is RM518
RM518 total
18 Dec - 19 Dec
Seissta Medellin
Dining
Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites
3.5 star property
Rionegro
8.2 out of 10, Very good, (463)
"Good property. "
United States
Ruth Marcela
Travelers Rio Verde Living Suites
Pool
Sites Hotel

Sites Hotel

Sites Hotel
4.0 star property
El Poblado
9.2 out of 10, Wonderful, (1099)
"Breakfast had a few options and air conditioning was good , staff was pleasant and helpful "
United States
Hilda
The price is RM454
RM454 total
12 Jan - 13 Jan 2026
Sites Hotel
Staircase
zenia

zenia

zenia
3.0 star property
Laureles
9.4 out of 10, Exceptional, (37)
"Very close to everything you need."
United States
Gabriel Martinez
The price is RM107
RM107 total
18 Dec - 19 Dec
zenia
Front of property
Hotel Rioverde- 5 minutos de cercanía al aeropuerto

Hotel Rioverde- 5 minutos de cercanía al aeropuerto

Hotel Rioverde- 5 minutos de cercanía al aeropuerto
4.5 star property
Rionegro
7.6 out of 10, Good, (53)
"The room was too noisy, communication was poor, and the owner was not kind at all. "
United States
Mr Nicolas
Hotel Rioverde- 5 minutos de cercanía al aeropuerto
Blackout curtains, iron/ironing board, free WiFi, bed sheets
Borbon Suites

Borbon Suites

Borbon Suites
3.0 star property
El Poblado
The price is RM164
RM267 total
4 Jan - 5 Jan 2026
Borbon Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

V Grand Hotel, a member of Radisson Individuals

V Grand Hotel, a member of Radisson Individuals

10/10 Excellent
"Todo bien"
MARILUZ 2-night trip
Posted 16 hours ago
V Grand Hotel, a member of Radisson Individuals

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia.co.uk! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
  • Use the map to find apartments and other holiday homes in the Santa Cruz neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Cruz while they last

Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Can I find a holiday rental in Santa Cruz?

Yes, there are holiday rentals close to the most popular sights in Santa Cruz, or you can select a more secluded option if you're looking for a relaxing stay.

What are some of the best holiday rentals that Santa Cruz has to offer?

La Gracia Hotel & Spa: This holiday home rental outside of Santa Cruz offers a terrace, a garden and free WiFi to help you feel perfectly comfortable in your new surroundings.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the wider area, you’ll find Parque Fabricato Shopping Center and University of Antioquia.

What’s a holiday rental in Santa Cruz like?

Holiday rentals are private properties where you can stay for a few weeks, or just a few days, in Santa Cruz. Holiday rentals offer extras like WiFi and washers and dryers so you'll feel right at home. If you're concerned about a clean environment, holiday rentals can offer a sense of safety away from public hotel lifts and lobbies bustling with people while still allowing you the enjoyment of travel. You'll also find more space in a holiday rental than in a standard hotel, which is another reason why a holiday rental is a popular option for families.