A coastal landscape with clear turquoise waters, a long bridge, and a small island with buildings.

Highgate Independent Lower Florida Keys hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
23 Sept - 24 Sept
Tomorrow
24 Sept - 25 Sept
This weekend
25 Sept - 27 Sept
Next weekend
2 Oct - 4 Oct

Our top choices for Lower Florida Keys Highgate Independent

A room with a view of the beach and ocean, a bed with a white and blue blanket, and a small table with a potted plant.
A beach scene with two people relaxing under a white umbrella, a palm tree, and a clear blue sky.
A beachside hotel with rows of blue lounge chairs and white umbrellas, palm trees, and a clear blue sky.
A poolside area with lounge chairs and umbrellas, palm trees, and a view of the sea.

1. Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses
Old Town Key West
United States
Deaenna
RM652
RM1,032 total
includes taxes & fees
29 Sept - 30 Sept
Southernmost Beach Resort and Guesthouses
A hotel room with a bed, a sofa, a round table with a book, a window with a view, and a radiator.
A couple holding hands in a tropical setting with palm trees and greenery.
A modern cafe with a wooden counter, seating area, and shelves stocked with beverages.

2. Blue Flamingo Resort Key West

Blue Flamingo Resort Key West
New Town
United States
Esteban
RM481
RM771 total
includes taxes & fees
29 Sept - 30 Sept
Blue Flamingo Resort Key West
A large, white, two-story building with a balcony and a sign reading "The Marker Resort."
A tropical setting with palm trees and a building with a white facade and dark roof.
A covered outdoor area with a pool, palm trees, and lounge chairs.
A resort with a swimming pool, lounge chairs, umbrellas, and palm trees.

3. The Marker Key West Harbor Resort

The Marker Key West Harbor Resort
Key West Historic District
United States
Joelle
RM771
RM1,124 total
includes taxes & fees
29 Sept - 30 Sept
The Marker Key West Harbor Resort
A white picket fence, a sign for Duval Gardens Bed & Breakfast, and a palm tree.
A porch with wicker chairs and a table, white railings, and a window with a view of a palm tree.

4. Duval Gardens at Southernmost Beach Resort – Adults Only

Duval Gardens at Southernmost Beach Resort – Adults Only
Old Town Key West
United States
JoAnn
Duval Gardens at Southernmost Beach Resort – Adults Only
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Top Lower Florida Keys Hotel Reviews

Looe Key Reef Resort

Looe Key Reef Resort

10/10 Excellent
"Had a great time over the weekend . Great vibe!"
Michel 1-night trip
Posted 22 hours ago
Looe Key Reef Resort
Parmer's Resort

Parmer's Resort

10/10 Excellent
"Wonderful experience! We could walk out of our room to enjoy the water. Nice amenities too! Kayaks and more available, excellent breakfast every morning, way better than the standard breakfast. We would definitely stay there again."
Keith 5-night trip
Posted 3 days ago
Parmer's Resort
Sugarloaf Key Hotel at KOA Resort

Sugarloaf Key Hotel at KOA Resort

10/10 Excellent
"Extraordinarily clean and well maintained. We stayed in the hotel which was well thought out"
Patrick 4-night trip
Posted 4 days ago
Sugarloaf Key Hotel at KOA Resort

Explore a world of travel with Expedia