Hotels in Medical Center District, San Antonio
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Our top choices for Medical Center District hotels
San Antonio Marriott Northwest Medical Center
San Antonio Marriott Northwest Medical CenterMedical Center District
8.6 out of 10, Excellent, (1007)
"Best hotel!"
Valeria
The price is RM378
RM449 total
includes taxes & fees
1 Jan - 2 Jan 2026
Fairfield Inn & Suites by Marriott San Antonio Medical Center
Fairfield Inn & Suites by Marriott San Antonio Medical CenterMedical Center District
9.0 out of 10, Wonderful, (1004)
"Everything was great, staff really kind ..."
traci
The price is RM338
RM395 total
includes taxes & fees
31 Dec - 1 Jan 2026
SpringHill Suites by Marriott San Antonio Medical Center/NW
SpringHill Suites by Marriott San Antonio Medical Center/NWMedical Center District
8.8 out of 10, Excellent, (1002)
"good staff. good stay"
Divya
The price is RM412
RM487 total
includes taxes & fees
23 Dec - 24 Dec
Drury Inn & Suites San Antonio Northwest Medical Center
Drury Inn & Suites San Antonio Northwest Medical CenterMedical Center District
9.2 out of 10, Wonderful, (1293)
"Great place to stay and visit "
Harry
The price is RM367
RM434 total
includes taxes & fees
4 Jan - 5 Jan 2026
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NWMedical Center District
8.6 out of 10, Excellent, (3132)
"Great place "
Amado
The price is RM362
RM428 total
includes taxes & fees
23 Dec - 24 Dec
Courtyard by Marriott Medical Center San Antonio
Courtyard by Marriott Medical Center San AntonioMedical Center District
8.8 out of 10, Excellent, (1003)
"Clean room, very close to medical center, and personnel at check in were very friendly."
Melinda
The price is RM343
RM405 total
includes taxes & fees
28 Dec - 29 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Medical Center District
Find the best Medical Center District areas for the activities you enjoy most.
Downtown San Antonio
Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.
Uptown
If you're spending some time in Uptown, San Antonio River and Marion Koogler McNay Art Museum are top sights worth seeing.
Far West Side
While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.
Stone Oak
Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista while you're in town.
Northwest Side
If you're spending some time in Northwest Side, Huebner Oaks and Convocation Center are top sights worth seeing.
Top Medical Center District Hotel Reviews
Drury Plaza Hotel San Antonio Riverwalk
10/10 Excellent
